55 citations,
March 2012 in “Journal of Investigative Dermatology” Research on epidermal stem cells has advanced significantly, showing promise for improved clinical therapies.
49 citations,
August 2004 in “The FASEB Journal” Mice with human skin protein K8 had more skin problems and cancer.
7 citations,
November 2014 in “Histochemistry and Cell Biology” The we/we wal/wal mice have defects in hair growth and skin layer formation, causing hair loss, useful for understanding alopecia.
2 citations,
August 2013 in “Journal of Investigative Dermatology” Nuclear shape and chromatin changes affect gene expression in skin cell differentiation.
December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” AP-2α and AP-2β proteins are essential for healthy adult skin and hair.
April 2017 in “Journal of Investigative Dermatology” The protein CTCF is essential for skin development, maintaining hair follicles, and preventing inflammation.
182 citations,
August 2016 in “Development” ATP-dependent chromatin-remodeling complexes are crucial for gene regulation, cell differentiation, and organ development in mammals.
32 citations,
March 2021 in “Journal of endocrinological investigation” Thyroid hormones are important for skin health and changes in them can affect conditions like hair loss and eczema.
9 citations,
March 2013 in “Expert opinion on biological therapy” Epidermal stem cells have potential for personalized regenerative medicine but need careful handling to avoid cancer.
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March 2012 in “Development” Skin needs dermal β-catenin activity for hair growth and skin cell multiplication.
6 citations,
December 2017 in “Molecular Medicine Reports” Wnt5a may contribute to psoriasis by reducing skin cell growth, blocking skin cell maturation, and increasing inflammation.
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May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” ELL is crucial for gene transcription related to skin cell growth.
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January 2011 in “Development” Adam10 enzyme is crucial for healthy skin and proper Notch signaling.
83 citations,
May 2013 in “International Journal of Molecular Sciences” Skin development in mammals is controlled by key proteins and signals from underlying cells, involving stem cells for maintenance and repair.
41 citations,
April 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” Deleting MED1 in skin cells causes hair loss and skin changes.
January 2023 in “Journal of cosmetic dermatology” The synthetic retinoid EC23 thickens skin and promotes hair growth more effectively and with a lower dose than natural retinoids.
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April 2019 in “iScience” EGFR helps control how hair grows and forms without needing p53 protein.
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June 2023 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Vitamin D helps skin stem cells heal wounds by working with a key skin protein.
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July 2019 in “Stem Cell Research & Therapy” Epidermal stem cells help heal severe skin wounds and have potential for medical treatments.
105 citations,
October 2017 in “Stem cells” Wnt signaling is crucial for skin development and hair growth.
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November 2017 in “Journal of developmental biology” The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.
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July 2020 in “World journal of stem cells” Vitamin D and calcium are important for skin stem cell function and wound healing.
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August 2009 in “Differentiation” Desmoglein 4 is controlled by specific proteins that affect hair growth.
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January 2012 in “Elsevier eBooks” The document concludes that the skin is a complex organ providing protection, sensation, and healing, with challenges in treating conditions like itchiness.
April 2018 in “Journal of Investigative Dermatology” The human skin's outer layer has more variety in cell types and development paths than previously thought.
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April 2000 in “Gene” Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.
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February 1996 in “Journal of biological chemistry/The Journal of biological chemistry” The TGM3 gene's promoter region is key for skin and hair cell function and may aid gene therapy.
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February 2012 in “Cell Cycle” MicroRNAs are crucial for controlling skin development and healing by regulating genes.