June 2026 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, researchers developed and tested an herbal antidandruff shampoo using plant extracts like neem, fenugreek seed, aloe vera, and clove, demonstrating antibacterial and antifungal activity against common scalp microbes and offering a potential natural alternative for dandruff treatment.
May 2026 in “Carbohydrate Polymer Technologies and Applications” This study found that the carbohydrate-based excipient β-cyclodextrin forms a stable inclusion complex with the active ingredient of Minoxicapil®, potentially enhancing its formulation for hair-loss treatment, and in vitro assays suggest improved proliferation of DPC cells, supporting its use in topical treatments.
March 2026 in “Jurnal Ilmiah Ibnu Sina (JIIS) Ilmu Farmasi dan Kesehatan” In this in vitro study, the researchers found that garden balsam leaf extract serum showed no antifungal inhibition against Candida albicans, while the positive control, a 2% ketoconazole shampoo, demonstrated a strong effect.
September 2024 in “Journal of Cosmetic Dermatology” This study found that quercetin-loaded solid lipid nanoparticles demonstrated positive protective effects on human hair against UV-B light, as they controlled microscopic surface roughness, reduced chemical changes, and minimized protein loss in vitro compared to other treatments.
November 2014 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study suggests that nanostructured lipid carriers loaded with spironolactone might improve localized delivery to hair follicles for treating androgenic alopecia, potentially minimizing systemic side effects.
January 2013 in “Elsevier eBooks” This review discusses spatial and temporal patterns in animals, focusing on skin appendage organs, but provides no new research findings.
80 citations
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January 2011 in “Clinical Chemistry and Laboratory Medicine (CCLM)” This study confirmed that the diffusion of cortisol from blood is a biologically endogenous source of hair cortisol, correlating significantly with salivary cortisol levels in healthy humans.
8 citations
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January 2016 in “Journal of fiber science and technology” This study found that cysteic acid generation during hair bleaching is diffusion-controlled, increasing with the square root of bleaching time, in both cuticles and cortex of human hair fibers.
1 citations
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June 2007 in “Almustansiriya journal of pharmaceutical sciences/Al-Mustansiriyah journal of pharmaceutical sciences” This study found that a cimetidine 10% cream with sodium lauryl sulphate significantly increased drug diffusion through mouse skin and showed promise in treating warts in a preliminary clinical trial.
4 citations
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June 2024 in “Animals” This study found that treating dogs with benign prostatic hyperplasia using osaterone acetate reduced prostatic volume and increased diffusion times of an ultrasound contrast agent, suggesting effective treatment and potential for CEUS monitoring.
2 citations
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November 2024 in “Aesthetic Surgery Journal” This study found that vibration anesthesia significantly reduced pain during botulinum toxin injections for masseter reduction without affecting the injection's diffusion or causing adverse effects, and high patient satisfaction was also reported.
61 citations
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June 2010 in “European Journal of Pharmaceutics and Biopharmaceutics” This study found that liposomes coated with cationic polymers, chitosan and Eudragit EPO, showed improved physicochemical stability and enhanced skin diffusion of aciclovir and minoxidil compared to uncoated liposomes.
35 citations
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October 2005 in “European journal of pharmaceutics and biopharmaceutics” This study found that polymers significantly improved the chemical and microbial stability of steroid hormones in liposome formulations over eight weeks, with finasteride showing the highest diffusion rate.
24 citations
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March 2018 in “Brazilian Journal of Pharmaceutical Sciences” This study found that unripe and ripe Musa sapientum fruit extracts may exhibit hypoglycemic effects by inhibiting α-amylase activity, reducing glucose diffusion, and promoting glucose uptake in yeast cells.
18 citations
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July 2003 in “Dermatologic Surgery” This study identified five distinct scalp whorl patterns, noting that white males have the most distinct whorls, while African Americans and women more often exhibit a diffusion pattern.
