124 citations
,
March 2012 in “JAMA” This abstract discusses the unclear role of dihydrotestosterone (DHT) in postembryonic life in marsupials and possibly humans, reporting no new findings.
58 citations
,
September 2012 in “Dermatologic Clinics” This article reviews current knowledge on the causes, diagnosis, and medical treatments for androgenetic alopecia, particularly in men, and reports no new findings.
50 citations
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March 2017 in “PeerJ” This study found that longer exposure to 5α-reductase inhibitors significantly increased the risk of persistent erectile dysfunction, especially in younger men exposed to finasteride.
28 citations
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January 1991 in “Reproductive Toxicology” Finasteride temporarily lowers male rat fertility without affecting libido.
23 citations
,
June 1999 in “Clinical Therapeutics” In this study, finasteride was found to reduce costs associated with benign prostatic hyperplasia compared to watchful waiting and terazosin, especially in men with higher prostate-specific antigen levels.
21 citations
,
January 2020 in “General and Comparative Endocrinology” This review examines the diverse roles of SRD5α enzymes across species, focusing on their involvement in steroid synthesis, sexual development, and various physiological processes, but reports no new clinical results.
21 citations
,
August 1994 in “Clinical endocrinology” This article reviews the effects of 5 alpha-reductase inhibitors for treating conditions like male pattern baldness and benign prostatic hyperplasia, noting significant DHT reduction but reports no new clinical results.
19 citations
,
April 2020 in “Dermatologic Therapy” This review found that dutasteride is more potent than finasteride as a dual receptor dihydrotestosterone blocker for treating androgenetic alopecia and shares a similar safety profile in terms of fertility, teratogenicity, neurotoxicity, and hepatotoxicity.
18 citations
,
March 2020 in “Frontiers in Neuroendocrinology” This study suggests that synthetic steroid analogues or 5α-reductase modulation could be potential therapeutic strategies for nervous system disorders, but further research on their effects is necessary.
15 citations
,
July 2016 in “Urologic Clinics of North America” This study found that combining 5-alpha reductase inhibitors with alpha-blockers provided the best symptomatic relief and reduced the risk of clinical progression for BPH, while PDE5 inhibitors could offset sexual side effects.
11 citations
,
January 2018 in “Asian Journal of Andrology” Researchers observed that dutasteride and finasteride caused structural changes in the penises of both control and hypertensive rats, with dutasteride having a more pronounced effect on the corpus cavernosum.
10 citations
,
May 2018 in “Neuropharmacology” This study suggests that inhibitors of steroidogenic enzymes may have therapeutic potential for certain behavioral disorders linked to dopaminergic hyperfunction, despite concerns about their endocrine impacts.
10 citations
,
June 2010 in “Expert Opinion on Drug Metabolism & Toxicology” This review discusses the development and trials of finasteride for prostate cancer prevention, reporting reduced cancer prevalence but noting concerns about increased high-grade cancer incidence.
8 citations
,
July 2020 in “International Journal of Pharmaceutics” In this study, complexation with cyclodextrins was reported to increase the solubility of FIN for potential use in aqueous formulations for treating male androgenic alopecia.
4 citations
,
May 2019 in “Physiology & Behavior” This study found that cocaine disrupted the relationship between certain brain androgen levels and sexual behavior in male rats, with dose-dependent effects on testosterone metabolism.
This study reported that autologous platelet-rich plasma injections significantly improved stress urinary incontinence symptoms in women without affecting sexual function, suggesting it as a promising minimally invasive treatment option.
In this study, women with stress urinary incontinence who received a platelet-rich plasma injection experienced significant improvement in symptoms without significant adverse reactions.
In this interventional study, researchers observed that women with stress urinary incontinence experienced significant symptom improvement one and three months after receiving autologous platelet-rich plasma injections, with no notable impact on sexual function or adverse reactions reported.
2 citations
,
March 2018 in “Current Opinion in Urology” This review discusses the clinical applications and adverse effects of 5-alpha reductase inhibitors for treating benign prostatic hyperplasia and androgenic alopecia, noting controversies around their implications for other diseases, without reporting new results.
This study reported that women with stress urinary incontinence experienced significant symptom improvement at one and three months following autologous platelet-rich plasma injections, highlighting this minimally invasive treatment as effective and safe.
July 2026 in “International Journal of Drug Delivery Technology” This study found that a combination of curcumin and piperine demonstrated moderate antioxidant activity, negligible cytotoxicity, and significant potential for promoting hair regrowth in rat models of alopecia, suggesting it could be a safe and effective natural alternative for managing hair loss.
September 2025 in “International Journal of Innovative Technologies in Social Science” This review found that dutasteride is more effective than finasteride in increasing hair count and shaft thickness for androgenetic alopecia in men, with potential for reduced systemic side effects through mesotherapy, although further research is needed on long-term safety and dosage.
April 2017 in “Austin Journal of Cancer and Clinical Research” This article reviews the role and controversies of 5α-reductase inhibitors like finasteride and dutasteride in managing prostate cancer, without presenting new research results.
January 2016 in “Archivio italiano di urologia, andrologia” This article reviews treatment-induced sexual dysfunctions related to 5-alpha-reductase inhibitors and reports no new results; it highlights the need to better define and understand this controversial topic.
8 citations
,
September 2010 in “Journal of Men's Health” This article reviews the pathophysiology, diagnosis, and treatment of androgenic alopecia but reports no new clinical findings.
1 citations
,
January 2017 in “Expert opinion on orphan drugs” This study reviews current systemic treatments for hidradenitis suppurativa, highlighting traditional methods and new options like biological agents, and suggests that pharmacological therapies show promise, particularly for non-advanced cases, despite the disease's complex etiology involving factors such as genetics and inflammation.
March 2025 in “HAL (Le Centre pour la Communication Scientifique Directe)” This thesis investigates the underlying mechanisms and treatment options for androgenetic alopecia, highlighting the molecular roles of androgens and genetic predispositions, and evaluates current and emerging therapies, such as PROTACs and Janus Kinase inhibitors, to enhance patient management.
February 2026 in “Journal of Psychosexual Health” This case report describes a 26-year-old man who experienced persistent sexual dysfunction and other symptoms for 19 months after stopping finasteride for androgenetic alopecia. The authors highlight post-finasteride syndrome's impact on quality of life and stress the need for careful risk-benefit assessment before prescribing.
4 citations
,
October 2023 in “Fertility and Sterility” This review highlights potential negative impacts of certain medications on male fertility, such as hormonal disruption and germ cell toxicity, emphasizing the importance of clinicians being aware of these effects to advise on safer alternatives.
August 2024 in “The Journal of Urology” This study updates guidelines for evaluating and managing male infertility, including revised testing recommendations for Y-chromosome microdeletions, use of pelvic MRI, and testicular sperm in nonazoospermic males.