Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This article reviews the regulation and roles of spermidine/spermine-N(1)-acetyltransferase (SSAT) in polyamine metabolism and its potential as a target in cancer and other diseases, without reporting new experimental results.

This study identifies SOX9 as a critical downstream effector of ERG in TMPRSS2:ERG fusion-positive prostate cancer, indicating its role in tumor invasion and growth.

This paper reviews the role of androgens in human skin function and the challenges in developing treatments for androgen-associated disorders, reporting no new experimental results.

This review discusses the role of Foxc1 and type XVII collagen in hair follicle stem cell quiescence and aging, identifying mechanisms that relate to hair thinning and hair loss, and reports no new results.

In this study, the researchers developed an in vitro model that maintains human hair follicles to grow at in vivo rates and observed that factors like EGF and IGF-I influence hair follicle growth and catagen entry.

This study found that high-dose Cyclosporin A in rats led to significant functional and structural changes, including liver, kidney, and immune system alterations, along with behavioral and hematological effects.

This study found that overexpression of the enzyme SSAT in a mouse model significantly reduced prostate tumor size and progression, suggesting it could be a promising strategy against prostate cancer.

This study found that antibiotic-induced gut dysbiosis, particularly overgrowth of Lactobacillus murinus, can lead to hair loss in mice by depleting biotin.

This review discusses the roles of interferon-γ and PPAR-γ-mediated signalling in scarring alopecia, suggesting these pathways as potential therapeutic targets, but it reports no new empirical results.

In this review, the authors explored the diverse roles of fibroblasts in wound healing, suggesting that understanding their complexity could lead to better insights into wound pathologies and the development of new treatments.

This review discusses the unique features of dermal white adipose tissue, its interaction with hair follicles, and its role in skin physiology, reporting no new experimental findings.

This review examines the roles of macrophages and Langerhans cells in skin homeostasis and suggests that understanding these functions can aid in developing therapies for skin and hair regeneration, but it reports no new research findings.

This study suggests that CD8+ cytotoxic T lymphocytes play a crucial role in the development of alopecia areata, based on observations in rodent models that mimic human autoimmune disease.

In a study on muscle regeneration in mice, researchers found that platelet-secreted CXCL7 is crucial for recruiting neutrophils to injury sites, aiding early muscle repair and optimal regrowth, suggesting potential therapeutic uses for boosting muscle healing.

This review discusses the lack of specific micronutrient supplementation recommendations for hair loss in patients on long-term parenteral nutrition and reports no new clinical results.

In this study, PINCH-1 gene loss in mouse epidermis led to detachment from the basement membrane, thickened skin, and hair loss, with findings suggesting PINCH-1 plays a role in keratinocyte adhesion through both ILK and EPLIN pathways.

Revertant cell therapy shows promise for treating type XVII collagen deficiency, but better cell selection methods are needed.

This study found that constitutively active Stat3 in transgenic mice led to reduced keratinocyte stem cell populations in hair follicles, altering stem/progenitor cell dynamics and homeostasis.

This study found that treating neonatal mice with the neurotoxin 6-OHDA resulted in temporary hair loss and thinner skin compared to control mice, linking sympathetic neurons to hair growth and skin thickness.

This article discusses the effectiveness of fat transfer for facial rejuvenation across all ethnicities, emphasizing its potential as both a primary method and a complement to traditional techniques, but reports no new clinical findings.

This study found that S-Methylmethionine sulfonium (SMMS) enhances cell survival and reduces damage from UVB irradiation in skin cells, suggesting its potential as a cosmetic ingredient for UV protection.

In this study, transgenic mice overexpressing the SSAT gene were highly sensitive to polyamine analogues, leading to severe liver changes and high mortality rates after treatment.

This study observed that human anagen hair follicles can grow in vitro when maintained serum-free, with possible implications for understanding hair follicle growth mechanisms.

This study found that daily supplementation with 10 to 20 mg of calcium pantothenate led to complete recovery and significant improvement in appetite and growth in young pigs with pantothenic acid deficiency.

This study found that PBX1 overexpression reduces hair follicle-derived mesenchymal stem cell senescence and apoptosis by interacting with SIRT1 and PARP1, highlighting a potential mechanism for addressing aging-related diseases.

This case report describes two acute hair-related manifestations, alopecia areata and Marie Antoinette syndrome, observed in the same patient following COVID-19 infection.

Albert Kligman, known for his dermatology research and the discovery of tretinoin, was a significant figure in hair science but faced controversy for inmate experiments.

This report suggests that TCDD may alter human epidermal stem cell populations by upregulating c-Myc, potentially leading to increased stem cell turnover during chloracne development.

In this study, researchers found that disrupting EGFR signaling in mice led to increased inflammation and hair follicle damage but that inhibiting the JAK-STAT1 pathway could restore hair growth and skin function.

This study highlights that although mogamulizumab is highly effective for treating mycosis fungoides and Sézary syndrome, it frequently causes a variety of rashes as side effects.