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This study reviewed 16 notable drug repurposing patent applications from 2025, highlighting potential new uses such as guanfacine for autonomic dysfunction and disulfiram for subarachnoid hemorrhage survival, though many disclosures lack peer-reviewed studies and no patents are granted.

In this study, hair shafts from trichothiodystrophy patients with ERCC2 mutations revealed abnormal cuticle structures and protein imbalances compared to normal hair shafts.

This study assessed three materials—L-arginine, hydrolysed keratin, and cystine-silanol copolymer—ex vivo for their potential to reduce undesirable effects of hair bleaching, such as damage to hair proteins.

This study compared the effects of three compounds on structural and sensory benefits for bleached hair when applied with or after bleaching, observing that their application may mitigate bleaching-induced damage.

This study found that acute UVB exposure in mice increases the synthesis of retinoic acid in the epidermis, which is necessary for normal repair from UVB light.

This study observed that hydrophobic modifications of hair matrix proteins significantly alter the humidity-dependent glass transition temperature of human hair.

This study found that inhibiting retinoic acid synthesis in mouse hair follicles allowed WNT signaling to remain active, suggesting potential implications for developing treatments for hair disorders and skin cancer.

This review covers various aspects of hair biology, pigmentation, and development, focusing on genetic and biochemical modulation of hair follicle components but reports no new findings.

This study found that CMAD wool keratin may protect human hair from damage during repeated bleaching and permanent waving treatments.

This study found that the extent of reducing agents' effects on hair fibers was linked to the electrode potential of the reagents used.

This study found that using a bicomponent reduction system with TGA and DTDG for hair straightening limited hair damage by forming only thiol groups, while a TGA-only system formed more damaging mixed disulfide groups.

This article reviews seborrheic scalp dermatitis management in Italy, outlining expert recommendations on diagnosis and treatment, but reports no new clinical results.

This study evaluated quercetin's potential as a treatment for cats with Feline Atopic Skin Syndrome, finding it significantly reduced clinical scores in certain symptom groups like Head-and-Neck Pruritus and Miliary Dermatitis, although improvements in oxidative stress markers were not clearly significant.

This study found that individuals with acne vulgaris had significantly higher serum total thiol and thiol disulfide levels, as well as a reduced total thiol/thiol disulfide ratio, compared to healthy controls.

In this study, carboxymethylalanyl disulfide keratin was shown to effectively prevent hair damage during repeated bleaching and permanent waving treatments.

This review discusses temporary chemical hair removal methods involving thioglycolates and other compounds but reports no new clinical findings; the authors highlight interest in natural-based substances.

In this study, researchers observed that cosmetic peroxide bleaching causes oxidative damage and protein loss in human hair, not only affecting the cuticle but also deeper cortical structures, correlating with bleaching severity.

In their 1957 study, Neuman and Neuman suggested that magnesium deficiency may inhibit the ion exchange process required for calcium ions to enter extracellular fluid, potentially affecting calcium mobilization.

This study describes the structure and composition of the epidermal horny layer in elephant seals, noting that its keratinized cells are attached without a specialized fission zone, differing from the sloughing mechanism in reptiles.

This study found that PX-12 inhibited the NLRP3 inflammasome and reduced psoriasis-like symptoms in a mouse model, suggesting its potential as a treatment for psoriasis.

This research provides insights into how keratin hydrogels, modified to control disulfide crosslinking, may function as a treatment platform for bone injuries.

This study developed a new synthetic route for finasteride that omits the costly reagent 2,2′ dipyridyl disulfide, achieving an overall yield of 16%.

This study found that shikimic acid- and maleate-based hair repair agents modified the structure of hair fibers, though they did not increase disulfide bridge content in the hair cortex.

In 2002, various drugs caused serious side effects, including vitamin B12 deficiency, heart issues, blindness, hypersexuality, allergic reactions, blood clotting problems, pupil dilation, capillary leak syndrome, muscle breakdown, hepatitis, skin reactions, and lupus.

This study developed a multifunctional TA-MoS2-SF hydrogel for diabetic ulcer treatment, demonstrating enhanced photothermal bactericidal effects, immune environment remodeling, and fibroblast proliferation, suggesting it may serve as an effective 'antibacterial-immunomodulatory-repair' strategy.

This study synthesized and evaluated five 6-mercaptopurine derivatives for anticancer activity against three cancer cell lines, detailing the promising results of compound 1.

This review summarizes the roles of PDGF and its receptors in cell development and wound healing, reporting no new research findings; the authors emphasize PDGF's diverse biological functions.

This study demonstrated that keratin can be effectively extracted from wool using alkaline solutions and that the extracted keratin maintains reactivity similar to that from other low-value sources like cattle hair.

This study found that the extraction-resistant structures in hair, feathers, and hagfish teeth are due to ε-(γ-glutamyl)lysine cross-linked proteins, emphasizing their role in maintaining the integrity of these materials.

This study found that astrotactin-2 undergoes unique intramembrane proteolysis during maturation, revealing specific transmembrane topologies and substrate sequence requirements for cleavage.