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Hormones affect skin aging, and treatments targeting hormonal balance may improve skin health.

Flutamide caused damage to male rat reproductive organs and may affect fertility.

Obesity is linked to many gastrointestinal diseases and needs more research for treatment development.

PCOS increases the risk of heart disease and type 2 diabetes in women.

Aldactone effectively reduces hair thickness in women with excessive hair growth, both alone and with other treatments.

Spironolactone effectively makes hair shafts thinner in women with excessive hair growth.

Older men with lower levels of available testosterone are more likely to be frail.

Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.

Polycystic ovary syndrome is a complex condition that affects women's mental, reproductive, and metabolic health throughout their lives.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

Hidradenitis suppurativa, a chronic skin disease, can be managed with antibiotics, lifestyle changes, and in severe cases, surgery. Early diagnosis and careful planning are key, and laser treatment can be an efficient solution for mild to severe cases.

Minoxidil and finasteride treat hair loss in men, while minoxidil treats hair loss in women.

Androgens can both increase and decrease hair growth in different parts of the body.

Flutamide is more effective and has fewer side effects than spironolactone for treating hirsutism.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Vitamin D is important for skin health and may affect conditions like psoriasis and hair loss, but more research is needed to understand its role fully.

Periodontal ligament stem cells show promise for regrowing tissues but require more research for safe, effective use.

Insulin sensitizers may slightly reduce hirsutism but are less effective than other treatments.

Pregnancy can cause skin pigmentation, stretch marks, and changes in hair, nails, and sweat glands, with most resolving after birth.

Finasteride treats enlarged prostate, shrinks it, improves urination, but may cause sexual dysfunction and isn't for women or children.

Some common medications can harm male fertility, but many effects can be reversed.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

Women with PCOS often feel stigmatized and have mood issues, which can lower their sexual satisfaction, but proper treatment and support can help.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Finasteride reduces Hidradenitis Suppurativa flare-ups in children and teens, but long-term safety is unknown.

SHBG may be a useful early indicator and treatment target for PCOS.

Prostaglandin D₂ might be targeted for new male pattern baldness treatments.

The document suggests treating individuals with nonclassic congenital adrenal hyperplasia who show symptoms, especially those related to excess male hormones.

5α-reductase inhibitors and alpha-1 adrenergic antagonists together effectively treat benign prostatic hyperplasia, with long-term benefits.