11 citations
,
January 2018 in “Asian Journal of Andrology” Researchers observed that dutasteride and finasteride caused structural changes in the penises of both control and hypertensive rats, with dutasteride having a more pronounced effect on the corpus cavernosum.
December 2016 in “The Journal of Sexual Medicine” This study reviewed the preferences and reasons for testosterone injection therapy among 53 Canadian men with hypogonadism, finding that most opted for injections due to efficacy, ease, and cost considerations.
21 citations
,
August 2016 in “Translational Andrology and Urology” This review discusses the pathophysiology of delayed ejaculation, highlighting the role of various biogenic and psychogenic factors, but reports no new clinical findings.
October 2015 in “Elsevier eBooks” Finasteride helps hair growth and prostate issues but may cause sexual side effects and increase tumor risk.
223 citations
,
December 2010 in “The Journal of Sexual Medicine” This review discusses persistent adverse effects of 5α‐reductase inhibitors, like diminished libido and erectile dysfunction, in some patients and highlights the need for patient discussions before therapy, especially for androgenetic alopecia.
75 citations
,
January 2014 in “Korean Journal of Urology” This review discusses the adverse effects of 5α-reductase inhibitors, finasteride and dutasteride, on sexual, psychological, and vascular health, emphasizing the need for physicians to inform patients of these risks.
2 citations
,
April 2017 in “European Urology” Using finasteride for hair loss or prostate issues does not significantly raise the risk of erectile dysfunction.
March 2024 in “Cleveland Clinic journal of medicine” This review details contemporary medical management options for benign prostatic hyperplasia, highlighting the expanding role of phosphodiesterase-5 inhibitors and beta-3 agonists, but reports no new clinical findings.
January 2018 in “Sohag Medical Journal” Combining topical dutasteride with microneedling is more effective for hair growth than microneedling alone.
15 citations
,
January 2018 in “Acta dermato-venereologica” This meta-analysis found that treating male androgenetic alopecia with 5α-reductase inhibitors increases the risk of sexual dysfunction, with a statistically significant risk for finasteride but not for dutasteride.
81 citations
,
June 2014 in “American Journal of Men's Health” This study highlights that adverse effects from finasteride may persist in men after discontinuation, indicating a potential "post-finasteride syndrome.
47 citations
,
September 2013 in “Aaps Pharmscitech” This study found that liquid crystalline nanoparticles formulated with Cremophor surfactants significantly enhanced skin permeation of finasteride compared to lower surfactant concentrations.
7 citations
,
October 2009 in “Journal of the American Geriatrics Society” This study found that finasteride may reduce inappropriate sexual behaviors in geriatric patients with vascular dementia and benign prostate hyperplasia without serious side effects, though some patients required additional medications.
6 citations
,
May 2011 in “Pharmacognosy Journal” This review discusses the causes of alopecia, including androgenetic alopecia, and potential active ingredients for hair regrowth, but it does not report new clinical results.
4 citations
,
April 2018 in “British Journal of Dermatology” Finasteride for female hair loss has low side effects, more research needed.
1 citations
,
December 2010 in “Elsevier eBooks” This review covers cell transplantation methods for genitourinary reconstruction, discussing tissue sources and complications but presenting no new clinical findings.
November 2023 in “Magna Scientia Advanced Research and Reviews” The researchers proposed that an epigenetic change in brain androgen receptors caused by finasteride could lead to post finasteride syndrome, while trazodone might reverse this effect by altering the epigenetic expression related to erection and libido.
October 2023 in “Bangladesh journal of urology” This study in Bangladesh reports that 81% of patients with refractory idiopathic hematospermia showed remission after three months of finasteride treatment, significantly higher than the 27% remission rate in the placebo group, with results sustained for some time after stopping the medication.
October 2017 in “Springer eBooks” A thorough initial check-up is essential before sperm banking to ensure the best chance of preserving good quality sperm.
Treatments for hair loss vary, but cell-based options may be the future.
225 citations
,
July 2007 in “The Journal of Sexual Medicine” In this study, patients informed about finasteride's potential sexual side effects reported a significantly higher occurrence of these side effects, suggesting a nocebo effect.
21 citations
,
January 2020 in “General and Comparative Endocrinology” This review examines the diverse roles of SRD5α enzymes across species, focusing on their involvement in steroid synthesis, sexual development, and various physiological processes, but reports no new clinical results.
15 citations
,
July 2016 in “Urologic Clinics of North America” This study found that combining 5-alpha reductase inhibitors with alpha-blockers provided the best symptomatic relief and reduced the risk of clinical progression for BPH, while PDE5 inhibitors could offset sexual side effects.
8 citations
,
July 2018 in “Current Sexual Health Reports” This review discusses post-finasteride syndrome, emphasizing its serious psychological and cognitive symptoms and the need for more research and awareness in the medical community, but provides no new clinical findings.
3 citations
,
December 2016 in “Sexual medicine reviews” This review discusses methods for improving study design and evaluation in sexual health literature and reports no new clinical results; it highlights current methodological issues and the benefits of validated questionnaires.
January 2020 in “Archives of urology” This review discusses concerns about persistent side effects of finasteride, such as sexual dysfunction and suicidal ideation, urging the medical community to recognize and address these issues.
1040 citations
,
October 1992 in “The New England Journal of Medicine” In this study, 5 mg of finasteride per day significantly improved urinary symptoms and reduced prostate volume in men with benign prostatic hyperplasia, but increased the risk of sexual dysfunction.
137 citations
,
March 2006 in “Cns Drug Reviews” This review explores finasteride's effects on neuroactive steroid levels and their potential influence on disorders like depression and alcohol withdrawal but reports no new clinical findings.
124 citations
,
March 2012 in “JAMA” This abstract discusses the unclear role of dihydrotestosterone (DHT) in postembryonic life in marsupials and possibly humans, reporting no new findings.
98 citations
,
August 2004 in “BJU international” This review critically examines the current medical management strategies for BPH/LUTS and reports no new experimental results.