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    Glossary Dickkopf-1

    inhibits hair follicle formation, contributing to hair loss

    Dickkopf-1 (DKK1) is a protein that plays a crucial role in regulating cell signaling pathways, particularly the Wnt signaling pathway, which is important for cell growth and development. In the context of hair biology, DKK1 is known to inhibit hair follicle formation and is associated with conditions like androgenetic alopecia (pattern baldness), where its elevated levels can lead to hair loss.

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    Research 30 of 601

    1. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007 · 171 citations
    2. The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis Developmental biology · 2007 · 96 citations
    3. Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosteroneinduced dickkopf-1 expression in human hair dermal papilla cells BMB Reports · 2010 · 31 citations
    4. I‐Ascorbic acid 2‐phosphate represses the dihydrotestosterone‐induced dickkopf‐1 expression in human balding dermal papilla cells Experimental Dermatology · 2010 · 13 citations
    5. Assessment of tissue levels of dickkopf-1 in androgenetic alopecia and alopecia areata Journal of Cosmetic Dermatology · 2015 · 10 citations
    6. Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients American Journal of Dermatopathology · 2019 · 9 citations
    7. Dickkopf-related Protein 2 Promotes Hair Growth by Upregulating the Wnt/β-catenin Signaling Pathway in Human Dermal Papilla Cells Annals of Dermatology · 2024 · 6 citations
    8. Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor Biochemical and Biophysical Research Communications · 2020 · 4 citations
    9. Attenuation of Dickkopf 1-Induced Hair Growth Inhibition in Cultured Human Hair Follicles by Tianeptine Annals of Dermatology · 2017 · 4 citations
    10. Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosteroneinduced dickkopf-1 expression in human hair dermal papilla cells BMB Reports · 2010 · 2 citations
    11. The Dickkopf Protein Family in Non-Neoplastic Disorders: Emerging Roles and Therapeutic Targeting Aging and Disease · 2026
    12. Serum Dicckopf-1 Level in Patients of Cicatricial and Non- Cicatricial Alopecia Benha Journal of Applied Sciences · 2022
    13. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis Development · 2004 · 293 citations
    14. Wnt and Notch signaling pathway involved in wound healing by targeting c-Myc and Hes1 separately Stem Cell Research & Therapy · 2015 · 113 citations
    15. Wnt signaling in skin organogenesis Organogenesis · 2008 · 72 citations
    16. Dynamic Signals for Hair Follicle Development and Regeneration Stem Cells and Development · 2011 · 60 citations
    17. Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia Molecular and Cellular Endocrinology · 2016 · 47 citations
    18. Developmental genetics of color pattern establishment in cats Nature communications · 2021 · 20 citations
    19. Panax ginseng extract antagonizes the effect of DKK-1-induced catagen-ike changes of hair follicles International Journal of Molecular Medicine · 2017 · 15 citations
    20. Visible-to-Near IR Quantum Dot–Based Hypermulticolor High-Content Screening of Herbal Medicines for the Efficacy Monitoring of Hair Growth Promotion and Hair Loss Inhibition SLAS discovery · 2012 · 14 citations
    21. May the best wound WIHN: the hallmarks of wound-induced hair neogenesis Current Opinion in Genetics & Development · 2021 · 9 citations
    22. Developmental Genetics of Color Pattern Establishment in Cats bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 6 citations
    23. Effects of watercress extract fraction on R‐spondin 1‐mediated growth of human hair International Journal of Cosmetic Science · 2022 · 4 citations
    24. Partial Proteasome Inhibitors Induce Hair Follicle Growth by Stabilizing β-Catenin Stem cells · 2013 · 3 citations
    25. Deciphering Early-Stage Molecular Mechanisms of Negative Pressure Wound Therapy in a Murine Model International Journal of Molecular Sciences · 2024 · 2 citations
    26. <i>Melandrium firmum</i>Extract Promotes Hair Growth by Modulating 5α-Reductase Activity and Gene Expression in C57BL/6J Mice Annals of Dermatology · 2019 · 2 citations
    27. 726 The Wnt-inhibitor Dkk4 is required for primary hair follicle induction and patterning Journal of Investigative Dermatology · 2022
    28. 318 The Wnt-inhibitor Dkk4 is required for primary hair follicle induction and patterning Journal of Investigative Dermatology · 2021
    29. Hair Growth Promoting Effects of Limosilactobacillus reuteri Isolated from Honeybee through Wnt/β-catenin Signal Transduction Journal of the Korean Society of Cosmetology · 2026
    30. DKK4 as a novel candidate marker for Zhexi Angora rabbit wool quality World Rabbit Science · 2026