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Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Calreticulin has roles in healing, immune response, and disease beyond its known functions in the endoplasmic reticulum.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Frontal fibrosing alopecia is a hair loss condition in postmenopausal women, similar to lichen planopilaris, with ineffective treatments.

Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

β-catenin in the dermal papilla is crucial for normal hair growth and repair.

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.

Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

Stromal stem cells may help heal wounds by becoming structural cells or affecting the immune system, but more research is needed to understand how.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

Adult stem cells from rat whisker follicles can regenerate hair follicles and sebaceous glands.

The modified Ferriman-Gallwey method is a useful tool for diagnosing hirsutism.

Women with the NIH type of PCOS have more obesity and higher risk of diabetes and heart disease than those with other types of PCOS.

The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.

Wnt signaling is crucial for pigmented hair regeneration by controlling stem cell activation and differentiation.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

PCOS is a complex disorder in women that can lead to various health risks and requires personalized treatment.

Growing human skin cells in a 3D environment can stimulate new hair growth.

The NAMS 2014 recommendations guide healthcare providers on treating health issues in midlife women, emphasizing individualized care and informed decision-making.

The immune system plays a key role in tissue repair, affecting both healing quality and regenerative ability.

Ectodin integrates BMP, SHH, and FGF signals in developing ectodermal organs.

Blocking the enzyme 5α-reductase can shrink the prostate and help treat enlarged prostate issues.

Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.

Stem cells are crucial for skin repair and new treatments for chronic wounds.

Acne affects most teenagers and can continue into adulthood, with various treatments available that show improvement but have concerns like antibiotic resistance and side effects.

Guidelines suggest various treatments for alopecia areata, but leaving it untreated is also an option as 80% cases may recover on their own.

More dermal papilla cells in hair follicles lead to larger, healthier hair, while fewer cells cause hair thinning and loss.