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    Glossary Epithelialization

    process of new skin cells covering a wound

    Epithelialization is the process by which new epithelial cells form and migrate to cover a wound or damaged tissue, creating a protective barrier. This is a crucial step in wound healing, as it helps to restore the integrity of the skin or mucous membranes, preventing infection and further injury.

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    1. A Simple In Vivo System for Studying Epithelialization, Hair Follicle Formation, and Invasion Using Primary Epidermal Cells from Wild-Type and Transgenic Ornithine Decarboxylase-Overexpressing Mouse Skin Journal of Investigative Dermatology · 2001 · 13 citations
    2. The Diameter Factor of Aligned Membranes Facilitates Cutaneous Wound Healing by Promoting Epithelialization in an Immune Way bioRxiv (Cold Spring Harbor Laboratory) · 2021 · 1 citations
    3. Platelet-rich plasma accelerates skin wound healing by promoting re-epithelialization Burns & Trauma · 2020 · 169 citations
    4. Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization Stem Cell Research & Therapy · 2020 · 65 citations
    5. Thyrotropin-Releasing Hormone (TRH) Promotes Wound Re-Epithelialisation in Frog and Human Skin PLOS ONE · 2013 · 46 citations
    6. Novel Biodegradable Polymeric Microparticles Facilitate Scarless Wound Healing by Promoting Re-epithelialization and Inhibiting Fibrosis Frontiers in Immunology · 2018 · 37 citations
    7. Thyroxine (T4) may promote re-epithelialisation and angiogenesis in wounded human skin ex vivo PLoS ONE · 2019 · 27 citations
    8. Moist exposed burn ointment accelerates diabetes-related wound healing by promoting re-epithelialization Frontiers in Medicine · 2023 · 24 citations
    9. Re-epithelialization of the skin following CO 2 laser resurfacing Journal of Cutaneous Laser Therapy · 2001 · 20 citations
    10. Follicular Isolation Technique with De-Epithelialization for Eyebrow and Eyelash Reconstruction Plastic and Reconstructive Surgery · 2012 · 12 citations
    11. The efficacy and safety of autologous epidermal cell suspensions for re‐epithelialization of skin lesions: A systematic review and meta‐analysis of randomized trials Skin Research and Technology · 2024 · 10 citations
    12. Inhibition of the CoREST Repressor Complex Promotes Wound Re-Epithelialization through the Regulation of Keratinocyte Migration Journal of Investigative Dermatology · 2023 · 8 citations
    13. Effect of De-epithelialization on Graft Survival Rate After Follicular Unit Extraction Dermatologic Surgery · 2021 · 1 citations
    14. Nanoclay gels promote re-epithelialization and improve the quality of skin wound healing in a diabetic mouse model npj Regenerative Medicine · 2026
    15. Negatively Charged Carbon Dot‐Linked Glycyrrhizic Acid Hydrogel Promoted Hemostasis, Immunoregulation and Re‐Epithelialization of Wound Closure Small · 2026
    16. The Utility of De-epithelialization in Subcutaneous Skin Flap Transposition. PubMed · 2025
    17. M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during dermal wound healing PLOS ONE · 2022
    18. M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during skin wound healing 2021
    19. Dendritic epidermal T cells secreting exosomes promote the proliferation of epidermal stem cells to enhance wound re-epithelialization Stem Cell Research & Therapy · 2022 · 24 citations
    20. DNA Damage-Inducible Transcript 4 Is an Innate Surveillant of Hair Follicular Stress in Vitamin D Receptor Knockout Mice and a Regulator of Wound Re-Epithelialization International journal of molecular sciences · 2016 · 22 citations
    21. ALKBH5-mediated m6A demethylation fuels cutaneous wound re-epithelialization by enhancing PELI2 mRNA stability Inflammation and Regeneration · 2023 · 8 citations
    22. Cultured Keratinocyte Sheets Enhanced Spontaneous Re-Epithelialization in a Dermal Explant Model of Partial-Thickness Wound Healing Journal of Investigative Dermatology · 1990 · 42 citations
    23. 658 The epigenetic control of re-epithelialization during adult skin wound healing Journal of Investigative Dermatology · 2024
    24. The Yin and Yang of Integrin Function in Re-Epithelialization During Wound Healing Advances in Wound Care · 2013 · 8 citations
    25. 1α,25-Dihydroxyvitamin D3 accelerates skin wound re-epithelialization by promoting epidermal stem cell proliferation and differentiation through PI3K activation: an in vitro and in vivo study Brazilian Journal of Medical and Biological Research · 2025 · 2 citations
    26. Combined Deletion of the Vitamin D Receptor and Calcium-Sensing Receptor Delays Wound Re-epithelialization Endocrinology · 2017 · 28 citations
    27. Hedgehog signaling is essential for normal wound healing Wound Repair and Regeneration · 2008 · 112 citations
    28. Reepithelialization of a Full-Thickness Burn from Stem Cells of Hair Follicles Micrografted into a Tissue-Engineered Dermal Template (Integra) Plastic and Reconstructive Surgery · 2004 · 87 citations
    29. Bio-multifunctional alginate/chitosan/fucoidan sponges with enhanced angiogenesis and hair follicle regeneration for promoting full-thickness wound healing Materials & Design · 2020 · 83 citations
    30. A pilot clinical study of hair grafting in chronic leg ulcers Wound Repair and Regeneration · 2012 · 63 citations