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    Glossary Dermal Fibroblasts

    specialized skin cells that produce collagen and aid healing

    Dermal fibroblasts are specialized cells found in the dermis, the middle layer of the skin. They play a crucial role in wound healing and the production of collagen and other extracellular matrix components, which provide structural support and elasticity to the skin.

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    1. Distinct fibroblast lineages determine dermal architecture in skin development and repair Nature · 2013 · 1235 citations
    2. Dermal β-catenin activity in response to epidermal Wnt ligands is required for fibroblast proliferation and hair follicle initiation Development · 2012 · 207 citations
    3. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts during Wound Healing Cell stem cell · 2020 · 128 citations
    4. Scars or Regeneration?—Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses International Journal of Molecular Sciences · 2020 · 123 citations
    5. Dermal fibroblast in cutaneous development and healing Wiley Interdisciplinary Reviews-Developmental Biology · 2017 · 115 citations
    6. Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing Development · 2016 · 87 citations
    7. Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90 American Journal Of Pathology · 2016 · 47 citations
    8. Comparative secretome analysis of human follicular dermal papilla cells and fibroblasts using shotgun proteomics BMB Reports · 2012 · 44 citations
    9. CXCL12+ dermal fibroblasts promote neutrophil recruitment and host defense by recognition of IL-17 The Journal of Experimental Medicine · 2024 · 32 citations
    10. Primary cell culture and morphological characterization of canine dermal papilla cells and dermal fibroblasts Veterinary Dermatology · 2002 · 32 citations
    11. Defining the identity of mouse embryonic dermal fibroblasts Genesis · 2016 · 21 citations
    12. Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts Journal of dermatological science · 2019 · 20 citations
    13. Age-Related Changes in Female Scalp Dermal Sheath and Dermal Fibroblasts: How the Hair Follicle Environment Impacts Hair Aging Journal of Investigative Dermatology · 2020 · 14 citations
    14. Increased expression of PD‐L1 and PD‐L2 in dermal fibroblasts from alopecia areata mice Journal of Cellular Physiology · 2017 · 13 citations
    15. Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts Journal of Investigative Dermatology · 2004 · 11 citations
    16. Fetal Fibroblast Heterogeneity Defines Dermal Architecture during Human Embryonic Skin Development Journal of Investigative Dermatology · 2025 · 8 citations
    17. The origins of skin diversity: lessons from dermal fibroblasts Development · 2022 · 6 citations
    18. Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration Applied Materials Today · 2020 · 4 citations
    19. De novo follicular regeneration of the skin by wingless int 3 and bone morphogenetic protein 2 genes introduced into dermal fibroblasts and fibroblast growth factor‐2 protein Wound Repair and Regeneration · 2009 · 4 citations
    20. T Cells Promote Distinct Transcriptional Programs of Cutaneous Inflammatory Disease in Keratinocytes and Dermal Fibroblasts Journal of Investigative Dermatology · 2025 · 2 citations
    21. Effect of Marine-Derived Saccharides on Human Skin Fibroblasts and Dermal Papilla Cells Marine Drugs · 2023 · 2 citations
    22. GDNF neurotrophic factor signaling determines the fate of dermal fibroblasts in wound‐induced hair neogenesis and skin regeneration Experimental Dermatology · 2022 · 2 citations
    23. Dermal Hedgehog Signaling in Papillary Fibroblasts: An Emerging Key Player in Skin Regeneration Journal of Investigative Dermatology · 2022 · 2 citations
    24. LB1024 Ashwagandha (Withania somnifera) seed plant exosome-like nanovesicles promote in vitro cellular regeneration of human dermal hair follicle, endothelial and fibroblast cells 2022 · 1 citations
    25. Dermal fibroblasts in the focus of modern cosmetology: aging and response to cosmetic procedures: A review Consilium Medicum · 2024
    26. MiR-23b and miR-133 cotarget TGFβ2/NOTCH1 in dermal fibroblasts and affect hair follicle development in sheep Research Square (Research Square) · 2023
    27. O21 Single-cell RNA sequencing and proteomic analysis of dermal fibroblasts cultured from female scalp identifies significant alterations in cell populations with age 2023
    28. Dermal fibroblasts: the terminology, heterogeneity of subpopulations and common properties Morphologia · 2021
    29. Decision letter: Role of distinct fibroblast lineages and immune cells in dermal repair following UV radiation-induced tissue damage 2021
    30. 467 Novel selective phosphodiesterase inhibitors promote the adipogenic function of dermal fibroblasts: Implication to treat hair loss Journal of Investigative Dermatology · 2021