94 citations
,
January 2000 in “The Journal of Clinical Endocrinology and Metabolism” This study found that spironolactone, flutamide, and finasteride are similarly effective in reducing hair diameter and Ferriman-Gallwey scores in women with hirsutism over a 6-month treatment period.
93 citations
,
January 1996 in “Clinical Pharmacokinectics” Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.
91 citations
,
April 2017 in “Diabetes & Metabolic Syndrome: Clinical Research and Reviews” This review discusses the role of dietary habits and lifestyle modifications in managing polycystic ovary syndrome and reports no clinical results; the authors emphasize the need for tailored diet therapy in affected women.
90 citations
,
January 2021 in “Clinical Endocrinology” This review discusses the impact of weight gain and obesity on the development of polycystic ovary syndrome and explores lifestyle strategies to manage the condition, without reporting new clinical results.
90 citations
,
February 2013 in “The Journal of Clinical Endocrinology and Metabolism” This study found that women with polycystic ovary syndrome have higher global adiposity and increased visceral fat, particularly in the ip and mesenteric depots, compared to women without androgen excess.
89 citations
,
November 2014 in “Medical Clinics of North America” This article reviews management strategies for PCOS and reports no new clinical results; the authors highlight oral contraceptives, lifestyle modifications, and metformin as key interventions.
88 citations
,
April 2017 in “Journal of Pediatric and Adolescent Gynecology” This review discusses the pathophysiology, diagnosis, and treatment of congenital adrenal hyperplasia, but reports no new research results.
88 citations
,
June 2016 in “Human Reproduction Update” This review discusses developments in oral contraceptives, highlighting improved individualization, reduced side effects, and enhanced suitability for various women's health needs, but it reports no new clinical results.
88 citations
,
May 2012 in “Human Reproduction Update” This review discusses WHO group 2 anovulation, highlighting polycystic ovary syndrome as a common cause of infertility and noting current treatment options without presenting new clinical results.
88 citations
,
February 2010 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” This study reported that vitiligo patients in Turkey had a high prevalence of associated autoimmune diseases and auditory problems, suggesting vitiligo may be part of a systemic autoimmune process.
87 citations
,
July 2018 in “Nursing Clinics of North America” This review discusses the diagnostic criteria and treatment options for polycystic ovary syndrome focusing on metabolic subtypes and reports no clinical results.
86 citations
,
July 1993 in “Drugs” Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.
85 citations
,
May 2019 in “Journal of neuroendocrinology” This review examines the neuroendocrine mechanisms underlying seasonal changes in mammals and highlights areas needing further research, reporting no new experimental results.
85 citations
,
June 2008 in “Annals of the New York Academy of Sciences” This article proposes a hypothesis that hyperandrogenemia is the final common pathway for developing adolescent PCOS and emphasizes the importance of reducing androgen levels to mitigate risks of metabolic syndrome, diabetes, and infertility in adulthood.
84 citations
,
November 2003 in “European journal of endocrinology” This study found that women with androgenic alopecia had a higher prevalence of polycystic ovarian morphology and higher androgen levels compared to controls, suggesting a strong association with PCO.
81 citations
,
March 2009 in “Seminars in Cutaneous Medicine and Surgery” This review discusses the classifications, diagnostic methods, and treatment strategies for female pattern hair loss, but reports no clinical results.
research Acne
81 citations
,
January 2002 in “American journal of clinical dermatology” Hormonal treatments can help with acne, especially in women, by lowering androgen levels or blocking their effects.
80 citations
,
March 2004 in “Neuropediatrics” This article presents an update on a family with Coats' plus disorder, documenting additional symptoms and two new similar cases, and reviews literature suggesting a link to dyskeratosis congenita for potential molecular insights.
78 citations
,
May 1989 in “The Journal of Clinical Endocrinology & Metabolism” This study found that in hirsute women, daily treatment with 200 mg spironolactone significantly reduced hair growth rates and hair shaft diameters on various body areas over 12 months.
77 citations
,
June 2015 in “Nature Reviews Urology” This article reviews the effects of various medications on male fertility, noting that while commonly used drugs can mostly have reversible impacts, conclusive human evidence remains limited.
76 citations
,
November 2009 in “Medical Clinics of North America” This article reviews the hormonal and medication-related factors associated with acne development but does not present new research findings.
76 citations
,
January 2007 in “American Journal of Clinical Dermatology” This review discusses the dermatologic features of PCOS as potential early indicators of the syndrome and notes that treatment of these conditions may enhance quality of life and psychological well-being, but it reports no new clinical results.
76 citations
,
December 1997 in “Fertility and Sterility” This study found that spironolactone was significantly more effective than finasteride in reducing hirsutism scores over 9 months, despite more side effects occurring in the spironolactone group.
75 citations
,
October 1999 in “European journal of endocrinology” This study found that both finasteride and flutamide effectively reduce hirsutism in women with polycystic ovary syndrome or idiopathic hirsutism, but flutamide was more effective.
75 citations
,
March 1999 in “Fertility and sterility” This study concluded that finasteride, cyproterone acetate, and flutamide were similarly effective at reducing hirsutism in women, though they acted through different mechanisms.
75 citations
,
November 1996 in “Fertility and Sterility” This study found that finasteride effectively reduced hirsutism in women during 12 months of treatment, with some effects persisting in the majority after stopping the medication.
74 citations
,
July 2010 in “The Journal of Clinical Endocrinology & Metabolism” This study found that gonadal dysfunction is very common in premenopausal women with acromegaly and may be caused by hyperprolactinemia, GH/IGF-I excess, or tumor effects.
73 citations
,
June 2008 in “The Journal of Clinical Endocrinology and Metabolism” This study provides further evidence for a genetic basis of PCOS, showing that polycystic ovarian morphology is a marker of inherited biochemical features in families with PCOS.
73 citations
,
January 1994 in “European Urology” This study found that finasteride significantly reduced serum dihydrotestosterone levels, confirming its efficacy as a 5a-reductase inhibitor, while Permixon showed no effect in healthy male volunteers.
72 citations
,
October 1998 in “Baillière's clinical endocrinology and metabolism” This article discusses the potential effects of exogenous testosterone, highlighting that its impact on prostate cancer progression, cardiovascular health, and behavior remains uncertain and needs further investigation.