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Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

The document concludes that sex hormones are crucial for mammalian reproduction, health, and behavior, and require more research for therapeutic use.

Caffeine can protect scalp hair follicles from damage caused by UV radiation.

Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Air pollution worsens skin diseases and aging by causing inflammation and oxidative stress.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

PGD2 stops hair growth and is higher in bald men with AGA.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

The document concludes that proper diagnosis and a multidisciplinary approach are crucial for managing Congenital Adrenal Hyperplasia effectively.

The sebaceous gland has more roles than just producing sebum and contributing to acne, and new research could lead to better skin disease treatments.

TCDD speeds up skin barrier formation by increasing certain gene expressions.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

Impaired androgen production in 46,XY DSDs causes ambiguous genitalia and requires long-term care.

Certain drugs that block specific enzymes can help treat prostate diseases.

Metformin has limited effectiveness for improving PCOS symptoms and lacks clear benefits, needing more research to confirm its efficacy.

Certain microRNAs in the fluid around eggs are linked to Polycystic Ovary Syndrome and may help diagnose it.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

Low doses of mixed chemicals cause permanent reproductive malformations in male rats.

The research suggests that the global distribution of PCOS is likely due to historical human migration and that genes affecting PCOS may have different impacts on males and females.

Melatonin improves cashmere goat hair growth and quality by increasing antioxidants and reducing cell death.

Human skin produces sex hormones like estrogen and testosterone, influenced by ARO and StAR, which may affect skin elasticity and hair growth.

Non-classic congenital adrenal hyperplasia is a common disorder causing symptoms like acne and infertility, and it's managed based on symptoms, not just test results. Treatment can improve fertility and reduce miscarriage risk.

Quercetin may help with PCOS symptoms, but more research is needed.

Young girls whose mothers have PCOS may have higher activity of a specific enzyme that could lead to developing PCOS later.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Adrenal disorders can cause lasting brain and behavior issues in children.