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This study suggests that progesterone may have a complex role in absence epilepsy, facilitating seizures through conversion to allopregnanolone, but potentially reducing them during pregnancy.

Isolation stress in rats reduces brain enzyme levels, affecting dopamine function.

This study suggests that the anticonvulsant effects of deoxycorticosterone in young rats may be mediated by its metabolites and interactions with multiple receptors, including mineralocorticoid and progesterone receptors.

This review discusses the effects of neuroactive testosterone metabolites on CNS functions and suggests their potential as therapeutic options for neurological disorders, but reports no new clinical results.

This study found that finasteride treatment in men with benign prostate hyperplasia significantly altered steroid hormone profiles and may contribute to depressive symptoms by affecting neuroactive steroid levels.

This study found that chronic exposure to and withdrawal of progesterone influenced the expression and function of GABA A receptors in rat hippocampal neurons through its metabolite 3α,5α‐THPROG.

This article discusses the functions of the enzyme 17beta-HSD10, including its role in steroid metabolism and potential links to Alzheimer's disease, but reports no new experimental findings.

This article reviews the uses, mechanisms, and side effects of valproate in treating bipolar disorder, noting its first-line status for several manic conditions but also highlighting serious risks such as fetal abnormalities.

This study found that blocking GABA(A) receptors in cat dorsal horn neurons increased evoked activity and background discharge, highlighting differences in inhibitory control systems compared to glycine receptors.

This study found that chronic ethanol exposure and withdrawal alter the expression and function of GABA-A receptors in rat hippocampal and cerebellar neurons, suggesting different roles for these receptors in controlling tonic inhibition.

This study suggests that in late pregnancy, allopregnanolone induces opioid inhibition of oxytocin secretion in response to immune challenge, potentially minimizing the risk of preterm labor in rats.

This review summarizes the role of neurosteroids in seizure disorders and highlights the potential of neurosteroid replacement therapy in epilepsy but presents no new clinical findings.

This study demonstrated that the glycolytic inhibitor 2-deoxy-D-glucose enhances antiseizure effects by potentiating extrasynaptic tonic GABAergic inhibition through neurosteroidogenesis in hippocampal slices.

Progesterone reduces anxiety without needing progesterone receptors.

A neurosteroid can reduce caffeine-induced anxiety in rats.

This study suggests that ovarian cycle-related progesterone and neurosteroids regulate α2-subunit expression of GABA-A receptors in the hippocampus through a pathway independent of progesterone receptors, potentially affecting brain conditions linked to the menstrual cycle.

This study concluded that 16β-methyl-17α-benzoyloxypregnen-4-en-3,20-dione may be a promising treatment for androgen-dependent diseases and epilepsy due to its antioxidant effects and impact on GABAergic and serotonergic metabolism in rats.

This study suggests that in an ex vivo rat glaucoma model, TSPO activation is involved in Allopregnanolone synthesis and may help prevent retinal damage, with TSPO agonists as potential therapeutic agents.

This study found that a topical hedgehog agonist can stimulate hair growth by promoting the transition from the resting to growth phase of the hair cycle in adult mouse skin.

This review discusses manipulating the stem cell niche as a strategy in regenerative medicine to repair damaged tissues, highlighting the potential benefits and challenges but reporting no new results.

This study found that photoexposure significantly increased the gene expression of altered elastin, MMP12, and LOX, as well as the protein expression of tropoelastin and fibrillin-1, in skin models.

This study found that neurotrophin-4 regulates Cav3.2 T-current expression in D-hair neurons via TrkB receptor activation, highlighting its role in mechanosensitive function.

This study found that neuroactive steroids like DHEA and pregnenolone influence cocaine-induced appetence in mice through their interaction with the ς₁ receptor, suggesting a role in individual vulnerability to addiction.

This study found that progesterone pretreatment in rats potentiated the effect of ethanol on mesocortical dopamine levels, suggesting an influence of neuroactive steroids on ethanol's action.

This study found that neonatal finasteride treatment in male rats altered hippocampal GABAA receptor subunit expression and led to increased anxiety-like behavior in response to progesterone in adulthood.

This study found that combining platelet-rich plasma with adipose-derived mesenchymal stem cells significantly improved diabetic wound healing in rats by enhancing angiogenesis and modulating the Notch signaling pathway.

This study suggests that the regulation of GABA‐A δ subunit expression by ovarian progesterone-derived neurosteroids may influence seizure susceptibility in catamenial epilepsy.

This study found that the estrous cycle influences the effect of the δ-GABAAR agonist THIP in reducing binge drinking behavior in female mice, with receptor expression elevated during diestrus.

This study found that testosterone increased seizure severity in mice and rats, with its neurosteroid metabolites playing a role in modulating seizure susceptibility.

Neurosteroids may help prevent seizures in epilepsy.