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GlossaryERK Pathway

chain of proteins transmitting signals from cell surface to DNA

The ERK Pathway, also known as the Extracellular Signal-Regulated Kinase Pathway, is a chain of proteins in the cell that communicates signals from a receptor on the cell's surface to the DNA in the nucleus. This pathway plays a crucial role in regulating various cellular activities, including growth, division, and differentiation. It is particularly important in the context of hair biology, as disruptions in this pathway can influence hair growth and contribute to conditions like alopecia.

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Combination of Herbal Extracts and Platelet-Rich Plasma Induced Dermal Papilla Cell Proliferation: Involvement of ERK and Akt Pathways

research Combination of Herbal Extracts and Platelet-Rich Plasma Induced Dermal Papilla Cell Proliferation: Involvement of ERK and Akt Pathways

39 citations, June 2013 in “Journal of Cosmetic Dermatology”

Herbal extracts and platelet-rich plasma together may help increase hair growth by making certain cells grow more, through specific cell growth pathways.

research Undariopsis Peterseniana Promotes Hair Growth by the Activation of Wnt/β-Catenin and ERK Pathways

27 citations, May 2017 in “Marine Drugs”

Undariopsis peterseniana extract helps hair grow by activating certain cell growth pathways and could be a new treatment for hair loss.

research VEGF Upregulates VEGF Receptor-2 on Human Outer Root Sheath Cells and Stimulates Proliferation Through ERK Pathway

23 citations, June 2012 in “Molecular Biology Reports”

VEGF stimulates hair cell growth and increases growth receptor levels through a specific signaling pathway.

research Myristoleic Acid Promotes Anagen Signaling by Autophagy Through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells

8 citations, February 2021 in “Biomolecules & therapeutics”

Myristoleic acid helps hair growth by boosting cell growth and recycling processes in hair follicle cells.

Wnt/β-Catenin and ERK Pathway Activation: The Possible Mechanism of Various LED Light Regulating the Proliferation of Human Outer Root Sheath Cells

research Wnt/β-Catenin and ERK Pathway Activation: The Possible Mechanism of Various LED Light Regulating the Proliferation of Human Outer Root Sheath Cells

May 2017 in “Journal of The American Academy of Dermatology”

LED light helps human hair root cells grow and move by activating certain cell pathways.

research P140 Light-Emitting Diode Light Regulates the Proliferation of Human Outer Root Sheath Cells via Wnt/β-Catenin and ERK Pathway

January 2016 in “프로그램북(구 초록집)”

LED light promotes hair growth by stimulating cell proliferation and reducing cell death.

Wnt/β-Catenin and ERK Pathway Activation: A Possible Mechanism of Photobiomodulation Therapy with Light-Emitting Diodes That Regulate the Proliferation of Human Outer Root Sheath Cells

research Wnt/β-Catenin and ERK Pathway Activation: A Possible Mechanism of Photobiomodulation Therapy with Light-Emitting Diodes That Regulate the Proliferation of Human Outer Root Sheath Cells

43 citations, September 2017 in “Lasers in Surgery and Medicine”

LED light therapy may help hair growth by activating certain cell pathways.

Bacillus/Trapa Japonica Fruit Extract Ferment Filtrate Enhances Human Hair Follicle Dermal Papilla Cell Proliferation via the Akt/ERK/GSK-3β Signaling Pathway

research Bacillus/Trapa Japonica Fruit Extract Ferment Filtrate Enhances Human Hair Follicle Dermal Papilla Cell Proliferation via the Akt/ERK/GSK-3β Signaling Pathway

10 citations, May 2019 in “BMC Complementary and Alternative Medicine”

The extract from Bacillus/Trapa japonica fruit helps increase hair growth and could be a potential treatment for hair loss.

research Involvement of Activation of Mitogen-Activated Protein Kinase (MAPK)/Extracellular Signal-Regulated Kinase (ERK) Signaling Pathway in Proliferation of Urethral Plate Fibroblasts in Finasteride-Induced Rat Hypospadias

10 citations, December 2018 in “Medical Science Monitor”

The MAPK/ERK pathway is crucial in controlling cell growth and death in finasteride-induced hypospadias.

Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in C57BL/6 Mice Through Upregulation of the RAS/ERK Signaling Pathway

research Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in C57BL/6 Mice Through Upregulation of the RAS/ERK Signaling Pathway

November 2024 in “Journal of Translational Internal Medicine”

Exosomes from stem cells help hair regrowth by activating a specific signaling pathway.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

24 citations, September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Methanol Extract of Peach Kernel Induces Human Hair Follicle Dermal Papilla Cell Proliferation via the Extracellular Signal-Regulated Kinase Signaling Pathway

research Methanol Extract of Peach Kernel Induces Human Hair Follicle Dermal Papilla Cell Proliferation via the Extracellular Signal-Regulated Kinase Signaling Pathway

January 2024 in “Indian Journal of Pharmaceutical Sciences”

Peach kernel extract may promote hair growth by boosting cell growth in hair follicles.

research Quercitrin Stimulates Hair Growth with Enhanced Expression of Growth Factors via Activation of MAPK/CREB Signaling Pathway

25 citations, September 2020 in “Molecules”

Quercitrin may help treat hair loss by promoting hair growth and improving cell health.

research Mackerel-Derived Fermented Fish Oil Promotes Hair Growth by Anagen-Stimulating Pathways

14 citations, September 2018 in “International Journal of Molecular Sciences”

Mackerel-derived fermented fish oil helps hair grow by activating growth pathways and increasing cell proliferation.

research Norgalanthamine Stimulates Proliferation of Dermal Papilla Cells via Anagen-Activating Signaling Pathways

5 citations, December 2018 in “Biological & Pharmaceutical Bulletin”

Norgalanthamine helps hair cells grow by activating certain pathways related to hair growth.

Wnt/B-Catenin and ERK Pathway Activation: The Possible Mechanism of Various Light-Emitting Diode Light Regulates the Proliferation of Human Outer Root Sheath Cells

research Wnt/B-Catenin and ERK Pathway Activation: The Possible Mechanism of Various Light-Emitting Diode Light Regulates the Proliferation of Human Outer Root Sheath Cells

May 2017 in “Journal of The American Academy of Dermatology”

LED light helps human hair root cells grow and prevents them from dying by activating specific growth pathways.

research Would You Recognize This Lesion as a Gumma Syphilitica?

June 2017 in “Journal of The American Academy of Dermatology”

LED light helps hair follicle cells grow and prevents them from dying by activating certain cell pathways.

research WWOX Deficiency Causes Downregulation of Prosurvival ERK Signaling and Abnormal Homeostatic Responses in Mouse Skin

6 citations, October 2020 in “Frontiers in cell and developmental biology”

WWOX deficiency in mice causes skin and fat tissue problems due to disrupted cell survival signals.

Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

research Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

28 citations, October 2011 in “International Journal of Molecular Medicine”

Adenosine helps hair grow longer and stronger by boosting certain growth factors and signaling pathways.

research Establishment of an Efficient Primary Culture System for Human Hair Follicle Stem Cells Using the Rho-Associated Protein Kinase Inhibitor Y-27632

16 citations, March 2021 in “Frontiers in cell and developmental biology”

A new method using Y-27632 improves the growth and quality of human hair follicle stem cells for tissue engineering and therapy.

The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development

research The Overexpression of Tβ4 in the Hair Follicle Tissue of Alpas Cashmere Goats Increases Cashmere Yield and Promotes Hair Follicle Development

16 citations, December 2019 in “Animals”

Overexpressing Tβ4 in goats' hair follicles increases cashmere production and hair follicle growth.

research Novel Effect of Sildenafil on Hair Growth

16 citations, October 2018 in “Biochemical and Biophysical Research Communications”

Sildenafil, often used for erectile dysfunction, may help hair growth.

research Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling

8 citations, June 2022 in “Frontiers in bioengineering and biotechnology”

A patch made from human lung fibroblast material helps heal skin wounds effectively, including diabetic ulcers.

Effect of Miscanthus Sinensis Var. Purpurascens Flower Extract on Proliferation and Molecular Regulation in Human Dermal Papilla Cells and Stressed C57BL/6 Mice

research Effect of Miscanthus Sinensis Var. Purpurascens Flower Extract on Proliferation and Molecular Regulation in Human Dermal Papilla Cells and Stressed C57BL/6 Mice

8 citations, May 2017 in “Chinese Journal of Integrative Medicine”

Miscanthus sinensis flower extract may help promote hair growth and prevent hair loss.