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    Glossary Dickkopf-related protein 4

    regulates Wnt signaling, affecting hair follicle development and cycling

    Dickkopf-related protein 4 (Dkk4) is a protein that plays a crucial role in regulating the Wnt signaling pathway, which is important for cell growth, development, and differentiation. In the context of hair biology, Dkk4 can influence hair follicle development and cycling, and its dysregulation has been associated with conditions like alopecia, where hair loss occurs.

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    Research 30 of 503

    1. Dickkopf-related Protein 2 Promotes Hair Growth by Upregulating the Wnt/β-catenin Signaling Pathway in Human Dermal Papilla Cells Annals of Dermatology · 2024 · 6 citations
    2. Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing β-Catenin Stem cells · 2013 · 3 citations
    3. Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately Stem Cell Research & Therapy · 2015 · 113 citations
    4. Wnt signaling in skin organogenesis Organogenesis · 2008 · 72 citations
    5. Visible-to-Near IR Quantum Dot–Based Hypermulticolor High-Content Screening of Herbal Medicines for the Efficacy Monitoring of Hair Growth Promotion and Hair Loss Inhibition SLAS discovery · 2012 · 14 citations
    6. Deciphering Early-Stage Molecular Mechanisms of Negative Pressure Wound Therapy in a Murine Model International Journal of Molecular Sciences · 2024 · 2 citations
    7. Hair Growth Promoting Effects of Limosilactobacillus reuteri Isolated from Honeybee through Wnt/β-catenin Signal Transduction Journal of the Korean Society of Cosmetology · 2026
    8. DKK4 as a novel candidate marker for Zhexi Angora rabbit wool quality World Rabbit Science · 2026
    9. Hair Growth Effect and the Mechanisms of Rosa rugosa Extract in DHT-Induced Alopecia Mice Model International Journal of Molecular Sciences · 2024
    10. Hair growth–promoting effects of Enz_MoriL on human dermal papilla cells through modulation of the Wnt/β-Catenin and JAK-STAT signaling pathways Archives of dermatological research · 2024
    11. Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin International journal of molecular sciences · 2024
    12. 1332 Janus kinase inhibitor increases hair growth by increasing beta-catenin activity in outer root sheath cells 2023
    13. 1365 Interest of Biotrinine®, a mix of Nasturtium officinale and Tropaeolum majus extracts, for chronic hair loss treatment 2018
    14. Proteomics Characterization of Primary Human Oral Epithelial Cells Using a Novel Culture Technique for Use in Tissue Regeneration MOJ proteomics & bioinformatics · 2015
    15. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007 · 171 citations
    16. Therapeutic Potentiality of Celtis choseniana Nakai on Androgenic Alopecia through Repression of Androgen Action and Modulation of Wnt/β-catenin Signaling Natural product sciences · 2023
    17. Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle Stem Cells International · 2017 · 8 citations
    18. The Dickkopf Protein Family in Non-Neoplastic Disorders: Emerging Roles and Therapeutic Targeting Aging and Disease · 2026
    19. Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles PeerJ · 2019 · 7 citations
    20. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020 · 23 citations
    21. Expression of Signaling Components in Embryonic Eyelid Epithelium PloS one · 2014 · 5 citations
    22. 1343 Efficacy of asymmetric siRNA targeting androgen receptor for the treatment of androgenetic alopecia Journal of Investigative Dermatology · 2023
    23. SFRP2 augments Wnt/β-catenin signalling in cultured dermal papilla cells Experimental Dermatology · 2016 · 17 citations
    24. Acquired curved hair is caused by fusion of multiple hair matrix cells Journal of Dermatological Science · 2024
    25. Millet seed oil activates β–catenin signaling and promotes hair growth Frontiers in Pharmacology · 2023 · 1 citations
    26. Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor Biochemical and Biophysical Research Communications · 2020 · 4 citations
    27. Hoxc13 polyglycine repeat gain-of-function drives mammalian integument evolution by altering targeted genes and interactions Research Square · 2026
    28. Effects of Allium hookeri Extracts on Hair-Inductive and Anti-Oxidative Properties in Human Dermal Papilla Cells Plants · 2023 · 2 citations
    29. Expression of the Wnt signaling pathway and hair follicle development in  Rex rabbits of different ages 2025
    30. A preliminary study of differentially expressed genes in expanded skin and normal skin: implications for adult skin regeneration Archives of Dermatological Research · 2011 · 16 citations