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GlossaryKeratin 14

protein in skin's basal layer providing structural support

Keratin 14 (KRT14) is a type of protein found in the skin, specifically in the basal layer of the epidermis. It plays a crucial role in providing structural support and resilience to skin cells. Mutations in the KRT14 gene can lead to skin disorders such as epidermolysis bullosa simplex, which causes the skin to be fragile and blister easily.

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research Induced Pluripotent Stem Cells from Human Hair Follicle Keratinocytes as a Potential Source for In Vitro Hair Follicle Cloning

November 2016

Human hair follicle cells can be turned into stem cells that may help clone hair for treating hair loss or burns.

Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

research Androgens Modulate Keratinocyte Differentiation Indirectly Through Enhancing Growth Factor Production From Dermal Fibroblasts

20 citations, January 2019 in “Journal of dermatological science”

Male hormones indirectly affect skin cell development by increasing growth factor levels from skin fibroblasts.

research Wound Healing Mechanism in Mongolian Gerbil Skin

6 citations, November 2018 in “Histochemistry and Cell Biology”

Mongolian gerbils heal wounds differently than mice, with unique protein levels and gene expression that affect skin repair.

research Desmoplastic Tricholemmoma in a Dog

4 citations, January 2017 in “Journal of veterinary medical science”

A dog had a rare skin tumor called desmoplastic tricholemmoma.

Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System That Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice

research Oil Body-Bound Oleosin-rhFGF-10: A Novel Drug Delivery System That Improves Skin Penetration to Accelerate Wound Healing and Hair Growth in Mice

11 citations, October 2017 in “International Journal of Molecular Sciences”

A new drug delivery system using oil body-bound oleosin-rhFGF-10 improves wound healing and hair growth in mice.

research Control of Hair Follicle Cell Fate by Underlying Mesenchyme Through a CSL–Wnt5a–FoxN1 Regulatory Axis

95 citations, July 2010 in “Genes & development”

Notch/CSL signaling controls hair follicle differentiation through Wnt5a and FoxN1.

research Functionally Distinct Melanocyte Populations Revealed by Reconstitution of Hair Follicles in Mice

10 citations, November 2010 in “Pigment Cell & Melanoma Research”

Only skin melanocytes, not other types, can color hair in mice.

Pilose Antler Extracts Promote Hair Growth in Androgenetic Alopecia Mice by Activating Hair Follicle Stem Cells via the AKT and Wnt Pathways

research Pilose Antler Extracts Promote Hair Growth in Androgenetic Alopecia Mice by Activating Hair Follicle Stem Cells via the AKT and Wnt Pathways

July 2024 in “Frontiers in Pharmacology”

Pilose antler extracts help hair growth by activating hair follicle stem cells.

research Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in the Mouse

March 2023

Deleting Smad4 and PTEN genes in mice causes rapid, invasive stomach cancer.

research Data from Synergistic Function of Smad4 and PTEN in Suppressing Forestomach Squamous Cell Carcinoma in Mice

March 2023

Deleting Smad4 and PTEN genes in mice causes rapid, invasive forestomach cancer.

research Observations Suggesting a Contribution of Altered Dermal Papilla Mitochondrial Function to Androgenetic Alopecia

4 citations, February 2022 in “Experimental Dermatology”

Hair loss in men might be linked to changes in cell energy factories.

Induction of Dermal Fibroblasts into Dermal Papilla Cell-Like Cells in Hydrogel Microcapsules for Enhanced Hair Follicle Regeneration

research Induction of Dermal Fibroblasts into Dermal Papilla Cell-Like Cells in Hydrogel Microcapsules for Enhanced Hair Follicle Regeneration

4 citations, August 2020 in “Applied Materials Today”

Hydrogel microcapsules help create cells that boost hair growth.

research In Vivo Reprogramming of Wound-Resident Cells Generates Skin with Hair

March 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Scientists can now create skin with hair by reprogramming cells in wounds.

research Hair Follicle Stem Cell Progeny Heal Blisters While Pausing Skin Development

April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Skin healing from blisters can delay hair growth as stem cells focus on repairing skin over developing hair.

research Characterization of Xenobiotic Metabolizing Enzymes of a Reconstructed Human Epidermal Model from Adult Hair Follicles

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

research Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

115 citations, August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

Thyroid hormones help hair grow, reduce hair loss, and increase hair pigment.

Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

research Overexpression of Bcl-2 Protects from Ultraviolet B-Induced Apoptosis but Promotes Hair Follicle Regression and Chemotherapy-Induced Alopecia

47 citations, April 2000 in “The American journal of pathology”

Bcl-2 overexpression protects against UVB damage but worsens hair loss from chemotherapy.

research Stimulatory Effect of Brazilian Propolis on Hair Growth Through Proliferation of Keratinocytes in Mice

18 citations, November 2014 in “Journal of Agricultural and Food Chemistry”

Brazilian propolis was found to speed up hair growth in mice by increasing the growth of skin cells that form hair.

Skin Regeneration with Conical and Hair Follicle Structure of Deep Second-Degree Scalding Injuries via Combined Expression of the EPO Receptor and Beta Common Receptor by Local Subcutaneous Injection of Nanosized rhEPO

research Skin Regeneration with Conical and Hair Follicle Structure of Deep Second-Degree Scalding Injuries via Combined Expression of the EPO Receptor and Beta Common Receptor by Local Subcutaneous Injection of Nanosized rhEPO

15 citations, March 2012 in “International journal of nanomedicine”

Local injections of nanosized rhEPO can speed up skin healing and improve quality after deep second-degree burns.

research Hair Follicle Mesenchymal Stem Cell Exosomal LncRNA H19 Inhibited NLRP3 Pyroptosis to Promote Diabetic Mouse Skin Wound Healing

13 citations, February 2023 in “Aging”

A substance from hair follicle stem cells helps heal skin wounds in diabetic mice by promoting cell growth and preventing cell death.

research In Vitro Assembly Properties of Human Type I and II Hair Keratins

12 citations, January 2014 in “Cell structure and function”

Different combinations of human hair keratins affect how hair fibers form.

ERK1/2 Pathway Involvement in Enhancement of Fatty Acids from Phaeodactylum Tricornutum Extract on Hair Follicle Cell Proliferation

research ERK1/2 Pathway Involvement in Enhancement of Fatty Acids from Phaeodactylum Tricornutum Extract on Hair Follicle Cell Proliferation

2 citations, October 2020 in “BioMed Research International”

Phaeodactylum tricornutum extract helps hair follicle cells grow by activating the ERK1/2 pathway.

M-CSF-Stimulated CD11b+ Myeloid Cells Induce Alopecia Areata in C3H/HeJ Mice

research Multifunctional Zinc-Doped Hollow Mesoporous Silica/Polycaprolactone Electrospun Membranes with Enhanced Hair Follicle Regeneration and Antibacterial Activity for Wound Healing

76 citations, January 2019 in “Nanoscale”

Created material boosts hair growth and kills bacteria for wound healing.

research A New Path in Defining Light Parameters for Hair Growth: Discovery and Modulation of Photoreceptors in Human Hair Follicle

70 citations, April 2017 in “Lasers in surgery and medicine”

Blue light promotes hair growth by interacting with specific receptors in hair follicles.