research Do we need hair follicle stem cells and hair follicle neogenesis to cure common hair loss disorders?
This document includes a brief professional profile of Dr. Ralf Paus but presents no research findings or study results.
Search
for
Did you mean Hair Follicle Loss?
Sort by
Research
30 / 1000+ results 
research Hair Follicle Classification and Hair Loss Severity Estimation Using Mask R-CNN
This study reported that a new deep learning algorithm using Mask R-CNN improved hair follicle classification accuracy by 4 to 15%, suggesting potential clinical application for enhanced hair loss diagnosis.
research Controlling Hair Loss by Regulating Apoptosis in Hair Follicles: A Comprehensive Overview
This review highlights the importance of apoptosis in the hair cycle, particularly its role in hair follicle regression and loss, suggesting that understanding its mechanisms can aid in developing treatments to reduce hair loss and promote hair growth.
research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development
This review discusses the advancements in intraoperative stem cell therapies and highlights their potential to improve hair regrowth, but it reports no new clinical results.
research Stem cells from human hair follicles: first mechanical isolation for immediate autologous clinical use in androgenetic alopecia and hair loss
This study reported that using human follicle stem cells isolated from hair bulge areas increased hair density by about 29% over baseline in patients with androgenetic alopecia, with significant improvements observed 23 weeks after the last treatment.
research Loss of Vascular Endothelial Growth Factor in Human Alopecia Hair Follicles
Hair follicles in people with alopecia have lower levels of a key blood vessel growth protein.
research Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
In this study, severe hair loss occurred in PKC epsilon transgenic mice treated with DFMO during skin tumor prevention, highlighting a link between polyamine biosynthesis, hair follicle maintenance, and metastasis suppression.
research Pattern hair loss: Assessment of microinflammation in miniaturized and terminal hair follicles through horizontal histologic sections
This commentary reviews the evidence for microinflammation's role in pattern hair loss and suggests that further studies with age- and sex-matched controls are needed to substantiate the findings.
research Characterization of Hair Follicles in Hirosaki Hairless Rats with Deletion of Basic Hair Keratin Genes. Enlarged Medulla, Loss of Cuticle and Long Catagen
This study in hairless rats suggests that the deletion of specific hair keratin genes contributes to hypotrichosis and highlights the strain's potential as a model for hair follicle research.
research From a stem-cell–centered to a niche-centered view: the core role of collagen networks in hair loss and hair follicle miniaturization
In this study, researchers suggest that hair follicle miniaturization in conditions like androgenetic alopecia may result from impaired conversion of quiescent stem cells to progenitor cells, influenced by the follicular niche, its collagen network, and various mechanical constraints.
research Hair Loss Treatment Uses Stem Cells to Generate Healthy New Follicles
This article presents Stemson Therapeutics' development of a stem cell-based approach to generate new hair follicles for treating hair loss, which remains in preclinical stages without tested human results.
research Hair loss improvement effect of Chrysanthemum zawadskii, peppermint and Glycyrrhiza glabra herbal mixture in human follicle dermal papilla cell and C57BL/6 mice
This study suggests that a mixture of Chrysanthemum zawadskii, peppermint, and Glycyrrhiza glabra promotes hair growth and reduces hair loss markers in testosterone-treated cells and mice.
research HAIR LOSS ASSOCIATED WITH ESCITALOPRAM: DO SSRIs AFFECT MELATONIN AT THE HAIR FOLLICLE?
