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    Glossary Cytokeratins

    fibrous proteins providing structural support in epithelial cells

    Cytokeratins, also known as keratin proteins or CKs, are a group of fibrous structural proteins that form the intermediate filaments in epithelial cells. They provide mechanical support and help maintain the integrity of cells and tissues. In a clinical context, cytokeratins are often used as biomarkers in the diagnosis and study of various cancers, as their expression patterns can indicate the type and origin of a tumor.

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    1. Cytokeratin expression of apocrine and eccrine poromas with special reference to its expression in cuticular cells Journal of Cutaneous Pathology · 2000 · 37 citations
    2. Androgens modulate keratinocyte differentiation indirectly through enhancing growth factor production from dermal fibroblasts Journal of dermatological science · 2019 · 20 citations
    3. An Exploratory In Vivo Study on the Effect of Annurca Apple Extract on Hair Growth in Mice Current Issues in Molecular Biology · 2022 · 1 citations
    4. Lentinula edodes (Shiitake) extract as a vitamin D receptor activator to enhance skin adaptogenic responses Scientific Reports · 2026
    5. A Case of Trichoblastoma Linchuang pifuke zazhi · 2003
    6. [An immunohistochemical study on cell differentiation in the outer root sheath of the normal human anagen hair follicles with antikeratin monoclonal antibodies]. PubMed · 1990 · 6 citations
    7. Decellularized Wharton's jelly matrix as a three dimensional scaffold for wound healing and hair regeneration applications KU ScholarWorks (The University of Kansas) · 2016
    8. Cytokeratin expression in trichoblastic fibroma (small nodular type trichoblastoma), trichoepithelioma and basal cell carcinoma British Journal of Dermatology · 1999 · 87 citations
    9. Stem cell markers (cytokeratin 15, CD34 and nestin) in primary scarring and nonscarring alopecia British Journal of Dermatology · 2009 · 54 citations
    10. Cytokeratin 15 expression in central, centrifugal, cicatricial alopecia: new observations in normal and diseased hair follicles Journal of Cutaneous Pathology · 2011 · 14 citations
    11. Keratinisation status and cytokeratins of the human Meibomian gland epithelium Acta Ophthalmologica · 2009 · 5 citations
    12. Cytokeratin 15 expression in trichoepitheliomas and a subset of basal cell carcinomas suggests they originate from hair follicle stem cells Journal of Cutaneous Pathology · 1999 · 133 citations
    13. Characterization of a 190-Kilobase Pair Domain of Human Type I Hair Keratin Genes 1998 · 74 citations
    14. Thyrotropin-Releasing Hormone (TRH) Promotes Wound Re-Epithelialisation in Frog and Human Skin PLOS ONE · 2013 · 46 citations
    15. Immunohistochemical expression of cytokeratin 15, cytokeratin 19, follistatin, and Bmi-1 in basal cell carcinoma International Journal of Dermatology · 2015 · 10 citations
    16. Desmoplastic tricholemmoma in a dog Journal of veterinary medical science · 2017 · 4 citations
    17. <i>De novo</i> filament formation by human hair keratins K85 and K35 follows a filament development pattern distinct from cytokeratin filament networks FEBS open bio · 2021 · 2 citations
    18. Establishment of dermal sheath cell line from Cashmere goat and characterizing cytokeratin 13 as its novel biomarker Biotechnology Letters · 2018 · 2 citations
    19. 268 Use of ultra-fast one-step CK5 ihc for identifying bcc and scc during mohs surgery Journal of Investigative Dermatology · 2017 · 1 citations
    20. Epithelial expression of cytokeratins 15 and 19 in vitiligo Journal of Cosmetic Dermatology · 2016 · 1 citations
    21. Follicular Stem Cells in Androgenetic Alopecia Journal of Cytology and Histology · 2015
    22. Are the Meibomian glands “hair follicles without a hair shaft” ? Acta Ophthalmologica · 2010 · 2 citations
    23. Ha 1 and Ha 4-Trichocytic Cytokeratin Subunits Expression during Hair Development in Rat Embryonal Skin Nihon Chikusan Gakkaiho · 1993
    24. Immunohistochemical dissection of cystic panfolliculoma focusing on the expression of multiple hair follicle lineage markers with an insight into the pathogenesis Journal of Cutaneous Pathology · 2017 · 7 citations
    25. New aspects of galectin functionality in nuclei of cultured bone marrow stromal and epidermal cells: biotinylated galectins as tool to detect specific binding sites Biology of the Cell · 2003 · 89 citations
    26. Damage of hair follicle stem cells and alteration of keratin expression in external radiation-induced acute alopecia International Journal of Molecular Medicine · 2012 · 28 citations
    27. Overexpression of human keratin 16 produces a distinct skin phenotype in transgenic mouse skin Biochemistry and Cell Biology · 1995 · 25 citations
    28. <i>Brassica oleracea</i> extract, glucosinlates, and sulforaphane promote hair growth in vitro and ex vivo Journal of Cosmetic Dermatology · 2021 · 2 citations
    29. Hair Transplantation The Journal of Dermatologic Surgery and Oncology · 1994 · 2 citations
    30. Keratinic amyloid deposition in canine hair follicle tumors Veterinary pathology · 2022 · 1 citations