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Dermatologists are essential in helping transgender and gender diverse patients with skin and hair issues related to gender affirmation and hormone therapy.

A 13-year-old with 46 XY DSD had ambiguous genitalia due to incomplete masculinization.

Mouse genital development depends on male or female hormones for specific features.

Blocking a specific enzyme in male rat fetuses leads to the development of nipples and feminized genitalia.

DSDs are birth conditions causing unusual sex development, managed with personalized care and sometimes surgery, but still lack a standard treatment approach.

Higher fluoride levels may delay puberty in boys.

5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.

Late diagnosis of congenital adrenal hyperplasia can greatly affect physical development, gender identity, and sexual health.

A boy with a new NR5A1 gene mutation has a sex development disorder without affecting his adrenal glands.

A Saudi individual initially identified as a girl had a genetic disorder affecting gender development.

Gene mutations can cause problems in male genital development.

The patient had complex urinary tract issues and ambiguous genitalia, with physical features suggesting a hormonal imbalance.

Hormones, especially testosterone and DHT, are key for penis development and function, and testosterone therapy may help with erectile dysfunction in those with low levels.

Finasteride exposure affects gene expression and anogenital distance in male rat fetuses.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

A hair strand caused a rare case of limb strangulation in a teenage girl with autism, and the condition is not always linked to child abuse.

The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

Finasteride exposure in pregnancy causes genital abnormalities in male rats.

Smad-4 and Smad-7 are key in hair follicle development, with other Smads being less important.

Finasteride effectively treats BPH, but needs more trials to understand potential.

Diagnosing sex development disorders requires combining medical history, physical exams, imaging, lab tests, and genetic data.

A 10-year-old boy with abnormal genital development had surgery and tests to find the cause and plan treatment.

Finasteride negatively affects fish reproduction and gonadal development.

Continuous research and innovative strategies are essential for sustainable development.

Sex hormones affect reproduction, sexual development, and oral health, and it's important for dental practitioners to understand their effects and interactions.

Exposure to finasteride in the womb caused lasting reproductive issues in male rats.

Not enough vitamin B6 in pregnant rats' diets caused poor development and health in their babies.

The nucleus is key in controlling skin growth and repair by coordinating signals, gene regulators, and epigenetic changes.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.