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    Glossary Frizz

    hair that appears dry, unruly, and lacks smoothness

    Frizz, also known as frizziness or frizzy hair, refers to hair that appears dry, unruly, and lacks smoothness, often resulting in individual strands standing up or curling independently. This condition is typically caused by a lack of moisture in the hair shaft, leading to the cuticle layer lifting and allowing humidity to penetrate, which disrupts the hair's natural structure. Factors such as hair damage, humidity, and the hair's natural texture can all contribute to frizz.

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    1. Frizzled Receptors in Development and Disease 2016 · 114 citations
    2. When whorls collide: the development of hair patterns in frizzled 6 mutant mice Development · 2010 · 55 citations
    3. The mouse frizzy (<i>fr</i>) and rat ‘hairless’ (<i>fr</i><sup><i>CR</i></sup>) mutations are natural variants of protease serine S1 family member 8 (<i>Prss8</i>) Experimental Dermatology · 2010 · 28 citations
    4. <i>De Novo</i> design of a potent Wnt Surrogate specific for the frizzled7 subtype members bioRxiv (Cold Spring Harbor Laboratory) · 2025
    5. Peptide CyRL-QN15 accelerates hair regeneration in diabetic mice through binding to the Frizzled-7 receptor 动物学研究 · 2024
    6. [Frizzy hair pathology]. PubMed · 2011
    7. Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle Stem Cells International · 2017 · 8 citations
    8. Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles PeerJ · 2019 · 7 citations
    9. Follistatin and secreted frizzled-related protein 1, OVO homolog-like 1-regulated genes, are important for hair follicle neogenesis Experimental Dermatology · 2015 · 4 citations
    10. Secreted Frizzled‐Related Protein 2 ( SFRP2 ) Induces Follistatin‐Like 1 ( FSTL1 ) to Regulate Dihydrotestosterone ( DHT )‐Induced Dermal Papilla Cell Mitochondrial Dysfunction and Senescence Aging Cell · 2026
    11. Peer Review #2 of "Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles (v0.1)" 2019
    12. Peer Review #1 of "Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles (v0.1)" 2019
    13. The Chicken Frizzle Feather Is Due to an α-Keratin (KRT75) Mutation That Causes a Defective Rachis PLoS Genetics · 2012 · 99 citations
    14. Immunohistopathological analysis of frizzled-4-positive immature melanocytes from hair follicles of patients with Rhododenol-induced leukoderma Journal of dermatological science · 2015 · 8 citations
    15. The Anti-Flyaway/Frizz Effect by Inducing the α-Helical Structure Transition of Hair Cosmetics · 2024
    16. Normoglycemia and type 2 diabetes: exploring secreted frizzled-4, insulin resistance, and waist-height ratio Journal of the Pakistan Medical Association · 2024 · 2 citations
    17. Influence of Lipid Contents in Human Hair on the Hair Volume and Hair Frizzing Phenomena Journal of the Society of Cosmetic Scientists of Korea · 2020 · 1 citations
    18. Characterization and isolation of stem cell-enriched human hair follicle bulge cells 2005 · 550 citations
    19. Planar Cell Polarity Cadherin Celsr1 Regulates Skin Hair Patterning in the Mouse Journal of Investigative Dermatology · 2009 · 92 citations
    20. Order from disorder: Self-organization in mammalian hair patterning Proceedings of the National Academy of Sciences · 2006 · 91 citations
    21. The shampoo pH can affect the hair: Myth or Reality? International journal of trichology · 2014 · 51 citations
    22. Responses of hair follicle–associated structures to loss of planar cell polarity signaling Proceedings of the National Academy of Sciences of the United States of America · 2013 · 29 citations
    23. Partial interchangeability of <i>Fz3</i> and <i>Fz6</i> in tissue polarity signaling for epithelial orientation and axon growth and guidance Development · 2014 · 28 citations
    24. Functional redundancy of <i>Frizzled 3</i> and <i>Frizzled 6</i> in planar cell polarity control of mouse hair follicles Development · 2018 · 24 citations
    25. Baicalin increases hair follicle development by increasing canonical Wnt/β‑catenin signaling and activating dermal papillar cells in mice International Journal of Molecular Medicine · 2018 · 23 citations
    26. Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development Development · 2022 · 7 citations
    27. Collagen XVIII regulates basement membrane integrity : specific effects of its isoforms on the choroid plexus, kidney and hair follicle 2011 · 7 citations
    28. Comparative study of instrumental measurement and sensory evaluation methods for the repairing effect of mildly damaged hair bundles Skin Research and Technology · 2023 · 3 citations
    29. Development and sensory analysis of shampoo for curly hair Acervo Digital da Universidade Estadual Paulista (Universidade Estadual Paulista) · 2013 · 2 citations
    30. Magnetic coiffure: Engineering of human hair surfaces with polyelectrolyte-stabilised magnetite nanoparticles Chemical engineering journal advances · 2022 · 1 citations