79 citations
,
January 2015 in “Journal of Materials Chemistry B” This review discusses the development and future prospects of biomaterials for in situ tissue regeneration but reports no new research results; it underscores the importance of biomaterials in addressing tissue defects.
78 citations
,
October 2020 in “Experimental Dermatology” This review summarizes 15 years of clinical and experimental research advancements in hidradenitis suppurativa, highlighting its recognition as a uniquely healable inflammatory skin disease but reports no new clinical results.
76 citations
,
August 2018 in “International Journal of Cosmetic Science” This review discusses the use of Dermal Papilla cells as in vitro models for studying hair growth modulators, emphasizing their role in aiding the development of new hair treatments, but reports no new clinical results.
73 citations
,
September 2016 in “Journal of Translational Medicine” This review discusses the drug repurposing of cardiovascular medications like aspirin and statins for new uses, including potential anti-tumor effects, noting promising experimental outcomes but less conclusive clinical trials, particularly in the field of cancer treatment.
70 citations
,
August 2020 in “Nanomaterials” This review discusses the development of electrospun nanofibrous scaffolds for promoting angiogenesis in tissue engineering but notes that their clinical application beyond bone and skin repair is still limited.
60 citations
,
November 2020 in “International Journal of Medical Sciences” This review highlights the potential of near-infrared light therapy to improve metabolic, antioxidant, and cognitive functions without adverse effects, and supports its use for visual and neurological conditions through molecular and cellular mechanisms, as reported in this source.
60 citations
,
May 2011 in “Endocrinology and Metabolism Clinics of North America” This article discusses the association between hypertension and polycystic ovary syndrome, highlighting the need for managing related risk factors, but reports no new clinical results.
59 citations
,
October 2020 in “Stem Cell Reviews and Reports” This review discusses potential mechanisms contributing to higher COVID-19 mortality among men, particularly the roles of smoking, genetic factors, and reproductive hormones, without presenting new clinical findings.
54 citations
,
July 2017 in “Scientific Reports” This study found that the JMJD3/NF-κB-Notch1 pathway plays a crucial role in regulating keratinocyte migration and skin wound healing, with Notch1 affecting key genes involved in cell migration.
53 citations
,
April 2018 in “Journal of The American Academy of Dermatology” This article reviews therapy-related hair disorders in oncology patients, detailing underlying mechanisms and potential management strategies, but reports no new clinical findings.
52 citations
,
October 2016 in “Clinics in Dermatology” This review discusses various drugs that can cause drug-induced acne, noting specific clinical and histopathologic features, but reports no new clinical findings.
47 citations
,
December 2020 in “Journal of the European Academy of Dermatology and Venereology” This article reviews the classification, diagnosis, and management of hair disorders, emphasizing the role of trichoscopy and early diagnosis for effective treatment but reports no new clinical findings.
46 citations
,
February 2016 in “Experimental Dermatology” This review discusses the genetic research developments in androgenetic alopecia, reporting no new clinical results, and highlights the potential for discovering novel therapeutic targets.
43 citations
,
July 2019 in “Stem Cells International” This review discusses advances and challenges in skin tissue engineering, focusing on developing 3D constructs for functional skin substitutes, and reports no new clinical results.
41 citations
,
July 2015 in “Current Drug Discovery Technologies” This review discusses various plants and herbal formulations traditionally used for hair growth and notes their potential as safer alternatives to synthetic hair loss treatments, but reports no new clinical results.
38 citations
,
January 2023 in “International Journal of Medical Sciences” This review discusses the potential of repeated low-level red-light therapy to inhibit myopia progression through metabolic effects, highlighting its molecular and cellular impact, but reports no new clinical results.
36 citations
,
May 2021 in “Nutrients” This review summarizes current knowledge on the efficacy of natural molecule supplementation, such as inositols and omega-3 fatty acids, in managing PCOS symptoms but reports no new clinical results.
34 citations
,
July 2020 in “Frontiers in immunology” This mini-review discusses the role of androgens, specifically testosterone and dihydrotestosterone, in the pathogenesis of autoimmune liver diseases and reports no new results.
34 citations
,
February 2016 in “Fertility and Sterility” This study suggests that higher PDCD4 expression may play a significant role in polycystic ovary syndrome pathogenesis through its association with obesity, insulin resistance, lipid metabolism disorders, and increased granulosa cell apoptosis.
33 citations
,
September 2017 in “Molecules” This study found that red ginseng oil and its major components improved hair regrowth in testosterone-treated mice by promoting an earlier anagen phase and altering related gene expressions.
32 citations
,
February 2017 in “Human Reproduction” This study found that women with PCOS were more likely to have longer anogenital distances, indicating possible intrauterine origins linked to prenatal androgen exposure.
31 citations
,
May 2019 in “Nature communications” This study found that Blimp1+ cells from mice can generate sebaceous gland organoids in vitro, which mimic natural gland traits and may aid in studying acne vulgaris.
31 citations
,
September 2016 in “PLoS ONE” The researchers reported that in hairless mice, epidermal cell division orientations and epidermal thickness varied by body site, with dorsal and ear epidermis primarily dividing parallel to the basement membrane, unlike hind paw and tail epidermis.
30 citations
,
July 2018 in “Scientific Reports” In this study, a high-fat, high-cholesterol diet in atherosclerotic mice led to skin inflammation and hair problems, which could be reversed by inhibiting glycosphingolipid synthesis.
30 citations
,
January 2009 in “Nuclear Receptor Signaling” This study identified the Hairless (Hr) gene-encoded protein as a corepressor that plays a crucial role in maintaining skin and hair by regulating epithelial stem cell differentiation and gene expression via chromatin remodeling, which may impact both development and disease.
28 citations
,
September 2013 in “Expert Opinion on Therapeutic Patents” This review discusses various resveratrol derivative patents for therapeutic, nutraceutical, and cosmetic use, but reports no clinical results and notes that claims of improved efficacy lack trial evidence.
27 citations
,
March 2024 in “Frontiers in Pharmacology” This review highlights the potential of natural product-derived compounds, such as flavonoids and alkaloids, to reverse multidrug resistance in tumors, emphasizing their role in regulating signaling pathways, proteins, and genes related to MDR, and aims to guide future research efforts in this area.
26 citations
,
October 2017 in “Clinical Reviews in Allergy & Immunology” This review explores skin manifestations associated with autoimmune liver diseases and highlights known and probable links, such as vitiligo's strong association with autoimmune hepatitis.
25 citations
,
July 2021 in “Journal of Medical Virology” This review focuses on the various skin symptoms associated with COVID-19 but reports no new clinical findings.
25 citations
,
July 2017 in “Archives of Dermatological Research” This review summarizes preclinical and clinical information on herbal products for hair loss treatment, highlighting their mechanisms, follicular penetration, and potential side effects, suggesting they may offer alternatives to synthetic drugs with fewer side effects.