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    Glossary DHT Inhibition

    reducing dihydrotestosterone to prevent hair loss

    DHT inhibition refers to the process of reducing the activity or production of dihydrotestosterone (DHT), a hormone derived from testosterone. DHT is known to contribute to hair loss, particularly in conditions like androgenetic alopecia (male or female pattern baldness). By inhibiting DHT, treatments aim to slow down or prevent hair loss and promote hair regrowth.

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    1. Pharmacokinetic parameters and mechanisms of inhibition of rat type 1 and 2 steroid 5α-reductases: determinants for different in vivo activities of GI198745 and finasteride in the rat 3 3Abbreviations: r5AR1, rat 5α-reductase 1; r5AR2, rat 5α-reductase 2; and DHT, dihydrotestosterone. Biochemical Pharmacology · 2001 · 22 citations
    2. Dutasteride, a novel dual 5-A reductase inhibitor, reduces serum DHT to a greater extent versus finasteride and achieves finasteride maximal reduction in a larger proportion of patients European Urology Supplements · 2003 · 12 citations
    3. Necrosulfonamide promotes hair growth and ameliorates DHT-induced hair growth inhibition Journal of Dermatological Science · 2024 · 2 citations
    4. Topical MK-386 (M), an inhibitor of 5α-reductase (5αr) type I, suppresses sebum dht. Clinical Pharmacology & Therapeutics · 1996
    5. Aromatase-independent testosterone conversion into estrogenic steroids is inhibited by a 5α-reductase inhibitor The Journal of Steroid Biochemistry and Molecular Biology · 2005 · 44 citations
    6. Pharmacological inhibition of 5α-reductase in androgenetic alopecia: a comparative narrative review of finasteride and dutasteride, with attention to responder heterogeneity and female pattern hair loss Zenodo (CERN European Organization for Nuclear Research) · 2026
    7. Pharmacological inhibition of 5α-reductase in androgenetic alopecia: a comparative narrative review of finasteride and dutasteride, with attention to responder heterogeneity and female pattern hair loss Zenodo (CERN European Organization for Nuclear Research) · 2026
    8. Natural phenylethanoid glycoside forsythoside A alleviates androgenetic alopecia by selectively inhibiting TRPV3 channels in mice European Journal of Pharmacology · 2025
    9. Discovery of a novel and highly selective JAK3 inhibitor as a potent hair growth promoter Journal of translational medicine · 2024
    10. SAT-288 Successful Virilization of a PAIS Patient with a Missense Mutation In The Ligand-binding Domain Of The Androgen Receptor with Combined High-dose Testosterone and Aromatase Inhibitor Journal of the Endocrine Society · 2019
    11. FCE 28260, a new 5α-reductase inhibitor: In vitro and in vivo effects The Journal of Steroid Biochemistry and Molecular Biology · 1996 · 17 citations
    12. Hemp Seed-Derived Exosomes Protect Against Dihydrotestosterone-Induced Chicken Feather Growth Inhibition Pharmaceuticals · 2025
    13. COMBINATION OF AN ANTIANDROGEN AND A 5α-REDUCTASE INHIBITOR: A FURTHER STEP TOWARDS TOTAL ANDROGEN BLOCKADE? Endocrinology · 1991 · 9 citations
    14. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor 2004 · 408 citations
    15. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007 · 195 citations
    16. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996 · 136 citations
    17. The dihydrotestosterone (DHT) hypothesis of prostate cancer and its therapeutic implications The Prostate · 1986 · 57 citations
    18. Overexpression of aldo-keto reductase 1C3 (AKR1C3) in LNCaP cells diverts androgen metabolism towards testosterone resulting in resistance to the 5α-reductase inhibitor finasteride The Journal of Steroid Biochemistry and Molecular Biology · 2012 · 45 citations
    19. Inhibition of Rat 5<i>α</i>-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of<i>Quercus acutissima</i>Cortex Evidence-based Complementary and Alternative Medicine · 2015 · 37 citations
    20. Inhibition of the Androgen Receptor by Antisense Oligonucleotides Regulates the Biological Activity of Androgens in SZ95 Sebocytes Hormone and metabolic research · 2007 · 29 citations
    21. Inhibition of 5α-Reductase Activity in SZ95 Sebocytes and HaCaT Keratinocytes <i>In Vitro</i> Hormone and metabolic research · 2007 · 24 citations
    22. Consequences of steroid-5α-reductase deficiency and inhibition in vertebrates General and Comparative Endocrinology · 2020 · 21 citations
    23. Inhibition of steroid 5 alpha-reductase with finasteride: sleep-related erections, potency, and libido in healthy men. The Journal of Clinical Endocrinology and Metabolism · 1995 · 15 citations
    24. Aromatase inhibition by letrozole attenuates kainic acid-induced seizures but not neurotoxicity in mice Epilepsy research · 2018 · 11 citations
    25. Oral Testosterone With and Without Concomitant Inhibition of 5α-Reductase by Dutasteride in Hypogonadal Men for 28 Days The Journal of Urology · 2010 · 11 citations
    26. Finasteride-Induced Inhibition of 5α-Reductase Type 2 Could Lead to Kidney Damage—Animal, Experimental Study International Journal of Environmental Research and Public Health · 2019 · 10 citations
    27. Steady-state pharmacokinetics of oral testosterone undecanoate with concomitant inhibition of 5α-reductase by finasteride International Journal of Andrology · 2010 · 10 citations
    28. Effects of the anti-androgen finasteride on 5α-reduction of androgens in the presence of progesterone in human gingival fibroblasts: modulatory actions of the alkaline phosphatase inhibitor levamisole Journal of Periodontal Research · 2000 · 9 citations
    29. Inhibition of 5α-reductase in the rat prostate by Cimicifuga racemosa Maturitas · 2006 · 7 citations
    30. Inhibition of lipogenesis and sebum secretion for <i>Lotus corniculatus</i> seed extract in vitro and in vivo International Journal of Cosmetic Science · 2022 · 1 citations