April 2024 in “Skin health and disease” In this pilot study, participants with lymphocytic primary cicatricial alopecia who applied 6% topical gabapentin solution twice daily for 12 weeks experienced significant symptom reduction, though there was no noticeable change in nerve fibre density or neuropeptide expression.
January 2024 in “Journal of the American Academy of Dermatology” Gabapentin helps with scalp itch, dutasteride works for frontal fibrosing alopecia, and more research is needed for better PCA treatments.
January 2024 in “Revista Dermatológica Centro Uraga” This report describes two male patients with frontal fibrosing alopecia, a lymphocytic scarring hair loss condition often seen in postmenopausal women, highlighting its occurrence in men and its manifestation around the frontal hairline and other body areas.
This study found that home use of low-level light therapy reduced inflammation and symptoms like itching and burning in women with frontal fibrosing alopecia over six months.
This study found a significant discordance between clinical symptoms and dermatoscopic signs with histopathological inflammation in patients with LPP and AFF, affecting diagnostic and therapeutic approaches.
March 2022 in “Más dermatología” This report discusses the potential overlap between chronic cutaneous lupus and frontal fibrosing alopecia, noting ongoing debate over the significance of their association without presenting new clinical results.
January 2022 in “Investigative News in Education (Universidad de Costa Rica)” This study found that consensus was not reached among Costa Rican dermatologists on diagnosis and treatment criteria for lichen planopilaris and frontal fibrosing alopecia using the Delphi method.
October 2021 in “Experimental Dermatology” This study explores the use of in silico methods to identify potential diagnostic biomarkers for primary cicatricial alopecia, revealing significant interactions among genes and proteins related to disease pathogenesis.
September 2021 in “Revista Interdisciplinar em Saúde” In this observational study, treatment with oral isotretinoin was reported to stabilize hair loss in patients with frontal fibrosing alopecia, offering potential guidance for clinicians on its therapeutic use, with implications for improving affected patients' self-esteem.
September 2021 in “Revista interdisciplinar em saúde” This study reported that oral isotretinoin effectively stabilized frontal fibrosing alopecia in patients, which may help guide healthcare providers in managing this condition related to hair loss and self-esteem.
March 2018 in “Dermatología Argentina” This study found that postmenopausal women in Argentina with frontal fibrosing alopecia had a higher average age of diagnosis than previously reported, with similar clinical features to international cases.
Lichen planopilaris and frontal fibrosing alopecia are likely the same disease with different clinical appearances.
November 2012 in “Annales de Dermatologie et de Vénéréologie” This report describes the first known pediatric cases of frontal fibrosing alopecia, a condition typically affecting postmenopausal women, highlighting its occurrence in children including female twins.
November 2012 in “South African Family Practice” This article describes the phases of the hair cycle in detail but reports no new clinical findings or results related to alopecia.
May 2011 in “Dermatología argentina” In this case report, a female patient with frontal fibrosing alopecia and lichen scleroatrophicus vulvae experienced excellent results from hair microtransplants combined with finasteride and topical minoxidil, maintained over six years.
This study reviewed the etiology, mechanisms, and treatments of scarring alopecias and noted that early and accurate identification is crucial due to overlapping features among different types, making differential diagnosis challenging.
29 citations
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September 2014 in “American Journal of Dermatopathology” This study found that horizontal sections of scalp biopsies in patients with Central Centrifugal Cicatricial Alopecia often reveal follicular miniaturization, inflammation, and scarring, which can guide personalized treatment.
28 citations
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April 2021 in “Biomedicines” This review evaluates in vitro hair follicle models, techniques, and challenges without reporting new clinical results, emphasizing their future potential in hair transplantation.
25 citations
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June 2018 in “Journal of The American Academy of Dermatology” This study identified upregulation of genes linked to fibroproliferative disorders, such as platelet-derived growth factor and collagen genes, in patients with central centrifugal cicatricial alopecia, suggesting potential therapeutic targets.
24 citations
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January 2020 in “JAAD Case Reports” This article discusses the staging of central centrifugal cicatricial alopecia in women of African descent and reports no new clinical results.
11 citations
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January 2022 in “Experimental Dermatology” This study suggests that patients with severe, extensive central centrifugal cicatricial alopecia may exhibit a distinct gene expression pattern in the lesional scalp, highlighting potential targets for future research on disease severity and therapies.
9 citations
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January 2010 in “International Journal of Trichology” This study found that in Alopecia Areata, increased non-anagen terminal follicles and peribulbar lymphocytic infiltrate are consistent histological features, even in cases that have progressed to scarring.
3 citations
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April 2018 in “Journal of Investigative Dermatology” CCCA may be a fibroproliferative disorder, and anti-fibrotic therapies could help.
December 2025 in “Cureus” This case report highlights that scarring alopecia with features of dystrophic epidermolysis bullosa and lichen planopilaris can occur in patients with a COL7A1 mutation, emphasizing the need to recognize concurrent inflammatory causes.
September 2024 in “JAMA Dermatology” In this case series, low-dose oral metformin was associated with improvements in symptoms and gene expression changes in Black female patients with treatment-resistant central centrifugal cicatricial alopecia, suggesting a potential therapeutic role for metformin in managing this condition.
March 2019 in “Nasza Dermatologia Online” A man had both alopecia areata and lichen planus, which is uncommon.
September 2017 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This case report suggests that in African-American patients, the histology of Central Centrifugal Cicatricial Alopecia may resemble lichen planopilaris, indicating a potential diagnostic challenge.
February 2017 in “The Journal of Sexual Medicine” This study found that young men using finasteride for androgenic alopecia exhibited erectile tissue fibrosis and associated sexual dysfunction, including low libido and mood changes.
December 2016 in “The Journal of Sexual Medicine” This study found that young men using finasteride for androgenic alopecia experienced erectile dysfunction and signs of erectile tissue fibrosis, alongside symptoms like low libido and mood changes.
64 citations
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June 2014 in “Journal of The American Academy of Dermatology” This study found that a peripilar white gray halo around hair emergence is a highly specific and sensitive dermatoscopic feature for diagnosing central centrifugal cicatricial alopecia in African American patients with mild central thinning.