115 citations
,
September 2000 in “The Lancet” Early hair loss may indicate risk of insulin resistance.
72 citations
,
January 2007 in “Dermatology” This study found a correlation between moderate to extensive alopecia and low-grade inflammation, a cardiovascular risk marker, particularly in young men under 35 with central obesity.
61 citations
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March 2009 in “The Journal of the American Board of Family Medicine” This article reviews current diagnostic and treatment approaches for discoid lupus erythematosus, emphasizing the importance of early treatment and photoprotection, but reports no new clinical findings.
57 citations
,
September 2016 in “Arthritis Care & Research” This study found that people with systemic lupus erythematosus consulted primary care more frequently and with specific clinical features before diagnosis, and it developed a risk prediction model that may help in identifying at-risk individuals.
56 citations
,
June 2001 in “European journal of cardiovascular prevention & rehabilitation” This study found that men with early-onset androgenic alopecia have a higher risk of needing coronary revascularization before age 60 compared to those with later onset or no hair loss.
54 citations
,
March 2012 in “International Journal of Andrology” This study found that prenatal exposure to certain pesticides may lead to earlier breast development in girls, potentially associated with higher androgen levels.
53 citations
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August 2019 in “American journal of human genetics” This study found that FOXN1 haploinsufficiency is a significant genetic factor causing T cell lymphopenia at birth, linked to reduced thymic function in both humans and mice.
53 citations
,
April 2016 in “Stem cell research & therapy” This study reports that LL-37 treatment enhances cell proliferation, migration, and secretion of regenerative factors in adipose-derived stem cells, potentially promoting hair growth in vivo.
41 citations
,
February 2021 in “Cureus” This study found that in males with mild COVID-19, treatment with dutasteride, along with standard therapy, may reduce viral shedding and inflammation compared to placebo.
29 citations
,
February 2019 in “Environment international” This study found that higher prenatal and early childhood lead exposure may be associated with delayed pubertal development in girls, but not in boys, in Mexico City.
24 citations
,
May 2017 in “Annals of botany” This study found that root hair growth in Arabidopsis thaliana is stimulated by pathogenic Pseudomonas strains similarly to beneficial rhizobacteria, relying on ethylene signaling and an efficient exocyst-dependent secretory process.
23 citations
,
March 2017 in “JAAD case reports” This study reports a new family with hereditary fibrosing poikiloderma (POIKTMP) and identifies a pancreatic cancer occurrence in a family member, raising questions about FAM111B's role as a potential cancer predisposition gene.
22 citations
,
June 2013 in “Australasian Journal of Dermatology” Early stage bald spots are linked to skin inflammation and damage to the upper part of the hair follicle.
21 citations
,
March 2013 in “Cancer Epidemiology, Biomarkers & Prevention” This study found that early-onset baldness in African-American men is associated with an increased risk of developing prostate cancer and more aggressive tumors, with potential interactions involving age and smoking.
19 citations
,
January 2013 in “Annals of Dermatology” In this study, oral steroid pulse therapy was found to be as effective and well-tolerated as intravenous pulse therapy in treating severe alopecia areata, especially when started within one year of disease onset.
18 citations
,
October 2019 in “European Journal of Dermatology” This article reviews treatment options for pityriasis rubra pilaris but reports no new clinical findings, often noting treatments as unsuccessful.
16 citations
,
November 2020 in “Research Square (Research Square)” In this study, early treatment with nitazoxanide, ivermectin, or hydroxychloroquine, combined with azithromycin, was associated with reduced hospitalizations, respiratory complications, and deaths in early-stage COVID-19 patients compared to untreated controls.
13 citations
,
November 2019 in “Scientific reports” This study found that inhibiting 5α-reductase in molluscs provokes a specific shell morphology, suggesting gastropods might have unique 5α-reductase substrates absent in vertebrates.
13 citations
,
December 2016 in “Journal of Cosmetic Dermatology” This study found increased oxidative stress in younger male patients with early-onset androgenetic alopecia compared to healthy peers, suggesting a potential role for antioxidants in their treatment.
13 citations
,
December 2005 in “Dermatologic surgery” In this study, Er:YAG laser therapy initially improved the appearance of eruptive vellus hair cysts but was ultimately ineffective due to early recurrence and concerns about atrophy or scarring.
12 citations
,
September 2020 in “Stem cell research & therapy” This study concluded that early-stage tissue-engineered skin substitutes, developed using skin progenitor cells, had a better graft efficiency and supported hair follicle formation, which may improve wound healing outcomes.
11 citations
,
November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study observed that early treatment with azithromycin and either nitazoxanide, ivermectin, or hydroxychloroquine in COVID-19 patients may reduce viral shedding, symptom duration, and respiratory complications compared to untreated patients.
11 citations
,
March 2018 in “Protoplasma” In this laboratory study, procyanidin B2 inhibited early plant growth and biochemical responses in wheat seedlings treated with lipopolysaccharides from Azospirillum brasilense, suggesting that plant response activation requires LPS recognition by plant cells.
11 citations
,
December 2017 in “Diabetes Therapy” This study highlights the need to prioritize early prevention of type 2 diabetes mellitus by focusing on early pathophysiologic mechanisms such as insulin resistance, rather than hyperglycemia, as conditions like non-alcoholic fatty liver disease and polycystic ovarian syndrome are early indicators of future diabetes risk.
10 citations
,
January 2019 in “Indian Journal of Dermatology” This study found that male patients with early-onset androgenetic alopecia were associated with metabolic syndrome, but not insulin resistance, compared to age-matched controls.
8 citations
,
February 2020 in “Aesthetic Surgery Journal” This study found that early male hair loss treatment with Puregraft fat and low-dose adipose-derived regenerative cells increased terminal hair counts at 24 weeks compared to a saline control, indicating promise for androgenetic alopecia treatment.
8 citations
,
August 2013 in “PubMed” In this study, early onset androgenic alopecia in Thai men was associated with metabolic syndrome, suggesting that early detection of metabolic syndrome in these individuals may help prevent cardiovascular diseases.
7 citations
,
December 2021 in “Journal of The American Academy of Dermatology” This article discusses early-onset telogen effluvium following COVID-19 infection and reports no new results, encouraging further exploration into its pathogenesis and differences compared to other acute forms.
7 citations
,
November 2006 in “Pediatric Dermatology” This article describes the first reported case of alopecia in a neonate with congenital syphilis.
6 citations
,
March 2020 in “Journal of International Medical Research” This study reported that early-onset androgenetic alopecia primarily affects Chinese males aged 21–30, with a high likelihood of paternal inheritance.