Search

for
Search:

Did you mean FGF signaling?

Glossary FGF signaling

fibroblast growth factors bind to receptors, triggering cellular processes

FGF signaling, or Fibroblast Growth Factor signaling, is a biological pathway where fibroblast growth factors bind to their receptors on cell surfaces, triggering a cascade of cellular processes. This pathway is crucial for various functions, including cell growth, wound healing, and development of tissues and organs. In the context of hair, FGF signaling plays a significant role in hair follicle development and regeneration.

Related Terms

Sort by

Research

30 / 1000+ results

research FGF signaling is required for initiation of feather placode development

66 citations , June 2004 in “Development”

This study found that FGF signaling is necessary for the initiation of feather placode development in chicken embryos, with FGF10 being implicated as an early dermal signal in the process.

research FGF signaling for hair cycle resting phase alleviates radiation alopecia

1 citations , September 2016 in “Journal of Dermatological Science”

This study found that FGF18 signaling helps protect hair follicles from radiation damage by maintaining the resting phase and supporting stem cell survival, potentially reducing radiation-induced hair loss.

research BMP-FGF Signaling Axis Mediates Wnt-Induced Epidermal Stratification in Developing Mammalian Skin

84 citations , October 2014 in “PLoS Genetics”

This study found that epidermal Wnt production is crucial for forming the skin's spinous layer through a BMP-FGF signaling cascade, although Wnt from basal cells is not needed for their differentiation.

research Sprouty/FGF signaling regulates the proximal–distal feather morphology and the size of dermal papillae

50 citations , September 2012 in “Developmental Biology”

This study found that over-expressing Spry4 and Fgf10 modulates feather stem cells to alter feather morphologies in distinct ways, affecting barb branch formation and tissue structure.

research Activation of EGF and FGF signaling in developing mouse skin inhibits hair follicle morphogenesis

January 2007

EGF and FGF signaling stops hair follicle development in mice.

research Cooperation of TGF‐β and FGF signalling pathways in skin development

23 citations , May 2023 in “Cell Proliferation”

This review highlights the critical role of TGF-β and FGF signaling pathways in the development and regeneration of skin layers, particularly the dermis, and discusses their significance in advancing future clinical applications in dermatology.

Disruption of the Hedgehog Signaling Pathway Contributes to Hair Follicle Cycling Deficiency in VDR Knockout Mice

research Disruption of the hedgehog signaling pathway contributes to the hair follicle cycling deficiency in Vdr knockout mice

53 citations , May 2010 in “Journal of Cellular Physiology”

This study found that mice lacking the Vitamin D receptor showed disrupted hair follicle cycling, which was partially restored with hedgehog signaling pathway activation, suggesting a role for this pathway in follicle regulation independent of vitamin D.

3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling

research 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling

26 citations , October 2016 in “Biomolecules & Therapeutics”

This study found that 3-Deoxysappanchalcone may stimulate hair growth in mice by promoting proliferation of hair follicle dermal papilla cells through WNT/β-catenin and STAT signaling modulation.

research Eclipta prostrata promotes the induction of anagen, sustains the anagen phase through regulation of FGF-7 and FGF-5

7 citations , January 2019 in “Pharmaceutical Biology”

This study suggests that Eclipta prostrata may promote hair growth in mice and human dermal papilla cells through regulating FGF-7 and mTOR signaling.

research Defining ovine dermal papilla cell markers and identifying key signaling pathways regulating its intrinsic properties

5 citations , February 2023 in “Frontiers in Veterinary Science”

This study found that ovine dermal papilla cells exhibit robust aggregation and alkaline phosphatase activity, regulated by Wnt/β-catenin signaling, providing insights for improving wool performance and hair regeneration therapies.

research 839 Spatiotemporal antagonism in mesenchymal-epithelial Signaling in sweat versus hair fate decision

April 2017 in “Journal of Investigative Dermatology”

This study identified that in mice, sweat gland development is directed by mesenchymal signals that suppress SHH-production, while in humans, this occurs through a BMP spike in embryonic development.

research FGF18 signaling determines radioresistance of telogen hair follicles by the arrest of hair cycling

September 2016 in “Journal of dermatological science”

This study suggests that FGF18 may enhance radioresistance in telogen hair follicles by inducing cell cycle arrest, potentially serving as a radioprotector against radiation-induced hair follicle damage.

research Recombinant Type XVII Collagen Promotes Hair Growth by Activating the Wnt/β-Catenin and SHH/GLI Signaling Pathways

July 2025 in “Cosmetics”

This study found that recombinant human type XVII collagen (rhCOL17A1) promotes hair growth by activating the Wnt/β-catenin and SHH/GLI signaling pathways and increasing type XVII collagen expression, with significant effects observed in both cell and mouse models.

research Careless talk costs lives: fibroblast growth factor receptor signalling and the consequences of pathway malfunction

119 citations , November 2014 in “Trends in Cell Biology”

This review discusses the mechanisms and pathways of FGFR signalling and its roles in development, disorders, and therapeutic targeting, but reports no new clinical results.

research Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration

21 citations , June 2016 in “PloS one”

This study found that MYC and FGF pathways are crucial for hair cell regeneration in chick and zebrafish models, suggesting potential targets for promoting hair cell regeneration in mammals.

