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    Glossary Gene Clusters

    groups of related genes located close together on a chromosome

    Gene clusters, also known as gene groupings or genetic clusters, are groups of two or more genes located close to each other on a chromosome that are often functionally related. These genes are typically co-regulated and may be involved in similar biological processes, such as the production of enzymes in a metabolic pathway or the development of specific tissues. For example, in the context of hair biology, a gene cluster might include several genes that collectively influence hair growth and pigmentation.

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    1. A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3 Genomics · 2004 · 34 citations
    2. The organization of the keratin I and II gene clusters in placental mammals and marsupials show a striking similarity European Journal of Cell Biology · 2005 · 18 citations
    3. Overexpression of Hoxc13 in differentiating keratinocytes results in downregulation of a novel hair keratin gene cluster and alopecia Development · 2001 · 114 citations
    4. A gene for pachyonychia congenita is closely linked to the keratin gene cluster on 17q12-q21. Journal of Medical Genetics · 1994 · 61 citations
    5. Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21 2001 · 98 citations
    6. A gene for monilethrix is closely linked to the type II keratin gene cluster at 12q13 Human Molecular Genetics · 1995 · 54 citations
    7. Human Trichohyalin Gene Is Clustered with the Genes for Other Epidermal Structural Proteins and Calcium-Binding Proteins at Chromosomal Locus 1q21 Journal of Investigative Dermatology · 1993 · 37 citations
    8. Mapping of monilethrix to the type II keratin gene cluster at chromosome 12q13 in three new families, including one with variable expressivity British Journal of Dermatology · 1997 · 21 citations
    9. Human Trichohyalin Gene Is Clustered with the Genes for Other Epidermal Structural Proteins and Calcium-Binding Proteins at Chromosomal Locus 1q21 1993
    10. Comparative genomics of the keratin-associated protein (KAP) gene clusters in human, chimpanzee, and baboon Mammalian genome · 2004 · 8 citations
    11. Terrestrial vertebrates have two keratin gene clusters; striking differences in teleost fish European Journal of Cell Biology · 2005 · 47 citations
    12. Multiomics global landscape of stemness-related gene clusters in adipose-derived mesenchymal stem cells Stem Cell Research & Therapy · 2020 · 13 citations
    13. The Human Type II Keratin Gene Cluster on Chromosome 12q13.13: Final Count or Hidden Secrets? 2005 · 9 citations
    14. Linkage of Monilethrix to the Trichocyte and Epithelial Keratin Gene Cluster on 12q11-q13 Journal of Investigative Dermatology · 1996 · 43 citations
    15. Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice MDPI (MDPI AG) · 2026
    16. Hairless-knockout piglets generated using the clustered regularly interspaced short palindromic repeat/CRISPR-associated-9 exhibit abnormalities in the skin and thymus 2019 · 3 citations
    17. Human Hair Keratin-Associated Proteins 2005 · 71 citations
    18. Mouse Hair Cycle Expression Dynamics Modeled as Coupled Mesenchymal and Epithelial Oscillators PLOS Computational Biology · 2014 · 12 citations
    19. [Genetic and biochemical aspects of keratin synthesis by hair follicles]. PubMed · 2007 · 10 citations
    20. Computational derivation of a molecular framework for hair follicle biology from disease genes Scientific Reports · 2017 · 4 citations
    21. 644 Tumor cell adhesion as a risk factor for SLN metastasis and predictor of disease recurrence in primary cutaneous melanoma Journal of Investigative Dermatology · 2016
    22. Disturbance of Immune Microenvironment in Androgenetic Alopecia through Spatial Transcriptomics International Journal of Molecular Sciences · 2024
    23. 1379 Cell of origin contributes to the melanoma diversity Journal of Investigative Dermatology · 2018
    24. 498 A Multi-Omics Approach to create a Human Hair Atlas for healthy and AGA models Journal of Investigative Dermatology · 2024
    25. Single–Follicular-Unit Hair Transplantation to Correct Cleft Lip Moustache Alopecia The Cleft Palate Craniofacial Journal · 2001 · 11 citations
    26. Single–Follicular-Unit Hair Transplantation to Correct Cleft Lip Moustache Alopecia The Cleft Palate Craniofacial Journal · 2001 · 6 citations
    27. 267 Deep phenotyping of patients with xeroderma pigmentosum and trichothiodystrophy Journal of Investigative Dermatology · 2017
    28. Mammalian-specific ectodermal enhancers control the expression of <i>Hoxc</i> genes in developing nails and hair follicles Proceedings of the National Academy of Sciences · 2020 · 25 citations
    29. Skin regional specification and higher-order <i>HoxC</i> regulation Science Advances · 2025 · 3 citations
    30. Hox in the Niche Controls Hairy-geneity Cell Stem Cell · 2018 · 4 citations