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High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

Hormones significantly affect hair and oil gland function in the skin, and more research is needed on skin-related hormone disorders.

Finasteride can cause lasting sexual, emotional, and cognitive issues, with varying severity.

Environmental factors, hormones, nutrition, and stress all significantly affect skin health and aging.

The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Androgens play a role in female sexual function, and testosterone therapy can help women with low sexual desire, but more research is needed on treatments and long-term safety.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.

The conclusion is that the best initial treatment for hirsutism is usually oral contraceptives, with the addition of antiandrogens or insulin sensitizers if needed, and topical eflornithine or laser treatments as supplementary options.

Human hair follicles can make and process prostaglandins, which may affect hair growth.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

Excessive hair growth in women often has no known cause and is not linked to race or other hormonal symptoms.

Glutamine metabolism affects hair stem cell maintenance and their ability to change back to stem cells.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Male genital development is driven by androgen signaling and understanding it could help address congenital anomalies.

The conclusion is that hirsutism should be diagnosed and treated because it affects quality of life and may signal other health problems.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Existing drug dexamethasone may lower death risk in severe COVID-19 cases; more research needed for other drugs.

Low testosterone and 5α-reductase inhibitors can harm men's metabolic and sexual health; testosterone therapy may help, but discussing 5α-RIs' side effects is important.

Melatonin protects skin against UV damage by regulating various cellular processes.

Oral retinoids are effective for treating severe skin disorders but have reversible side effects and risks for pregnant women.

Certain HSD3B1 gene types are linked to worse prostate cancer outcomes and affect treatment response and other health conditions.