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GlossaryDorsal Root Ganglia (DRG)

clusters of nerve cell bodies transmitting sensory information to the spinal cord

Dorsal Root Ganglia (DRG) are clusters of nerve cell bodies located along the spinal cord. They play a crucial role in transmitting sensory information from the peripheral nervous system to the central nervous system, including sensations like pain, temperature, and touch.

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ELife Assessment: Touch Receptor End-Organ Innervation and Function Require Sensory Neuron Expression of the Transcription Factor Meis2

research ELife Assessment: Touch Receptor End-Organ Innervation and Function Require Sensory Neuron Expression of the Transcription Factor Meis2

February 2024

Meis2 is essential for touch sensation and proper nerve connection to touch receptors in certain skin areas of mice.

Local Injection With Anti-Herpes Simplex Virus Antibodies Protects Against Development of Herpes Simplex Virus-Induced Sweating Disturbance

research Local Injection With Anti-Herpes Simplex Virus Antibodies Protects Against Development of Herpes Simplex Virus-Induced Sweating Disturbance

April 2023 in “Journal of Investigative Dermatology”

Injecting anti-herpes antibodies locally can prevent skin lesions and sweating problems caused by herpes simplex virus in mice.

research In Vitro Co-Culture Models of Merkel Cell-Neurite Complex in Touch Domes

October 2021 in “Journal of Investigative Dermatology”

The study concluded that the developed models are effective for studying hair growth mechanisms and testing new treatments.

Neuronal Plasticity of the Brain-Skin Connection: Stress-Triggered Up-Regulation of Neuropeptides in Dorsal Root Ganglia and Skin via Nerve Growth Factor-Dependent Pathways

research Neuronal Plasticity of the Brain-Skin Connection: Stress-Triggered Up-Regulation of Neuropeptides in Dorsal Root Ganglia and Skin via Nerve Growth Factor-Dependent Pathways

66 citations, July 2007 in “Journal of Molecular Medicine”

Stress increases certain chemicals in the skin and nerves, which might worsen skin conditions.

research Minoxidil Is a Potential Neuroprotective Drug for Paclitaxel-Induced Peripheral Neuropathy

28 citations, March 2017 in “Scientific Reports”

Minoxidil may protect nerves and improve hair quality during paclitaxel treatment.

American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1

research American Association of Clinical Endocrinologists, American College of Endocrinology, and Androgen Excess and PCOS Society Disease State Clinical Review: Guide to the Best Practices in the Evaluation and Treatment of Polycystic Ovary Syndrome - Part 1

343 citations, October 2015 in “Endocrine Practice”

The guide recommends specific methods for diagnosing PCOS and various treatments for its symptoms, while considering the health impacts on adolescents.

research TRPA1 Modulates Mechanotransduction in Cutaneous Sensory Neurons

286 citations, April 2009 in “The journal of neuroscience/The Journal of neuroscience”

TRPA1 is crucial for mechanical sensitivity in skin sensory neurons.

research Non-Edg Family LPA Receptors: The Cutting Edge of LPA Research

68 citations, July 2011 in “Journal of Biochemistry/The journal of biochemistry”

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.

Effect of Topical Application of Raspberry Ketone on Dermal Production of Insulin-Like Growth Factor-I in Mice and on Hair Growth and Skin Elasticity in Humans

research Effect of Topical Application of Raspberry Ketone on Dermal Production of Insulin-Like Growth Factor-I in Mice and on Hair Growth and Skin Elasticity in Humans

39 citations, August 2008 in “Growth hormone & IGF research”

Raspberry ketone may help grow hair and improve skin elasticity.

research Photobiomodulation: The Clinical Applications of Low-Level Light Therapy

33 citations, January 2021 in “Aesthetic Surgery Journal”

Low-Level Light Therapy (LLLT) is a safe and effective method for skin rejuvenation, acne treatment, wound healing, body contouring, and hair growth, but more well-designed trials are needed for confirmation.

research Dihydrotestosterone Inhibits Hair Growth in Mice by Inhibiting Insulin-Like Growth Factor-I Production in Dermal Papillae

32 citations, February 2024 in “Growth Hormone & IGF Research”

Dihydrotestosterone (DHT) stops hair growth in mice by lowering a growth factor important for hair.

research Dietary Isoflavone Increases Insulin-Like Growth Factor-I Production, Thereby Promoting Hair Growth in Mice

29 citations, March 2011 in “The Journal of Nutritional Biochemistry”

Eating isoflavone can help mice grow hair by increasing a growth factor.

research Hair Transplantation in Burn Scar Alopecia

8 citations, January 2015 in “Scars, burns & healing”

Hair transplantation effectively treats burn scar alopecia, improving self-esteem and confidence.

Dermatologist and Patient Perceptions of Treatment Success in Alopecia Areata and Evaluation of Clinical Outcome Assessments in Japan

research Dermatologist and Patient Perceptions of Treatment Success in Alopecia Areata and Evaluation of Clinical Outcome Assessments in Japan

7 citations, January 2021 in “Dermatology and therapy”

Both dermatologists and patients in Japan agree that treatment success for alopecia areata is having 20% or less scalp hair loss.

research LC-MS/MS Improves Screening Towards 21-Hydroxylase Deficiency

7 citations, December 2014 in “Gynecological Endocrinology”

LC-MS/MS is more reliable than immunoassays for diagnosing 21-hydroxylase deficiency.

research Megasessions

7 citations, August 2013 in “Facial Plastic Surgery Clinics of North America”

Megasessions in hair transplant can cover more area or increase density but need a skilled team and careful planning, and have both benefits like less downtime and risks like lower graft survival.

research The Role of Patients in Alopecia Areata Endpoint Development: Understanding Physical Signs and Symptoms

3 citations, October 2020 in “Journal of Investigative Dermatology Symposium Proceedings”

The main goal for new Alopecia Areata treatments should be significant improvement in scalp hair growth.

A Case of Systemic Mastocytosis: An Ultrastructural and Immunohistochemical Study of Dermal Mast Cells in Relation to Activation of the Epidermal Melanin Unit

research A Case of Systemic Mastocytosis: An Ultrastructural and Immunohistochemical Study of Dermal Mast Cells in Relation to Activation of the Epidermal Melanin Unit

2 citations, November 1998 in “Journal of The European Academy of Dermatology and Venereology”

Prednisone reduces organ mast cell infiltration but does not alter the abnormal appearance of mast cells in systemic mastocytosis.

research Combination Therapy for Male Cosmetic Patients

1 citations, November 2017 in “Dermatologic clinics”

Combination therapies can improve hair loss treatment results and boost self-confidence in men.

research Hair Restoration: A Sophisticated Art Form

1 citations, August 2013 in “Facial Plastic Surgery Clinics of North America”

Hair restoration has evolved into a refined art, providing happiness to patients and doctors.

research Follicle-Innervating Aδ-Low Threshold Mechanoreceptors Organize Through a Population-Dependent Mechanism

August 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Mouse touch-sensitive nerve cells adjust their connections based on competition with other similar cells.

Generation of Human Hair Follicle Organoids In Vitro and Ex Vivo by Co-Culture of Primary Human Hair Matrix Keratinocytes and Dermal Papilla Fibroblasts

research Generation of Human Hair Follicle Organoids In Vitro and Ex Vivo by Co-Culture of Primary Human Hair Matrix Keratinocytes and Dermal Papilla Fibroblasts

June 2020 in “Journal of Investigative Dermatology”

Scientists successfully grew mini hair follicles using human skin cells, which could help treat baldness.