12 citations
,
January 2021 in “Dermatology Research and Practice” This study found that using a nonablative 1927 nm wavelength laser followed by hydroquinone cream is safe and effective for treating postinflammatory hyperpigmentation in patients with dark skin types.
August 2019 in “RIUnB Institutional Repository (University of Brasília)” This study developed polymer nanoparticles with and without chitosan coating to deliver dutasteride to hair follicles for treating androgenic alopecia. Both nanoparticle types showed controlled drug release and enhanced follicle targeting, especially with mechanical stimulus, supporting their potential as effective topical carriers in skin layers.
15 citations
,
November 2015 in “International Journal of Dermatology” This study found that keratin 14 may serve as an autoantigen in autoimmune skin diseases, indicated by its altered expression in affected skin and reactivity of patient sera.
18 citations
,
January 2013 in “Veterinary Dermatology” This study found that K15 is a useful marker for investigating the role of stem cells in canine hair follicle tumours, while nestin is not optimal.
9 citations
,
May 2002 in “PubMed” This study demonstrated that mice lacking skin-specific RXRalpha expression developed hair follicle degeneration and alopecia, indicating the importance of RXRalpha/VDR heterodimers in maintaining hair follicle homeostasis.
November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that YAP1 localization and expression patterns in human skin xenografts resembled pathological conditions, suggesting that YAP1 may be a potential target for treating skin pathologies.
July 2024 in “Journal of Investigative Dermatology” The new skin organoid system effectively mimics human skin for studying its functions, injuries, and diseases.
April 2023 in “Journal of Investigative Dermatology” This study found that blocking apoptosis during the catagen phase in mice disrupts hair follicle stem cell niche architecture, delaying subsequent hair regeneration cycles.
January 2026 in “Frontiers in biomedical technologies” In this study, high-resolution ultrasound imaging revealed that DHT administration in male C57BL/6 mice leads to increased epidermal and dermal thicknesses and decreased skin elasticity, simulating structural changes associated with Androgenetic Alopecia.
18 citations
,
June 1992 in “Acta Histochemica” Human hair follicles have a unique cell distribution and differentiation pattern during growth.
30 citations
,
September 2000 in “Journal of Dermatological Science” This study reports that the fatty acid composition in cell membranes of stratified squamous epithelium varies with keratinization patterns, showing a partial essential fatty acid-deficient state in cultured keratinocytes.
7 citations
,
March 1986 in “British Veterinary Journal” Canine skin has two main layers: the epidermis and dermis, with a supportive subcutis layer.
2 citations
,
June 2013 in “In Vitro Cellular & Developmental Biology - Animal” This study successfully cultured human fetal hair follicle-derived melanocytes, which showed high proliferative capabilities and unique morphological characteristics compared to adult-derived cells, potentially advancing hair disease research.
788 citations
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February 2007 in “Nature” This review explores how adult skin epithelia preserve stem cell populations for hair follicle regeneration and wound healing, but reports no new experimental results.
32 citations
,
December 1963 in “Pharmacological Reviews” This article reviews how various chemical agents affect human hair and skin, suggesting the need for more research on their pharmacologic and dermatologic effects; it does not report new experimental results.
149 citations
,
July 2000 in “Molecular and Cellular Biology” This study found that MK6a-deficient mice showed delayed reepithelialization after superficial wounding but not after full-thickness skin wounds, suggesting MK6a plays a role in activating follicular keratinocytes post-wounding.
December 2015 in “Dermatologic Surgery” Double trichophytic closure effectively repairs thin scalp scars, reducing financial burden.
101 citations
,
December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology” This study reports the successful differentiation of mouse induced pluripotent stem cells into keratinocytes that can regenerate skin and its structures in an in vivo environment.
5 citations
,
January 2019 in “Elsevier eBooks” This chapter reviews skin components, wound healing mechanisms, and the potential of biomaterials to enhance skin repair and regeneration, without offering new experimental results.
4 citations
,
July 2023 in “Experimental Dermatology” This study found that incorporating human adipose subcutaneous tissue in 3D organotypic skin cultures mimicking hypertrophic scar conditions improved epidermal homeostasis, formed a basement membrane similar to native skin, and reduced myofibroblast presence, indicating an anti-fibrotic effect.
7 citations
,
December 2004 in “Medicine” This article reviews the anatomy and pathology of skin and hair to aid in diagnosing skin diseases and discusses potential therapies, without reporting new clinical results.
211 citations
,
May 2018 in “Trends in cell biology” This review explores recent insights into the diverse cell populations involved in skin development, homeostasis, wound healing, and cancer progression but reports no new results.
55 citations
,
December 2014 in “Dermatologica sinica/Zhōnghuá pífūkē yīxué zázhì” This article discusses the interactions between keratinocytes and melanocytes in maintaining epidermal and hair follicle homeostasis, without reporting new experimental results.
32 citations
,
March 1988 in “International Journal of Dermatology” This review discusses current concepts on the role of retinoids in keratinization and does not report new clinical results; the authors emphasize the complexity of retinoid effects on skin.
26 citations
,
January 2022 The skin is essential for protection, temperature control, and immune defense.
22 citations
,
July 1998 in “Journal of Investigative Dermatology” This study identified and characterized a gene called 4C32, which is expressed in the periderm of embryonic mouse skin and has a structure similar to keratin-associated proteins.
17 citations
,
November 2000 in “Journal of Investigative Dermatology” ZPK helps skin cells mature and may affect skin health.
11 citations
,
April 1993 in “PubMed” In this study, trichocytes were shown to have potential for alternative differentiation, with mesenchymal cell influences playing a critical role in determining this process.
7 citations
,
January 1981 in “Springer eBooks” The document concludes that hair biology is complex and there are still unanswered questions about hair loss and follicle changes.
2 citations
,
August 2013 in “Journal of Investigative Dermatology” This review discusses the dynamic changes in chromatin organization and nuclear morphology during cellular processes like differentiation and disease, highlighting recent advances in understanding these epigenetic mechanisms without presenting new experimental findings.