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This study found that both declining levels of the neurosteroid THP and increasing levels of estradiol before puberty trigger maximal expression of α4βδ GABAA receptors in the CA1 hippocampus of female mice.

This study found that finasteride increased fetal arousal activity in late gestation sheep by suppressing pregnane steroid synthesis, suggesting reduced GABAA receptor-mediated inhibition.

This study reported that in rat retinas under high pressure, allopregnanolone synthesis increased and helped reduce pressure-induced damage through GABAA receptors, suggesting potential therapeutic use in glaucoma.

This study found enhanced remyelination in the corpus callosum of late pregnant rats compared to virgin and postpartum rats, suggesting a pregnancy-associated promyelinating effect mediated, in part, by the GABA A receptor system.

This study found that neurosteroids and benzodiazepines decrease network excitability in neuronal cultures, with specific long-term depressive effects on inhibitory neurons.

This study found that inhaling toluene reduces core temperature in mice, with GABA receptors and neurosteroids involved at 4000 ppm, but different mechanisms contributing at 6000 ppm.

This study found that in rodent models, the ability of D1 dopamine receptor activation to impair sensory gating is facilitated by 5α-reductase type 1, which produces allopregnanolone.

In this review, researchers examined the complex interaction of hormones, genes, and reactive oxygen species in hirsutism and PCOS, highlighting prolactin's role in modulating hormone levels linked to hair growth disorders.

This editorial discusses the hormonal basis of catamenial epilepsy, particularly focusing on the roles of progesterone and neurosteroids, and presents no new research findings.

This editorial discusses the implications of neuroimaging for the treatment of epilepsy and reports no new clinical results; the author emphasizes its potential impact on therapeutic strategies.

This study found that neurosteroids can reorganize GABA A receptors in mice, mimicking ovarian cycle changes, with the process being mediated by neurosteroid levels rather than direct hormone receptor activation.

This study found that the antidepressant-like effect of fluoxetine in mice was only observed when a 5-minute pretest session was conducted, and this effect was blocked by the TSPO antagonist PK11195.

This study found that thalamic GABAA receptor α4 subunit levels increased after prolonged ethanol exposure and were regulated by phosphorylation and neuroactive steroids following acute high-dose ethanol administration.

This study found that subchronic finasteride treatment in male rats altered neuroactive steroid levels and steroid receptor expression in the brain, with some changes persisting after drug withdrawal.

The study found that ondansetron decreased alcohol consumption only in adult rats that experienced altered neuroactive steroid levels from early post-natal finasteride exposure, suggesting increased 5HT3 receptor sensitivity in these rats.

This review discusses recent findings on cellular antioxidant responses to oxidative stress and their implications for treating various human diseases but reports no new clinical results.

This study found that neuroactive steroids, through their interaction with the sigma1 receptor, influence the acquisition of cocaine's rewarding effects in mice, suggesting a role in drug addiction vulnerability.

This article reviews the potential clinical use of anabolic steroids in treating muscle loss from chronic diseases and aging and highlights both the benefits and risks of these substances in sports.

In this study with a mouse model of catamenial epilepsy, ferulic acid may effectively reduce seizure susceptibility and depression-like behavior by influencing hormone levels and neurotransmitter activity.

This study suggests that the 5α-reductase inhibitor finasteride modulates sensorimotor gating in rats by affecting D1 and D3 receptors, but not D2 receptors, with varying effects based on genetic strain.

This study found that augmenting or reducing allopregnanolone activity in the BNST affected contextual fear expression in rats, suggesting sex differences in anxiety may be linked to neuroactive steroid regulation.

In this animal study, the methanolic extract of Crataeva nurvala leaves was found to possess sedative and anxiolytic properties, potentially linked to GABAergic activity and certain neuroactive compounds.

Neurosteroids in the brain can increase or decrease seizure risk in mice.

This study found that diazepam had an exaggerated effect on GABA-related inhibitory tone in diabetic neuropathic mice compared to normal mice, potentially due to mitochondrial dysfunction affecting neurosteroid synthesis.

Olanzapine reduces stress-related anxiety in rats when given acutely.

This study found that in Withdrawal Seizure-Prone mice, ethanol withdrawal decreased the sensitivity of GABA A receptors to GABAergic neurosteroids in certain areas of the brain.

AC-5216 reduces anxiety in mice through neurosteroids affecting GABAA receptors.

This study suggests that progesterone has both THP/GABAA-dependent and independent anticonvulsive effects in a hippocampal-kindled mouse model.

This study suggests that post-finasteride syndrome and post-SSRI sexual dysfunction share potential etiopathogenetic mechanisms involving brain modulators, neurotransmitters, and gut microbiota, although more research is needed to understand these conditions fully.

This review discusses the role of microglia in mediating prenatal androgen effects on the female brain, potentially contributing to PCOS development and neuroendocrine dysfunctions, but reports no new results.