1 citations
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October 2020 in “Annales pharmaceutiques françaises” In this study, researchers developed and validated a rapid and robust chromatographic method to assess the concentration of Minoxidil and Finasteride in a new topical formulation for alopecia, demonstrating its ability to distinguish between different types of formulations using in vitro diffusion data.
1 citations
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January 2007 The study found that stratum corneum thickness and total epidermal lipid content influence the permeation rates of certain nonsteroidal anti-inflammatory drugs in various animal skin models, and suggests porcine skin as an effective human replacement in diffusion experiments.
April 2026 in “Lithuanian University of Health Sciences” In this study, cinnamic acid in solution form showed strong antifungal activity against Microsporum canis, but when incorporated into hydrogels, the acid's diffusion and resulting antifungal performance decreased, though it maintained effectiveness for potential prolonged exposure.
January 2026 in “Drug Delivery and Translational Research” This study investigated the integration of crystal engineering and microneedle technology for androgenetic alopecia treatment, finding that microneedles loaded with newly developed Kopexil multicomponent crystals reduced drug diffusion rates in vitro compared to standard formulations.
June 2025 in “Formosa Journal of Sustainable Research” In this study, the NADES extract of mangkokan leaves (Polyscias scutellaria) demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus, with a total flavonoid content measured at 4.944 mgEQ/gSimplisia using the disc diffusion method.
August 2022 in “Scholars academic journal of pharmacy” This study involved formulating an invasome gel loaded with clotrimazole for treating fungal infections and assessed its various properties like spreadability and in vitro drug diffusion.
May 2018 in “Digital ProScholar Media eBooks” This study evaluated the antimicrobial activity of a newly synthesized fluoroquinolone against Staphylococcus, Streptococcus, and Escherichia coli strains. The researchers compared results from the microdilution technique and agar disk diffusion method to EUCAST's recommended breakpoint values, building on promising in silico molecular docking tests.
January 2018 in “Iranian Journal of Pharmaceutical Sciences” In this laboratory study, eucalyptus oil, menthol, and urea were found to enhance the skin permeability of minoxidil in rat skin by increasing flux and diffusion coefficients compared to untreated skin.
January 2012 in “Journal of Cosmetics Dermatological Sciences and Applications” This study found that iontophoresis significantly enhances the skin penetration of magnesium salt of L-ascorbic acid 2-phosphate, especially in hairy mice, compared to passive diffusion.
August 2003 in “Dermatologic Surgery” This study identified five distinct natural scalp whorl patterns and noted that White males have more distinct whorls, whereas African Americans and women often display a diffusion pattern.
January 2022 in “Journal of Cosmetic Dermatology” This study found that placebo groups in split-scalp PRP trials for androgenetic alopecia showed less hair loss compared to whole-head trial placebo groups, likely due to PRP diffusion in split-scalp designs.
35 citations
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June 2017 in “Pharmacognosy Journal” This study found that alkaloids isolated from Eclipta alba leaves showed increasing antimicrobial activity with higher concentrations, particularly against S. aureus and E. coli, suggesting potential for developing antimicrobial agents.
January 2022 in “JPK Jurnal Proteksi Kesehatan” This study found that the ethanol extract of mangkokan leaf (Polyscias scutellarium) demonstrated antibacterial activity against Escherichia coli and Staphylococcus aureus, with higher concentrations showing greater inhibition zones, particularly against Staphylococcus aureus.
39 citations
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August 2017 in “Colloids and Surfaces B: Biointerfaces” This study found that 50-nm PLGA nanoparticles delivered with iontophoresis enhanced skin permeation of indomethacin in rats more effectively than 100-nm nanoparticles, suggesting improved targeting of hair follicles.
31 citations
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September 2011 in “European journal of pharmaceutics and biopharmaceutics” This study found that biodegradable PLA particles released fluorochromes in a time-dependent manner on human skin, with BP-PLA particles releasing rapidly and DiAsp-PLA particles providing sustained release and accumulation in hair follicles.