291 citations
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October 2005 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that rat whisker follicle stem cells can be expanded in culture and transplanted to form functional hair follicles, demonstrating their multipotency and potential for regenerative medicine.
December 2023 in “The journal of cell biology/The Journal of cell biology” This study developed the mTurquoise2-Col4a1 mouse model and used fluorescent tagging of collagen IV to offer new insights into basement membrane dynamics during hair follicle budding, revealing that basement membranes are flexible and stable structures in developing skin tissue.
September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that deleting all three Tet genes in mice led to shorter hair shafts and altered hair types, with associated changes in gene expression and DNA hydroxymethylation.
205 citations
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August 2007 in “Experimental Cell Research” This review discusses advances in understanding mammalian stem cell niches, particularly in bone marrow, tooth, and hair follicle, and highlights the potential for developing therapies targeting these niches for tissue repair.
142 citations
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June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This workshop overview concluded that follicular epithelial stem cells are multipotent and located in the bulge region of hair follicles, contributing to hair, epidermis, and sebaceous gland formation.
123 citations
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January 2020 in “International Journal of Molecular Sciences” This review discusses the role of fibroblast heterogeneity in determining skin scarring versus regeneration and reports no new results, highlighting opportunities for developing antiscarring therapies.
69 citations
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December 2011 in “Journal of Ethnopharmacology” This study found that Carthamus tinctorius exhibited the strongest 5α-reductase inhibitory and hair growth promoting activities among evaluated Thai herbs, suggesting potential for developing alternative hair loss treatments.
41 citations
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September 2010 in “Journal of dermatological science” This study suggests that mesenchymal stem cell-induced dermal papilla-like tissues can generate new hair follicles in mice, indicating potential for developing hair cell therapy using stem cells.
31 citations
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May 2008 in “Drug Discovery Today: Disease Mechanisms” This review discusses the physiology of hair follicles, their disorders, and the principles behind developing treatments, reporting no new results.
24 citations
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January 2008 in “KARGER eBooks” This review discusses recent advances in understanding the pathogenesis of autoimmune alopecia areata and reports no new clinical results; it highlights potential for developing more effective treatments.
9 citations
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November 2018 in “Drug Discovery Today” This review discusses insights from scar-free animal models and cellular factors in skin regeneration, suggesting potential strategies for developing scar-free treatments in clinical and cosmetic practices, but reports no new clinical results.
7 citations
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March 2005 in “Journal of dermatological science” This study found that apoptosis, along with proliferation, plays a crucial role in shaping and extending human hair follicles by coordinating the formation and differentiation of the hair canal.
4 citations
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November 2023 in “Frontiers in immunology” In this narrative review, researchers outlined the role of T cells in the autoimmune pathogenesis of alopecia areata and highlighted ongoing research into therapeutic pathways, beyond current JAK inhibitors, aimed at developing new treatments for the disease.
3 citations
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January 2016 in “BioMed research international” This study found that calcium microcapsules exhibited better biocompatibility and cell viability than barium microcapsules for scaffolding in artificial dermal papilla, suggesting potential for developing new hair follicle structures.
3 citations
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January 2011 in “Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE” This study found that variations in mouse skin thickness, influenced by gender and hair growth cycles, significantly affect optical scattering measurements, which are important for developing biomedical optics techniques.
3 citations
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November 2005 in “Dermatologic Surgery” This study found that aminoguanidine induced increased VEGF mRNA expression in stored hair follicle micrografts, suggesting potential for developing growth-promoting storage solutions in hair restoration surgery.
2 citations
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January 2022 in “Journal of Investigative Dermatology” This study reported that Hedgehog signaling in papillary fibroblasts is crucial for hair follicle regeneration during wound healing, emphasizing its potential for developing regenerative therapies in scarring wounds.
1 citations
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October 2022 in “Annual review of cell and developmental biology” This review discusses the roles of peripheral nerves in stem cell and immune responses within the skin and hematopoietic system, emphasizing their potential in developing new therapies; it reports no new experimental results.
1 citations
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June 2021 in “Biomolecules & Therapeutics” In this study, researchers found that activating the delta opioid receptor with a specific agonist significantly promoted hair growth in mice, suggesting potential for developing new hair-loss treatments.
August 2025 in “Галицький медичний вісник” This study examines the pathogenetic mechanisms and morphological changes in androgenetic alopecia, highlighting the role of genetic and hormonal factors like dihydrotestosterone in hair follicle changes, which is crucial for developing effective diagnostics and treatments.
January 2025 in “PLoS ONE” This study found that aligned electrospinning membranes enhance skin wound healing by upregulating MMP12 expression and inhibiting fibroblast migration, which results in reduced scar formation, providing valuable insights for developing more effective biological dressings.
May 2024 in “Molecules/Molecules online/Molecules annual” This narrative review reports that well-selected plant extracts and their active compounds may improve hair health by promoting hair growth and preventing hair loss, potentially aiding in developing targeted therapies for alopecia.
February 2024 in “Journal of medicinal food” This study reports that the β-catenin inhibitor tegatrabetan reduced hair growth and hair follicle numbers in mice, suggesting its potential as a model for developing new hair growth materials.
November 2023 in “Journal of Bioscience and Bioengineering” This review highlights the potential of exosomes, particularly their microRNA components, as promising candidates for developing effective hair loss treatments by exploring their roles in hair follicle development and regeneration.
October 2023 in “Scientific Reports” This study explored the effects of oxytocin on hair growth and found that it upregulated growth-promoting factors in dermal papilla cells and hair follicle organoids, suggesting potential for developing new alopecia treatments.
December 2021 in “Research Square (Research Square)” This study found that repeatedly collecting hair follicles from individuals with fragile X syndrome is feasible for measuring FMR1 and FMRP levels in both home and office settings.
September 2013 in “Experimental Dermatology” The document concluded that stem cells are crucial for skin repair, regeneration, and may help in developing advanced skin substitutes.
January 2011 in “Zhongguo nongye Kexue” This study successfully established a transgenic sheep fibroblast cell line expressing the spider dragline silk protein gene, laying groundwork for developing transgenic sheep with this capability in hair follicles.
October 2022 in “Experimental Dermatology” This review discusses the development of hair-on-a-chip technology for hair follicle research and alopecia treatment, reporting no new clinical results but highlighting future research directions.
9 citations
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June 2021 in “Biological reviews/Biological reviews of the Cambridge Philosophical Society” This review discusses molecular regulatory circuitry in organ regeneration, using skin regeneration examples, and reports no new experimental results; the authors propose that understanding this circuitry might aid in developing therapeutic strategies.