1 citations
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October 2021 in “QJM: An International Journal of Medicine” This study found that platelet-rich plasma prepared using a double-spin method may be more effective for treating female pattern hair loss than single-spin PRP, although VEGF concentration was unaffected by either preparation method.
December 2023 in “PubMed” This study found that both single- and double-spin PRP preparation methods significantly increased thrombocyte counts and improved hair parameters in males with androgenetic alopecia, with the single-spin method showing a more significant increase in thrombocyte count.
January 2025 in “Journal of Bacha Khan Medical College.” This study compared two PRP preparation techniques for treating androgenetic alopecia and found that both methods led to some improvement in hair loss, but further research is suggested due to variations in PRP preparation.
10 citations
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September 2020 in “Archives of Dermatological Research” Both methods improve hair density and thickness; double-spin may be more effective.
July 2025 in “Frontiers in Medicine” In this systematic review and meta-analysis, the authors examined single-spin versus double-spin centrifugation protocols for PRP in patients with androgenic alopecia and found no significant difference in platelet concentration, hair density, or hair types between the protocols.
July 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” This study found no significant differences in platelet concentration or hair growth outcomes between single-spin and double-spin PRP centrifugation methods for treating androgenic alopecia, suggesting that the simpler single-spin approach may be preferable.
July 2025 in “OPAL (Open@LaTrobe) (La Trobe University)” In this systematic review and meta-analysis, the researchers found no significant difference in platelet concentration, hair density improvement, or changes in terminal and vellus hair rates between single-spin and double-spin PRP centrifugation protocols in treating androgenic alopecia.
October 2025 in “JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH” This study found that both single spin and double spin techniques of PRP preparation significantly improved hair growth in male androgenetic alopecia, with no statistical difference between the methods.
2 citations
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May 2024 in “Cureus” This study found that both single and double spin platelet-rich plasma methods significantly reduced chronic ulcer surface area, with single spin showing notable healing improvements.
July 2018 in “International Journal of Research in Medical Sciences” In this study, platelet-rich plasma treatment showed minimal effectiveness for Alopecia Areata but was more effective than no treatment, with a 20% improvement observed compared to 3.3% in the control group.
1 citations
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January 2017 in “Indian Dermatology Online Journal” This commentary reviews clinical trials on platelet-rich plasma treatments for androgenetic alopecia and emphasizes the need for standardized preparation methods and concentrations; it reports no new clinical results.
July 2023 in “International journal of trichology” This review concluded that the double-spin PRP preparation method may be more effective than the single-spin technique for treating androgenetic alopecia.
10 citations
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August 2020 in “Dermatologic Therapy” This study found that platelet-rich plasma significantly increased hair diameter in both men and women with androgenetic alopecia but improved hair density only in men.
1 citations
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April 2020 in “Plastic and Aesthetic Nursing” This review discusses platelet-rich plasma therapy for nonscarring alopecia and reports no new clinical results; the author recommends more large-scale controlled studies, particularly for scarring alopecia and symptom control.
2 citations
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May 2023 in “Clinical case reports” In this case report, a 34-year-old woman developed severe alopecia areata after her second COVID-19 vaccination, but her hair fully recovered following six platelet-rich plasma treatments, highlighting PRP as a potential alternative for patients who cannot tolerate or do not respond to corticosteroids.
1 citations
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January 2021 in “Indian Dermatology Online Journal” This expert group provided recommendations for preparing and using platelet-rich plasma in treating androgenetic alopecia, suggesting a manual double-spin method and specific dosing, although further studies on injectable platelet-rich fibrin are needed.
August 2020 in “Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei” This review analyzes platelet-rich plasma preparation methods for treating androgenetic alopecia but reports no new clinical results, suggesting a need for further research to evaluate efficacy and tolerance.
June 2020 in “Journal of Evolution of medical and Dental Sciences” This study found that platelet-rich plasma treatment effectively decreased hair fall and increased hair growth in male patients with androgenetic alopecia.
March 2026 in “Frontiers in Pharmacology” The study concluded that the Exprecell™ device for preparing anticoagulant-free f-PRF increases volume yield and simplifies the process while maintaining biological activity comparable to conventional methods, suggesting potential clinical utility.
February 2024 in “Journal of cutaneous and aesthetic surgery” This study reported that platelet-rich plasma therapy combined with intralesional triamcinolone acetonide was beneficial for patients with alopecia totalis, helping them reduce reliance on oral immunosuppressants.
November 2025 in “Eduvest - Journal Of Universal Studies” This case report describes a young male patient with androgenetic alopecia who experienced significant hair growth improvement and no side effects after receiving single spin platelet-rich plasma therapy combined with topical minoxidil.
6 citations
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March 2021 in “Journal of Cosmetic Dermatology” In this study, platelet-rich plasma treatment improved hair regrowth and characteristics in mice and showed therapeutic efficacy in Chinese patients with androgenetic alopecia.
6 citations
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May 2021 in “Aesthetic Surgery Journal” This study found that intradermal injections of platelet-rich plasma were equally safe and effective for treating androgenetic alopecia, with higher platelet numbers possibly enhancing hair density and follicle diameter.
26 citations
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December 2019 in “Indian Journal of Dermatology, Venereology and Leprology” This study found that platelet-rich plasma combined with topical minoxidil was more effective in increasing hair density for male-type baldness than either treatment alone.
27 citations
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January 2017 in “Indian Dermatology Online Journal” This study found no significant benefit from PRP injections for treating androgenetic alopecia in men, highlighting the need for larger, well-designed trials to assess its effectiveness and safety.
In this study, researchers found that autologous PRP injections, when used as an adjuvant treatment with topical minoxidil, did not provide a significant increase in hair density compared to placebo in men with androgenetic alopecia in northeastern India.
January 2023 in “Indian Journal of Dermatology, Venereology and Leprology” In this study, activated platelet-rich plasma improved hair density and thickness in patients with androgenetic alopecia, with higher platelet counts enhancing these effects over time.
July 2025 in “Clinical Cosmetic and Investigational Dermatology” This study found that platelet-rich plasma therapy significantly improved hair density and reduced hair shedding in Vietnamese patients with androgenetic alopecia, with high patient satisfaction and minimal side effects.
January 2023 in “Laryngoscope” This review found that while platelet-rich plasma shows potential benefits for hair restoration, there is a lack of standardized preparation and treatment protocols, necessitating further rigorous trials.
November 2023 in “Research Square (Research Square)” This double-blinded randomized clinical trial found that combining topical vitamin D analog (calcipotriol) and intra-lesion PRP led to a greater reduction in hair loss severity in alopecia areata patients compared to either treatment alone, with significant improvements observed across all groups.