295 citations
,
May 2016 in “Journal of the American Academy of Dermatology” This review examines the immunological aspects of alopecia areata, focusing on genetic, neuroimmunological, and immune privilege factors, but does not report new clinical findings.
291 citations
,
January 2014 in “The Scientific World Journal” Lichen Planus is a less common condition affecting skin and mucous membranes, with various types and associated risk factors, challenging to diagnose, significantly impacts life quality, and may have a risk of cancerous changes in oral lesions.
218 citations
,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that removing PPARγ specifically from mouse adipose tissue led to severe fat loss, insulin resistance, diabetes, and associated metabolic abnormalities.
218 citations
,
December 2011 in “Advances in Urology” This review discusses the biochemical properties and clinical significance of 5 alpha-reductase isozymes and reports no new clinical results.
202 citations
,
January 2022 in “Journal of Clinical Medicine” This study found that female COVID-19 survivors were more likely than males to experience multiple long-term post-COVID symptoms, including fatigue, pain, hair loss, and mood disorders.
200 citations
,
October 2009 in “European journal of endocrinology” This review discusses the multifaceted actions of metformin in polycystic ovary syndrome and reports no new clinical results; the authors emphasize metformin's potential benefits in both cardiometabolic and reproductive aspects of PCOS.
196 citations
,
March 2016 in “Nature Communications” In this study, researchers identified 18 genetic associations with scalp and facial hair traits in Latin Americans, including novel loci for hair greying and balding, with implications for understanding hair evolution.
179 citations
,
November 2022 in “Frontiers in Plant Science” This review summarizes the roles of WRKY transcription factors in plant growth and their responses to various environmental stresses, but reports no new experimental findings.
157 citations
,
May 2016 in “Plastic and reconstructive surgery/PSEF CD journals” This review of facial feminization surgery literature suggests it is generally safe and satisfactory for patients, though more research is needed to establish best practices and quality-of-life outcomes.
149 citations
,
December 2007 in “The Journal of Clinical Endocrinology and Metabolism” Women with PCOS have overall higher body fat, not abnormal fat placement, and more insulin resistance.
134 citations
,
June 2012 in “International Journal of Oral and Maxillofacial Surgery” This article discusses current methods in facial feminization surgery for transsexual women and reports no new clinical results, focusing instead on various surgical techniques used to feminize facial features.
133 citations
,
July 2006 in “International Journal of Dermatology” This study found that topical eflornithine HCl 13.9% cream effectively reduced facial hair in women, with a favorable safety profile.
131 citations
,
September 2010 in “The Laryngoscope” This study found that forehead feminization significantly contributes to recognizing female gender and reported that feminizing forehead cranioplasty is a safe procedure with a low complication rate.
125 citations
,
February 2007 in “Journal of the American Academy of Dermatology” This study found that adding topical eflornithine to laser hair removal significantly improved the reduction of unwanted facial hair in women over a 6-month period, compared to laser treatment alone.
124 citations
,
March 2012 in “JAMA” This abstract discusses the unclear role of dihydrotestosterone (DHT) in postembryonic life in marsupials and possibly humans, reporting no new findings.
119 citations
,
November 2009 in “Human Reproduction” This study found that women with polycystic ovary syndrome have a higher prevalence of non-alcoholic fatty liver disease and increased androgen bioavailability may be involved alongside metabolic factors.
115 citations
,
April 2010 in “Archives of Dermatology” In this randomized, blinded study, the surgical face-lift improved facial skin laxity by 49% compared to 16% with a minimally invasive fractional radiofrequency treatment, with FRF causing fewer adverse effects.
104 citations
,
January 2022 in “Materials Today Bio” This study explored the development of zinc-incorporated gelatin-based hydrogels, which demonstrated strong antibacterial properties and supported skin cell health, ultimately improving the healing process of S. aureus-infected full-thickness wounds, showing promise as wound dressings for infected wounds.
96 citations
,
December 2018 in “Immunity” This study found that inhibiting TGF-β receptors in adult dermal fibroblasts restored their function and increased resistance to Staphylococcus aureus infection by enhancing their adipogenic and antimicrobial capabilities.
93 citations
,
April 2003 in “Proceedings of the National Academy of Sciences of the United States of America” This study identified an unexpected critical role for the FATP4 protein in skin and hair development in mice, linking it to a potential candidate gene for restrictive dermopathy in humans.
88 citations
,
August 2014 in “PLOS genetics” This study found that mice lacking syndecan-1 experienced cold stress and metabolic issues due to reduced intradermal fat, which was restored by thermoneutral housing or rosiglitazone treatment.
78 citations
,
February 2024 in “ACS Omega” This study developed a bilayer material combining poly(vinyl alcohol) and bacterial cellulose with a gelatin-poly(vinyl alcohol) hydrogel, showing strong potential as a wound dressing due to its good antibacterial properties, cell viability, and sustained drug release.
78 citations
,
August 1996 in “The Journal of Clinical Endocrinology & Metabolism” This study reports that the same androgen receptor gene mutation within a family can lead to both complete and partial androgen insensitivity syndromes, suggesting that genetic defects alone may not predict clinical phenotype.
76 citations
,
November 2010 in “Journal of The American Academy of Dermatology” In this study, a photographic scale and questionnaire revealed that extensive central scalp hair loss was observed in 5.6% of African American women, with an association to a history of tinea capitis.
70 citations
,
February 2019 in “The journal of immunology/The Journal of immunology” This study found that short-chain fatty acids produced by the skin microbe Propionibacterium acnes may drive inflammatory gene expression in sebocytes, potentially contributing to acne.
69 citations
,
December 2016 in “Facial plastic surgery” This review discusses the anatomical and histological characteristics of facial fat compartments and reports no new clinical results, emphasizing a need for further research on their role in facial aging.
68 citations
,
March 2019 in “Journal of Cranio-Maxillofacial Surgery” This study validated a facial aging scale that predicts patients' age with good reliability and validity, potentially serving as a useful tool for assessing facial rejuvenation treatments and clinical research.
66 citations
,
September 2008 in “The Journal of Dermatology” This study found that gastrointestinal dysfunction is a significant risk factor for sebaceous gland diseases in adolescents, with correlations observed between these conditions and various GI symptoms.
65 citations
,
January 2018 in “Nature Reviews Endocrinology” This review discusses the unique features of dermal white adipose tissue, its interaction with hair follicles, and its role in skin physiology, reporting no new experimental findings.
65 citations
,
December 1986 in “The Journal of Clinical Endocrinology & Metabolism” This study concluded that a 26-year-old woman had autosomal dominantly inherited hereditary cortisol insensitivity, leading to increased adrenocortical cortisol and androgen secretion, which caused clinical symptoms unlike in her male relatives.