research Comparison of DNA Repair Systems in Infant, Children, or Adult Skin Cells—Impact of Full-Solar-Spectrum Irradiation
Infant skin cells may be less capable of repairing UV-induced DNA damage than adult cells.
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research The De Novo DNA Methyltransferase DNMT3A Is Required for Epidermal Homeostasis
DNMT3A is crucial for healthy skin and hair growth.
research Aberrant DNA Methylation in Inflammatory Skin Diseases
DNA methylation changes are linked to skin diseases with inflammation.
research DNA Damage, Checkpoint Responses, and Cell Cycle Control in Aging Stem Cells
Maintaining DNA integrity in stem cells is crucial to prevent aging and cancer.
research Booby Trap: Cancer Gene Spurs Production of DNA-Assaulting Chemicals That Alert and Defuse Rescue Molecule
The cancer gene c-Myc increases harmful chemicals that damage DNA and can lead to cancer, but antioxidants can reduce this damage.
research Degradation of Aberrant NETs by DNases as a Therapeutic Strategy for SJS/TEN
Using DNase enzymes to break down harmful NETs could be a new treatment for Stevens-Johnson syndrome and toxic epidermal necrolysis.
research DNA Methylation Mediates LncRNA2919 Regulation of Hair Follicle Regeneration
DNA methylation controls lncRNA2919, which negatively affects hair growth.
research Haplotypes Spanning Centromeric Regions Reveal Persistence of Large Blocks of Archaic DNA
Ancient DNA blocks are still present in human genomes, possibly due to advantages they provide.
research Oxidative DNA Damage Accelerates Skin Inflammation in Pristane-Induced Lupus Model
Loss of OGG1 increases skin inflammation and auto-antibodies in lupus.
research Transient Mitochondrial DNA Double Strand Breaks in Mice Cause Accelerated Aging Phenotypes in a ROS-Dependent but p53/p21-Independent Manner
Damaging mitochondrial DNA in mice speeds up aging due to increased reactive oxygen species, not through the p53/p21 pathway.
research Evaluation of the Predictive Capacity of DNA Variants Associated with Straight Hair in Europeans
Certain DNA variants can predict straight hair in Europeans but are not highly specific.
research Finasteride-Induced Secondary Infertility Associated with Sperm DNA Damage
Finasteride use may cause sperm damage and infertility, stopping it can improve sperm health.
research Molecular–Clinical Correlations in a Family with Variable Tissue Mitochondrial DNA T8993G Mutant Load
Tissue-specific variation in mutant load complicates genetic counseling and prenatal diagnosis.
research Non-Viral Delivery of the CRISPR/Cas System: DNA Versus RNA Versus RNP
RNA delivery is best for in-body use, while RNP delivery is good for outside-body use. Both methods are expected to greatly impact future treatments.
research Treatment of Cystathionine Beta-Synthase Deficiency in Mice Using a Minicircle-Based Naked DNA Vector
MC-DNA vector-based gene therapy can temporarily treat CBS deficiency in mice.
research Mitochondrial DNA Damage, Oxidative Stress, And Atherosclerosis
Improving mitochondrial health may better treat atherosclerosis than antioxidants.
research Alterations of Plasma Antioxidants and Mitochondrial DNA Mutation in Hair Follicles of Smokers
Smoking reduces antioxidants and causes DNA damage in hair follicles.
research Acquired Immunogenicity of DNA After Modification with Malondialdehyde in Patients with Alopecia Areata
Malondialdehyde-modified DNA may trigger an immune response in alopecia areata patients.
research Beyond DNA-Targeting in Cancer Chemotherapy: Emerging Frontiers - A Review
New cancer treatments aim to reduce side effects and improve effectiveness.
research Mitochondrial DNA 10158T>C Mutation in a Patient with Mitochondrial Encephalomyopathy with Lactic Acidosis and Stroke-Like Episodes Syndrome
A patient with a rare disease had a unique genetic mutation linked to their symptoms.
research Dermapen Treatments for Healing Pockmarked Skin in Male Wistar Rats (Rattus Norvegicus): A Study Comparing Platelet-Rich Plasma with Salmon DNA Serum
PRP heals pockmarked skin better than salmon DNA serum.
research Mutational Analysis of Mitochondrial DNA in Maternal Inheritance of Polycystic Ovarian Syndrome
Mutations in mitochondrial DNA might significantly contribute to the development of Polycystic Ovarian Syndrome.
research DNA Dioxygenases TET Regulate Keratin Gene Expression and Enhancer Networks Within Lineage-Specific Gene Loci During Epidermal and Hair Follicle-Specific Keratinocyte Differentiation
TET enzymes are important for skin and hair development by controlling gene activity in specific areas.
research DNA Dioxygenases Tet1/2/3 Control Hair Matrix Keratinocyte Differentiation and Hair Shaft Shape via Regulation of Hair Keratin Gene Expression
The enzymes Tet1, Tet2, and Tet3 are important for the development of hair follicles and determining hair shape by controlling hair keratin genes.
research Smart DNA Biosensor for In Vitro Detection of Androgen Receptor mRNA
A new easy-to-use biosensor was made to detect androgen receptor mRNA, which could help diagnose related conditions quickly.
research Fidelity of the Human Mitochondrial DNA Polymerase
Human mitochondrial DNA polymerase makes very few errors, crucial for preventing degenerative diseases.
research Lymphoid Enhancer-Binding Factor-1 Interacts with the DNA-Binding Domain of the Vitamin D Receptor
LEF1 interacts with Vitamin D Receptor, affecting hair follicle regeneration and this could be linked to hair loss conditions.
research Pantothenic Acid Promotes Dermal Papilla Cell Proliferation in Hair Follicles of American Minks via Inhibitor of DNA Binding 3/Notch Signaling Pathway
Pantothenic acid helps mink hair follicles grow by affecting certain cell signals.
research In Vivo Role of Vitamin D Receptor Signaling in UVB-Induced DNA Damage and Melanocyte Homeostasis
Vitamin D receptor helps protect skin cells from UV damage and supports their growth.
research Elevation of Circulating DNAs of Disease-Associated Cytokines in Serum Cell-Free DNA from Patients with Alopecia Areata
Higher levels of certain DNAs in blood may indicate hair follicle damage in alopecia areata patients.