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    Glossary Dickkopf-related protein 4

    regulates Wnt signaling, affecting hair follicle development and cycling

    Dickkopf-related protein 4 (Dkk4) is a protein that plays a crucial role in regulating the Wnt signaling pathway, which is important for cell growth, development, and differentiation. In the context of hair biology, Dkk4 can influence hair follicle development and cycling, and its dysregulation has been associated with conditions like alopecia, where hair loss occurs.

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    Research 30 of 526

    1. Dickkopf-related Protein 2 Promotes Hair Growth by Upregulating the Wnt/β-catenin Signaling Pathway in Human Dermal Papilla Cells Annals of Dermatology · 2024 · 6 citations
    2. Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin International journal of molecular sciences · 2024
    3. Visible-to-Near IR Quantum Dot–Based Hypermulticolor High-Content Screening of Herbal Medicines for the Efficacy Monitoring of Hair Growth Promotion and Hair Loss Inhibition SLAS discovery · 2012 · 14 citations
    4. Wnt signaling in skin organogenesis Organogenesis · 2008 · 72 citations
    5. DKK4 as a novel candidate marker for Zhexi Angora rabbit wool quality World Rabbit Science · 2026
    6. Deciphering Early-Stage Molecular Mechanisms of Negative Pressure Wound Therapy in a Murine Model International Journal of Molecular Sciences · 2024 · 2 citations
    7. Hair Growth Promoting Effects of Limosilactobacillus reuteri Isolated from Honeybee through Wnt/β-catenin Signal Transduction Journal of the Korean Society of Cosmetology · 2026
    8. Hair Growth Effect and the Mechanisms of Rosa rugosa Extract in DHT-Induced Alopecia Mice Model International Journal of Molecular Sciences · 2024
    9. Therapeutic Potentiality of Celtis choseniana Nakai on Androgenic Alopecia through Repression of Androgen Action and Modulation of Wnt/β-catenin Signaling Natural product sciences · 2023
    10. Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately Stem Cell Research & Therapy · 2015 · 113 citations
    11. Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing β-Catenin Stem cells · 2013 · 3 citations
    12. Proteomics Characterization of Primary Human Oral Epithelial Cells Using a Novel Culture Technique for Use in Tissue Regeneration MOJ proteomics & bioinformatics · 2015
    13. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007 · 171 citations
    14. 1365 Interest of Biotrinine®, a mix of Nasturtium officinale and Tropaeolum majus extracts, for chronic hair loss treatment 2018
    15. 1332 Janus kinase inhibitor increases hair growth by increasing beta-catenin activity in outer root sheath cells 2023
    16. Paracrine Secreted Frizzled-Related Protein 4 Inhibits Melanocytes Differentiation in Hair Follicle Stem Cells International · 2017 · 8 citations
    17. Hair growth–promoting effects of Enz_MoriL on human dermal papilla cells through modulation of the Wnt/β-Catenin and JAK-STAT signaling pathways Archives of dermatological research · 2024
    18. SFRP2 augments Wnt/β-catenin signalling in cultured dermal papilla cells Experimental Dermatology · 2016 · 17 citations
    19. Secreted Frizzled-related protein 4 inhibits the regeneration of hair follicles PeerJ · 2019 · 7 citations
    20. The Dickkopf Protein Family in Non-Neoplastic Disorders: Emerging Roles and Therapeutic Targeting Aging and Disease · 2026
    21. An Intrinsic Oscillation of Gene Networks Inside Hair Follicle Stem Cells: An Additional Layer That Can Modulate Hair Stem Cell Activities Frontiers in Cell and Developmental Biology · 2020 · 23 citations
    22. Effects of Allium hookeri Extracts on Hair-Inductive and Anti-Oxidative Properties in Human Dermal Papilla Cells Plants · 2023 · 2 citations
    23. Panax ginseng extract antagonizes the effect of DKK-1-induced catagen-ike changes of hair follicles International Journal of Molecular Medicine · 2017 · 15 citations
    24. Blockade of Androgen Markers Using a Novel Betasitosterol, Thioctic Acid and Carnitine-containing Compound in Prostate and Hair Follicle Cell-based Assays Phytotherapy Research · 2016 · 3 citations
    25. Acquired curved hair is caused by fusion of multiple hair matrix cells Journal of Dermatological Science · 2024
    26. Millet seed oil activates β–catenin signaling and promotes hair growth Frontiers in Pharmacology · 2023 · 1 citations
    27. A preliminary study of differentially expressed genes in expanded skin and normal skin: implications for adult skin regeneration Archives of Dermatological Research · 2011 · 16 citations
    28. Hair Regenerative Mechanisms of Red Ginseng Oil and Its Major Components in the Testosterone-Induced Delay of Anagen Entry in C57BL/6 Mice Molecules · 2017 · 33 citations
    29. Expression of Signaling Components in Embryonic Eyelid Epithelium PloS one · 2014 · 5 citations
    30. Developmental genetics of color pattern establishment in cats Nature communications · 2021 · 20 citations