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    Glossary Folliculin

    protein regulating cell growth and energy metabolism

    Folliculin, also known as FLCN, is a protein encoded by the FLCN gene. It plays a crucial role in regulating cell growth and energy metabolism. Mutations in the FLCN gene are associated with Birt-Hogg-Dubé syndrome, a condition that can lead to hair follicle tumors, lung cysts, and an increased risk of kidney cancer.

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    1. Folliculin encoded by the <i>BHD</i> gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling Proceedings of the National Academy of Sciences · 2006 · 475 citations
    2. Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion PloS one · 2012 · 72 citations
    3. Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis 2012 · 47 citations
    4. Folliculin Deficient Renal Cancer Cells Show Higher Radiosensitivity through Autophagic Cell Death 2014 · 4 citations
    5. Folliculin: A surprising molecular brake in the human hair follicle Journal of Investigative Dermatology · 2026
    6. Folliculitis decalvans including tufted folliculitis: clinical, histological and therapeutic findings British Journal of Dermatology · 1999 · 226 citations
    7. Action of isotretinoin in acne rosacea and gram-negative folliculitis Journal of The American Academy of Dermatology · 1982 · 175 citations
    8. Follicular and epidermal alterations in patients treated with ZD1839 (Iressa), an inhibitor of the epidermal growth factor receptor 2002 · 169 citations
    9. Folliculitis decalvans Dermatologic Therapy · 2008 · 112 citations
    10. Rapidly progressing mycosis fungoides presenting as follicular mucinosis Journal of the American Academy of Dermatology · 2000 · 76 citations
    11. Folliculitis decalvans: a multicentre review of 82 patients Journal of the European Academy of Dermatology and Venereology · 2015 · 68 citations
    12. Folliculitis American journal of clinical dermatology · 2004 · 64 citations
    13. Follicular mucinosis: A detailed morphologic and immunopathologic study Journal of the American Academy of Dermatology · 1984 · 51 citations
    14. Folliculitis Keloidalis Nuchae and Pseudofolliculitis Barbae Dermatologic clinics · 2014 · 49 citations
    15. Retrospective Review of Folliculitis Decalvans in 23 Patients with Course and Treatment Analysis of Long-standing Cases Journal of Cutaneous Medicine and Surgery · 2015 · 43 citations
    16. Folliculitis decalvans: Effectiveness of therapies and prognostic factors in a multicenter series of 60 patients with long-term follow-up Journal of The American Academy of Dermatology · 2018 · 41 citations
    17. Updates in therapeutics for folliculitis decalvans: A systematic review with evidence-based analysis Journal of the American Academy of Dermatology · 2018 · 40 citations
    18. Simultaneous occurrence of folliculitis decalvans capillitii in identical twins British Journal of Dermatology · 2000 · 39 citations
    19. Oral isotretinoin as the most effective treatment in folliculitis decalvans: a retrospective comparison of different treatment regimens in 28 patients Journal of the European Academy of Dermatology and Venereology · 2015 · 37 citations
    20. ‘Follicular Swiss cheese’ pattern - another histopathologic clue to alopecia areata Journal of Cutaneous Pathology · 2010 · 35 citations
    21. Keratosis Follicularis Spinulosa Decalvans Associated with Acne Keloidalis Nuchae and Tufted Hair Folliculitis American Journal of Clinical Dermatology · 2008 · 35 citations
    22. Effective treatment of folliculitis decalvans using selected antimicrobial agents International journal of trichology · 2010 · 33 citations
    23. Immunofluorescent findings and clinical overlap in two cases of follicular lichen planus Journal of the American Academy of Dermatology · 1982 · 32 citations
    24. Follicular and Scarring Disorders in Skin of Color: Presentation and Management American Journal of Clinical Dermatology · 2014 · 30 citations
    25. Follicular streamers (stelae) in scarring and non-scarring alopecia Journal of Cutaneous Pathology · 2008 · 29 citations
    26. Wolf's isotopic response: Trichophyton rubrum folliculitis appearing on a herpes zoster scar International Journal of Dermatology · 2000 · 28 citations
    27. Malassezia (Pityrosporon) Folliculitis Occurring During Pregnancy International Journal of Dermatology · 1986 · 28 citations
    28. Long-term remission of folliculitis decalvans after treatment with the long-pulsed Nd:YAG laser Journal of dermatological treatment · 2013 · 27 citations
    29. Photodynamic therapy for the treatment of folliculitis decalvans Photodermatology Photoimmunology & Photomedicine · 2012 · 25 citations
    30. Folliculitis decalvans associated with erlotinib Clinical and Experimental Dermatology · 2010 · 25 citations