This study identified 92 novel regulators of melanogenesis, highlighting Aldehyde dehydrogenase 1A1 as a potential target for developing new treatments for hyperpigmentation disorders like melasma.
This study identified ALDH1A1 as a regulator of melanogenesis and suggests its inhibition, through agents like cyanamide, may be a promising therapeutic approach for treating hyperpigmentation disorders such as melasma.
November 2014 in “Springer eBooks” Using a patient's own tissue for browlifting can improve both the position and fullness of the brow for a longer-lasting rejuvenation.
May 2013 in “CRC Press eBooks” This review discusses laser hair removal, its scientific background, and treatment optimization but reports no new experimental findings.
Jockeys using diuretics without potassium supplements can face health problems.
232 citations
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October 2015 in “International journal of molecular sciences” This review discusses the role of epidermal and other adult stem cells in skin repair, focusing on their potential therapeutic applications for non-healing wounds and other skin disorders, but reports no new research results.
114 citations
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June 2000 in “Endocrinology” In this study, the researchers found that alopecia in VDR null mice is likely due to issues with hair cycle initiation rather than defects in keratinocyte proliferation or differentiation.
59 citations
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April 2016 in “Cell Reports” This study demonstrated that EdnrB signaling promotes melanocyte stem cell proliferation and differentiation, enhancing hair and epidermal melanocyte regeneration, especially under conditions of active Wnt signaling.
53 citations
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October 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that cyclophosphamide induced significant keratinocyte apoptosis in anagen hair follicles of mice, while topical calcitriol-analogs reduced this apoptosis, suggesting a protective effect against chemotherapy-induced alopecia.
29 citations
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June 2000 in “Endocrinology” This study suggests that alopecia in vitamin D receptor null mice is due to impaired initiation of the hair cycle rather than defects in keratinocyte proliferation or differentiation.
22 citations
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April 2023 in “The Journal of Cell Biology” In this study, researchers found that coordinated intercellular Ca2+ signaling among basal stem cells in mice is crucial for cell cycle progression and tissue-wide communication during epidermal regeneration.
16 citations
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July 2018 in “Experimental Dermatology” This study suggests that the transcription factor Gata6 plays a role in maintaining the structure of the upper hair follicle and may be implicated in conditions marked by its abnormal expansion, such as acne or cystic diseases.
16 citations
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August 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that MED1 plays a role in maintaining keratinocyte quiescence and hair follicle stem cell populations, as its absence in mice led to increased keratinocyte proliferation and reduced stem cell numbers.
7 citations
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December 2017 in “Anais da Academia Brasileira de Ciências” This study found that 6-Gingerol significantly suppressed hair growth in mice by reducing hair follicle number and length, potentially through increased expression of MMP2 and MMP9.
3 citations
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October 2023 in “Military Medical Research/Military medical research” This review explores the crucial role of regulatory T cells in skin wound healing, emphasizing their involvement in balancing immune responses and promoting regeneration. It also discusses Tregs' operations in fibrosis, keloidosis, and scarring, suggesting a potential avenue for novel treatments.
1 citations
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October 2022 in “Scientific reports” This study found that nestin-expressing progenitor cells, capable of becoming ORS keratinocytes, are present in both developing and adult mouse hair follicles.
1 citations
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June 2017 in “Nature Reviews Immunology” Immune cells called Treg cells are essential for hair growth and regeneration.
1 citations
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April 2016 in “Journal of Investigative Dermatology” Zinc deficiency causes reversible hair loss by disrupting hair growth and stem cell function.
1 citations
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August 1984 in “Therapeutische Umschau. Revue thérapeutique” This article reviews treatments for facial hypertrichosis and hirsutism and reports no new clinical findings; the authors highlight the potential of laser and pulsed flash-light systems for permanent hair removal.
July 2025 in “Journal of Investigative Dermatology” Hhip-Cre effectively targets dermal papilla cells for gene manipulation in hair biology.
November 2023 in “Nature Communications” This study reported that depleting the pro-apoptotic protein Bax in hair follicle stem cells enables these cells to kill nearby viable cells by sequestering TNFα, which increases the stem cell pool and accelerates tissue regeneration, suggesting potential implications for therapies targeting tissue repair and cancer.
April 2023 in “Journal of Investigative Dermatology” This study found that mitochondrial dysfunction in the epidermis contributes to aging-related changes in hair follicles among mice, with aged mice showing reduced hair density and delayed regrowth, suggesting that maintaining mitochondrial function may help prevent age-related organ decline.
February 2023 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that in adult mouse skin, somatosensory axon plasticity is highly dynamic and influenced by epithelial-neural crosstalk and intrinsic neural mechanisms.
January 2022 in “Social Science Research Network” This study found that activating both PKM2 and Wnt/β-catenin signaling enhanced hair re-growth and HFSCs proliferation in mice, suggesting a potential treatment strategy for alopecia.
January 2010 in “Journal of Yangzhou University” In this study, sulfated fucans promoted hair growth in mice by advancing hair follicles to anagen IV and delaying their regression to catagen, possibly through VEGF and HGF effects.
May 2002 in “Therapeutische Umschau” This article reviews existing treatments for hypertrichosis and hirsutism, noting that while eflornithine is a promising new option, the efficacy of systemic antiandrogens remains unproven in modern clinical studies.
1 citations
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August 2010 in “Journal of dermatology” This study found that photoepilation using intense pulsed light significantly reduced hair growth parameters, and phototrichograms may offer an objective method to evaluate its effectiveness.
May 2013 in “Optometry and vision science” This abstract provides summaries of multiple clinical reports on topics like macular holes with posterior uveal melanoma, hemolacria, trichotillomania management with bimatoprost, Demodex identification methods, and psychological factors in contact lens discomfort, but reports no new research findings.
385 citations
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November 1990 in “Journal of Cell Science” This study successfully grew and maintained human hair follicles in vitro, noting that TGF-β1 negatively affects growth, while EGF replicates hair-removal effects seen in animals.
369 citations
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June 2013 in “Biochimie” This review discusses the potential benefits of myo-inositol supplementation for insulin resistance-related disorders and diabetic complications, but reports no new clinical results.