Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that overexpression of the anti-apoptotic protein Bcl-2 in mice disrupted cell death during the hair cycle, impairing hair regeneration by delaying anagen entry and hair growth.

This study used porcine models to isolate and culture stem cells from brain and hair follicles, shedding light on differentiation processes and potential markers for stem cell compartments under lab conditions.

Results are not reported in this study, which investigated the effects of radiation on hair follicles and evaluated various cellular responses and signaling pathways, particularly focusing on WNT signaling and the impact of Wnt3a treatment.

This article reviews the current understanding of the localization, characteristics, and potential markers of epidermal stem cells, and reports no new experimental results.

This study found that αvβ6 integrin inhibits keratinocyte proliferation during wound healing and hair regeneration, suggesting its downregulation may enhance recovery and influence epidermal stem cell behavior.

This review discusses the potential of stem cell-based therapies, particularly involving stem cell-derived conditioned medium and exosomes, for hair regeneration in nonscarring alopecia, but it reports no new clinical outcomes.

In this study using C57BL/6N mice, the researchers found that skin thickness, mast cell counts, and immunoreactive density of certain cytokines increased at various stages of hair follicle growth following depilation.

This review explores the role of lymphatic vessels in skin regeneration and hair follicle growth, emphasizing their interactions with hair follicle stem cells and potential implications for regenerative therapies, but reports no new clinical results.

In this study, researchers found that minoxidil nanocrystals delivered using MG-MXD@NP, containing methylcellulose and gum arabic, significantly improved hair growth in mice compared to a standard minoxidil lotion, with enhanced delivery to skin tissues and increased markers of hair follicle stem cell activity.

This review discusses the genetic factors involved in hair follicle morphogenesis and cycling and reports no new clinical results; it emphasizes the role of genes in hereditary hair diseases.

This study found that while calcium can substitute for the Vitamin D receptor in maintaining epidermal keratinocyte differentiation, it cannot compensate for hair follicle dysfunction caused by the absence of the receptor.

This study found that Bcl-xL deficiency in mice increased apoptosis and resistance to skin tumor development, highlighting Bcl-xL's role in early skin carcinogenesis through anti-apoptotic functions.

This article reviews the role of stem cells and cytokines in hair growth and discusses existing and potential treatments, but it presents no new clinical data.

This study found that hemoglobin α is upregulated in epidermal keratinocytes after UV exposure and may function as an antioxidant, particularly for hair follicle stem cells.

This study reported that NRP2 expression in melanocytes and melanocyte stem cells is linked to migration inhibition and potentially melanoma progression, suggesting its role as a target for understanding melanoma and hair follicle biology.

Ovol2 is essential for normal skin and hair regeneration.

This article discusses the anatomical and biological aspects of hair follicle stem cells in the bulge region but reports no new research findings.

In this study using a mouse model, ECM/SVF-CM, derived from adipose-derived stem cells, was observed to stimulate hair growth more effectively than SVF-CM by promoting cell proliferation, neovascularization, and anagen induction, which may support its potential as an improved treatment for hair loss.

This study observed that treating hair follicles with BM15766 and 7DHC led to structural damage, disrupted cellular organization, reduced expression of key genes and proteins, and increased apoptosis, in contrast to controls, indicating detrimental effects on hair follicle integrity.

This study claims that the upper dermal sheath of rat vibrissa follicles can induce hair growth under specific conditions, challenging prior beliefs about its lack of inductive capacity.

This study found that photodynamic therapy achieved permanent removal of nonpigmented hair in mice after multiple sessions, unlike laser treatment, which was not effective for nonpigmented hair.

This review suggests that platelet-rich plasma may be effective in increasing hair density in patients with androgenetic alopecia, but more research is needed to determine the best treatment protocol.

This study found that Schistosoma mansoni cercariae stimulate epidermal keratinocytes in mice, initiating pro-inflammatory responses and barrier repair mechanisms akin to those in wound healing.

This review discusses the diverse applications of platelet-rich plasma in aesthetic dermatology and assesses the existing literature on its effectiveness, reporting no new clinical results.

This study found that ablating cyclin D3 in a Ras-dependent skin carcinogenesis model increased apoptosis in hair follicles, reducing papilloma development but potentially facilitating malignant progression when CDK6 is overexpressed.

This review discusses androgenetic alopecia and reports no clinical findings; the authors highlight a need for further research.

This study demonstrated that human iPSC-derived melanocytes, when transplanted into mice, can reconstitute pigmented hair follicles and integrate into normal tissue, suggesting their potential as a cellular therapy for depigmentation.

In this study using mice, simultaneous deficiencies in claudin-1 and claudin-3 were associated with hair loss and altered hair follicle architecture during the telogen phase, suggesting a role in hair retention.

This study found that loss of contact between the arrector pili muscle and the hair follicle bulge may explain why hair loss in male and female pattern baldness is largely irreversible, unlike in alopecia areata.

Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.