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Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

Topical L-thyroxine may help with wound healing and hair growth but should be used short-term due to potential risks.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Early treatment and lifestyle changes are important for managing PCOS in young people to prevent long-term health issues.

Testosterone therapy can improve sexual desire and function in postmenopausal women but should be used cautiously and not based solely on testosterone levels.

We need better ways to test and understand SARMs to make safer and more effective treatments.

The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

The document concludes that accurate diagnosis of male and female gonadal disorders is crucial for effective treatment and better patient outcomes.

Insulin resistance is linked to PCOS and can lead to other health issues, but treatments like metformin can help manage symptoms.

Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.

Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.

Puberty often causes skin issues like acne and excessive sweating, and treatments require patience as results may vary.

Changing protein kinase levels in pituitary cells affects calcium flow and beta-endorphin release.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

Hormonal therapies are safe and effective for treating acne in female adolescents, with specific treatments for those with endocrine disorders.

Understanding how androgens work is key for creating new treatments for prostate issues and hair/skin conditions.

Glucocorticoids are powerful anti-inflammatory drugs that must be used carefully to avoid serious side effects.

Flutamide combined with an LHRH agonist effectively inhibits prostate growth, suggesting it could treat prostate cancer.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

PCOS may start before birth, involves metabolic issues, and can be treated with drugs like metformin and lifestyle changes.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

Melatonin protects skin against UV damage by regulating various cellular processes.

DHEA may help with sexual function when used intravaginally by menopausal women but is similar to hormone therapy in other aspects and might cause more side effects like acne and hair loss.

Male pattern baldness may be caused by factors like poor blood circulation, scalp tension, stress, and hormonal imbalances, but the exact causes are still unclear.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Neurosteroids help regulate oxytocin levels, especially during stress and pregnancy, to protect against premature labor.