The antidepressant escitalopram likely caused hair loss in a patient.
research 905 Dysfunction of hair follicle mesenchymal progenitors is associated with age-related hair loss
This study found that the dysfunction of hair follicle dermal stem cells with age contributes to hair follicle aging and hair loss in mice.
research Strategies to utilize iPS cells for hair follicle regeneration and the treatment of hair loss disorders
This review discusses the potential of human induced pluripotent stem cells for regenerating hair follicles and developing cell-based therapies for hair loss, but it reports no new clinical results.
research 459 Estetrol prevents catagen progression in healthy and female pattern hair loss hair follicles ex vivo
Estetrol may help prevent hair loss and support hair growth in women.
research Apoptosis in follicles of individuals with female pattern hair loss is associated with perifollicular microinflammation
This study found that apoptosis was more prevalent in hair follicles of women with female pattern hair loss, particularly in miniaturized follicles, and was associated with follicular inflammation.
research Loss of Gata6 causes dilation of the hair follicle canal and sebaceous duct
This study suggests that the transcription factor Gata6 plays a role in maintaining the structure of the upper hair follicle and may be implicated in conditions marked by its abnormal expansion, such as acne or cystic diseases.
research Sulfotransferase activity in plucked hair follicles predicts response to topical minoxidil treatment in Brazilian female pattern hair loss patients
Hair enzyme activity predicts minoxidil success in Brazilian women with hair loss.
research 244 Defective maintenance of hair follicle stem cells through COL17A1 loss orchestrates the hair follicle aging program
Loss of COL17A1 causes hair follicle stem cells to age and leads to hair loss.
research Cell Therapy of Hair Loss: The Need of In Vitro Test Systems to Evaluate Follicle Formation
This review covers the potential of human hair follicle cloning for hair loss treatment, noting advancements in related scientific fields, and reports no new experimental findings.
research Resident T cell activation leads to human hair follicle immune privilege loss ex vivo, which is prevented by the DHODH inhibitor farudodstat: relevance for alopecia areata
This study found that activating hair follicle resident T cells in a human organ culture can induce an alopecia areata-like immune response, and that the drug farudodstat partially reduced this effect.
research The Hair Follicle and Hair Loss: A Review of DHT, Inflammation, Oxidative Stress, Vascular Signalling and the Biological Pathways Behind Hair Growth
This review suggests that hair loss involves a complex interplay of androgen signaling with various regenerative and inflammatory pathways, challenging the view of dihydrotestosterone as the sole cause.
research The Hair Follicle and Hair Loss: A Review of DHT, Inflammation, Oxidative Stress, Vascular Signalling and the Biological Pathways Behind Hair Growth
This narrative literature review by LUSTRAO examines the complex biological mechanisms influencing hair growth and loss, highlighting that androgen signalling, while significant, works within a network involving regenerative, inflammatory, and vascular processes, without establishing it as the sole explanation for conditions like androgenetic alopecia.
research Anti-Hair Loss Activity of Healthy Human Scalp-Derived Staphylococcus capitis KMH304 Ferment Filtrate in Human Hair-Follicle Dermal Papilla and Keratinocyte Cells
This study suggests that Staphylococcus capitis ferment filtrate (SCFF) may promote hair growth and scalp health by modulating pathways related to hair loss, aging, and oxidative stress in vitro.
research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression (Catagen) by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla
This study found that the retinoid all-trans retinoic acid induced a catagen-like stage in human scalp hair follicles, suggesting upregulation of TGF-beta2 as a contributing mechanism.
research Pten loss in Lgr5+ hair follicle stem cells promotes SCC development
This study found that loss of the Pten gene in Lgr5+ hair follicle stem cells promoted squamous cell carcinoma formation through the Akt/β-catenin signaling pathway.
research Regenerative medicine and hair loss: how hair follicle culture has advanced our understanding of treatment options for androgenetic alopecia
This review discusses advancements in cell culture techniques for hair growth treatments and provides insights into the potential and challenges of follicular cell implantation, reporting no new clinical results.
research Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells
This study found that loss of the ACER1 gene in mice led to increased ceramide levels and progressive hair loss, highlighting ACER1's role in maintaining hair follicle stem cell homeostasis.
research Oral minoxidil bio‐activation by hair follicle outer root sheath cell sulfotransferase enzymes predicts clinical efficacy in female pattern hair loss
Minoxidil activation by hair enzymes predicts treatment success for female hair loss.