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This review discusses how inflammation influences hair follicle stem cell activities like wound healing and follicle cycling and suggests a potential link between inflammation, stem cell activation, and programmed cell death.

This study examines the role of hair follicle stem cells in epidermal regeneration during skin soft tissue expansion, proposing a potential method for their cellular and molecular regulation.

This study suggests that a novel micropatterned dermal–epidermal matrix (μDERM) enhances keratinocyte function and epidermal morphology, offering potential improvements in skin substitute design for wound healing applications.

This study reports that transplantation of an ESCs-collagen-chitin biomimetic membrane leads to successful in situ skin regeneration, including hair follicle cell proliferation and formation of dermatoglyphs, in nude mice with full-thickness skin defects.

In this study, researchers observed that the epidermal specializations on the tail scales of Lygodactylus lizards, including sensory organs and specific secretory glands, are fully restored with similar structure and distribution on regenerated tails.

This study found that follicular stem cells in hair follicles are more sensitive to the antiproliferative effects of glucocorticoids compared to basal keratinocytes due to incomplete desensitization.

This review discusses vitamin D and calcium signaling roles in epidermal stem cell processes essential for wound healing but reports no new experimental results, emphasizing their potential interdependent regulatory mechanisms.

This study found that quiescent bulge stem cells, when prevented from contributing to hair follicle and epidermal regeneration, did not affect hair follicle growth or wound healing in the short term.

This study found that CD26+ fibroblasts are crucial for effective extracellular matrix production and achieving rapid epidermal and dermal homeostasis in human tissue-engineered skin substitutes transplanted onto rodents.

In this mouse study, researchers reported that sequential monopolar-bipolar radiofrequency irradiation significantly improved skin quality by increasing collagen density, elastin fiber expression, and fibroblast differentiation more than monopolar RF treatment alone.

This study found that epidermal stem cells in live mice exhibit coordinated intercellular Ca 2+ signaling governed by G2 cycling stem cells and mediated by Connexin43, essential for tissue-wide communication during regeneration.

This review highlights emerging evidence that biophysical and metabolic cues, such as oxygen levels and tissue mechanics, significantly influence skin stem cell behavior, which is crucial for developing advanced wound healing therapies beyond traditional infection and inflammation control.

This study indicates that the protein Bcl-2 has a dual role, protecting hair follicle stem cells from apoptosis during regeneration and promoting tumor formation under oncogenic stress.

This study reported that apremilast treatment did not lead to sustained improvement in SALT scores for most patients with extensive and treatment-resistant alopecia areata.

This study found that transgenic mice with expression of HPV16 E6/E7 oncogenes showed improved ear tissue regeneration, including hair follicles and cartilage, without tumor formation.

This study found that engineered reconstituted skin can form morphogenetic units that promote tissue patterning and hair regeneration, with certain signaling pathways restoring this ability in adult and fetal cells.

This study found that activating Wnt/beta-catenin signaling in hair follicles is sufficient to induce adipocyte generation in the dermis, affecting both hair follicle stem cell activation and adipocyte differentiation.

This study found that large excisional wounds in rats across seven strains do not regenerate new hair follicles, unlike in mice, possibly due to differences in epidermal competence and transcriptional profiles.

Wnt signaling helps regenerate hair follicles in wounds by reducing skin cell sensitivity to mechanical stress.

This study found that injecting a mixture of epidermal stem cells and dermal papilla cells can induce hair follicle regeneration and well-ordered epidermis formation in mice.

This review discusses current experimental approaches for regenerating human hair follicles using tissue engineering and isolated cells, but reports no successful strategies with adult cells yet found.

This review discusses the regeneration capabilities of various vertebrate tissues, focusing on the unique ability of certain species to regenerate teeth and lens, and reports no new results.

This review discusses the biological features and clinical applications of epidermal stem cells in wound healing and tissue regeneration, emphasizing the need for further understanding of their mechanisms.

This study found that hair follicle and interfollicular epidermis stem cells contribute differently to skin regeneration, with their persistence influenced by factors like spatial constraints and competition moderated by Notch suppression.

This study found that adding epidermal growth factor to mesenchymal stem cells enhanced wound healing and hair follicle regeneration in rats compared to stem cells alone.

In this study, researchers observed that exposure to low-frequency electromagnetic fields enhanced hair follicle regeneration and formation of hair follicle-like structures in bioengineered skin in nude mice.

In this study, murine fetal epidermal stem cells successfully formed new hair follicle structures when cografted with folliculus pili cells in nude mice.

This study found that epidermal growth factor promotes hair cell regeneration in young chickens damaged by gentamicin, accelerating recovery to normal basilar papilla structure.

This study demonstrates that Wnt signaling plays a crucial mechanoregulatory role in skin regeneration by influencing cellular responses to substrate rigidity, which promotes hair follicle regeneration in the wound-induced hair neogenesis model.

This study found that STAT5 activation and Sox18 are key in regulating hair follicle induction and cycling, while transducing SKPs with active STAT5B improved wound healing by reducing inflammation.