Androgenetic Alopecia: Combing the Hair Follicle Signaling Pathways for New Therapeutic Targets and More Effective Treatment Options

research Androgenetic alopecia: combing the hair follicle signaling pathways for new therapeutic targets and more effective treatment options

19 citations , August 2019 in “Expert Opinion on Therapeutic Targets”

This review discusses emerging targets for developing drugs to treat hair loss and reports no new clinical results; the authors emphasize the potential for therapies that regenerate hair follicles.

research Hairy tale of signaling in hair follicle development and cycling

161 citations , August 2012 in “Seminars in cell & developmental biology”

This review discusses the molecular mechanisms involved in hair follicle development and regeneration, highlighting findings from mouse genetic studies, and reports no new experimental results.

Feather Arrays Are Patterned by Interacting Signaling and Cell Density Waves

research Feather arrays are patterned by interacting signalling and cell density waves

133 citations , February 2019 in “PLoS Biology”

This research found that feather pattern formation in birds is regulated by a mechanochemical system involving fibroblast growth factor and bone morphogenetic protein signaling, which is altered in the flightless emu and ostrich.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations , February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

The researchers reported that adenosine increases FGF-7 expression in dermal papilla cells, which may stimulate hair growth via the A2b adenosine receptor and cAMP pathway.

Nitrate Promoting Hair Growth Through Enhancing Wnt/β-Catenin and Downregulating TGF-β/Smad/BMP Signaling Pathway in C57BL/6 Mice

research Nitrate Promoting Hair Growth Through Enhancing Wnt/β-catenin and Downregulating TGF-β/Samd/BMP signaling pathway in C57BL/6 Mice

November 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

In this mouse study, nitrate supplementation at 10mM was observed to significantly promote hair growth by increasing hair follicle number and dermis thickness, and it may work by activating the Wnt/β-catenin pathway and inhibiting TGF-β1 signaling.

research Hierarchical patterning modes orchestrate hair follicle morphogenesis

149 citations , July 2017 in “PLoS Biology”

This study found that hair follicle patterning in development may arise from a combination of epidermal prepattern signals and mesenchymal self-organisation, with fibroblast growth factor and bone morphogenetic protein activities playing key roles.

research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction

32 citations , April 2016 in “Journal of Investigative Dermatology”

This study found that STAT5 activation in the dermal papilla acts as a key switch to trigger anagen entry in postdevelopmental hair follicle cycling.

research Mutation of the GDP-Fucose Biosynthesis Gene gmds Increases Hair Cell Number and Neuromast Regenerative Capacity in Zebrafish

1 citations , October 2025 in “International Journal of Molecular Sciences”

This study found that zebrafish with a mutation in the GDP-fucose biosynthesis gene exhibited enhanced and faster regeneration of mechanosensory hair cells, implicating the importance of this gene and Notch signalling regulation in hair cell regeneration mechanisms.

research 1362 The role of Fgf20 in establishing the hair follicle dermal condensate

April 2018 in “Journal of Investigative Dermatology”

This study found that Fgf20 signaling facilitates fibroblast migration and influences dermal condensate cell development during hair follicle morphogenesis by supporting cellular activities such as cell cycle exit and specific cell shape adoption.

research The stem cell niche

209 citations , October 2008 in “The Journal of Pathology”

This review discusses the niches supporting adult stem cells in various organisms, including well-studied germline niches and the less understood mammalian niches, but it reports no new research findings.

research Micro‐RNA‐31 controls hair cycle‐associated changes in gene expression programs of the skin and hair follicle

149 citations , June 2010 in “The FASEB journal”

In this study, miR-31 was found to play a significant role in hair cycle regulation in mice by controlling key gene expressions involved in hair growth and differentiation.

research TNF superfamily in skin appendage development

86 citations , May 2008 in “Cytokine & growth factor reviews”

This review discusses recent discoveries about the role of Eda and other TNF-related cytokines in skin appendage development and reports no new experimental results, highlighting developments since the last comprehensive summary in 2003.

research Transcriptome Reveals Long Non-coding RNAs and mRNAs Involved in Primary Wool Follicle Induction in Carpet Sheep Fetal Skin

37 citations , May 2018 in “Frontiers in physiology”

This study identified key long non-coding RNAs and mRNAs involved in primary wool follicle induction in carpet wool sheep, emphasizing their roles in hair follicle development and skin processes.

research Regeneration of hair and other skin appendages: A microenvironment‐centric view

10 citations , June 2016 in “Wound Repair and Regeneration”

This review explores the regenerative potential of hair follicles and their role in complete skin regeneration, emphasizing the influence of mechanical factors and niche signaling pathways on hair growth and loss.

research Male androgenetic alopecia is due to hair follicle stem cell inactivation

3 citations , April 2011 in “Expert Review of Dermatology”

This review examines a study showing that the balding scalp in men with androgenetic alopecia retains stem cells but lacks certain progenitor cells, suggesting new targets for future therapies; it reports no clinical results.