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    Glossary Dermal Fibroblasts

    specialized skin cells that produce collagen and aid healing

    Dermal fibroblasts are specialized cells found in the dermis, the middle layer of the skin. They play a crucial role in wound healing and the production of collagen and other extracellular matrix components, which provide structural support and elasticity to the skin.

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    Research 30 of 1000+

    1. Hair-follicle dermal papilla and sheath fibroblasts provide a supportive microenvironment for human skin regeneration 2017 · 3 citations
    2. 259 Scalp hair follicle dermal sheath fibroblasts express genes associated with promotion of skin integrity/wound healing and prevention of autoimmune responses in Recessive Dystrophic Epidermolysis Bullosa Journal of Investigative Dermatology · 2024
    3. Human hair follicle dermal papilla cell, dermal sheath cell and interstitial dermal fibroblast characteristics. PubMed · 1996 · 36 citations
    4. Human Scalp Dermal Papilla and Fibrous Sheath Cells have a different expression profile of Matrix Metalloproteinases in vitro when compared to Scalp Dermal Fibroblasts Archives of Dermatological Research · 2005 · 9 citations
    5. 022 Randomized, double-blind, placebo-controlled, single-centre, phase I safety study of intradermal injections of autologous fibroblasts isolated from the non-bulbar dermal sheath of the hair follicle to treat skin aging Journal of Investigative Dermatology · 2017
    6. Faculty Opinions recommendation of Age-related changes in female scalp dermal sheath and dermal fibroblasts: how the hair follicle environment impacts hair ageing. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2021
    7. Hair Strengthening Evaluation of Anisotropic Osmolite Solutions (Inositol + Arginine): Cross-Talk between Dermal Papilla Fibroblast and Keratinocytes of the Outer Root Sheath Using a µHair Follicle 3D Model Cosmetics · 2018
    8. Age-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging Journal of Investigative Dermatology · 2020 · 14 citations
    9. 441 Anti-melanoma gene signature in dermal sheath fibroblasts from scalp hair follicles in Recessive Dystrophic Epidermolysis Bullosa (RDEB) Journal of Investigative Dermatology · 2024
    10. Soluble factors from human hair papilla cells and dermal fibroblasts dramatically increase the clonal growth of outer root sheath cells Archives of Dermatological Research · 1993 · 62 citations
    11. 1429 Proteomic analysis of cultured dermal papilla, dermal sheath and dermal fibroblast cells from female scalp highlights alterations in the cell populations with increasing age Journal of Investigative Dermatology · 2023
    12. Effects of epidermal growth factor, fibroblast growth factor, minoxidil and hydrocortisone on growth kinetics in human hair bulb papilla cells and root sheath fibroblasts cultured in vitro Archives of Dermatological Research · 1987 · 58 citations
    13. Sex Hormones and Antiandro Growth of Dermal Papilla H ens Influence In Vitro Ce Is and Outer Root Sheath Keratinocytes of Human Hair Follicles 1993
    14. Single-Cell RNA Profiling of Human Skin Reveals Age-Related Loss of Dermal Sheath Cells and Their Contribution to a Juvenile Phenotype Frontiers in Genetics · 2022 · 37 citations
    15. Characterization of human dermal sheath cells reveals CD36-expressing perivascular cells associated with capillary blood vessel formation in hair follicles Biochemical and Biophysical Research Communications · 2019 · 16 citations
    16. Alteration of Skin Properties with Autologous Dermal Fibroblasts International Journal of Molecular Sciences · 2014 · 67 citations
    17. Dermal sheath cells contribute to postnatal hair follicle growth and cycling Journal of Dermatological Science · 2016 · 10 citations
    18. Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species European journal of histochemistry · 2009 · 6 citations
    19. 862 Defining the molecular signature of the hair follicle dermal sheath and its functional requirement for hair cycle progression during catagen Journal of Investigative Dermatology · 2017
    20. Growth kinetics of cultured dermal papilla cells and dermal sheath cells from human hair follicles Acta Academiae Medicine Militaris Tertiae · 2000
    21. Expression of mesenchymal stem cell marker CD90 on dermal sheath cells of the anagen hair follicle in canine species European Journal of Histochemistry · 2009 · 15 citations
    22. Connective tissue sheath of hair follicle is a major source of dermal type I procollagen in human scalp Journal of dermatological science · 2012 · 4 citations
    23. STUDY ON HAIR FOLLICLE FORMATION INDUED BY DERAMAL PAPILLA CELL Chinese Journal of Reparative and Reconstructive Surgery · 2003
    24. Multifaceted role of hair follicle dermal cells in bioengineered skins 2016 · 33 citations
    25. The central role of fibroblasts in androgenic alopecia: A systematic umbrella review Cell Transplantation · 2026
    26. 1424 Single-cell RNA sequencing of different fibroblast populations cultured from female scalp reveals significant alterations to transciptional profiles with age 2023
    27. Expression of melanocortin receptors on cutaneous fibroblastic cells – collagen and beyond Experimental Dermatology · 2005 · 1 citations
    28. Determination of proliferation and collagen synthesis of human dermal hair papilla cells Linchuang pifuke zazhi · 2004 · 1 citations
    29. The Central Role of Fibroblasts in Androgenic Alopecia: a systematic umbrella review and meta-meta-analysis Open MIND · 2026
    30. Experimental Modulation of the Differentiated Phenotype of Keratinocytes from Epidermis and Hair Follicle Outer Root Sheath and Matrix Cells Annals of the New York Academy of Sciences · 1991 · 31 citations