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    Glossary CYP17A1

    enzyme crucial for steroid hormone production

    CYP17A1, also known as Cytochrome P450 17A1, is an enzyme that plays a crucial role in the production of steroid hormones. It is involved in the conversion of pregnenolone and progesterone into their 17-alpha-hydroxylated products, which are precursors for androgens and estrogens. This enzyme is essential for the synthesis of hormones that regulate various bodily functions, including metabolism, immune response, and sexual development.

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    Research 30 of 462

    1. Intratumoral <i>De Novo</i> Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors Cancer research · 2011 · 402 citations
    2. The significance of CYP11A1 expression in skin physiology and pathology Molecular and Cellular Endocrinology · 2021 · 91 citations
    3. Investigation of variants of the aromatase gene (CYP19A1) in female pattern hair loss British Journal of Dermatology · 2011 · 15 citations
    4. The Associations of Androgen-Related Genes CYP21A2 and CYP19A1 with Severe Acne Vulgaris in Patients from Southwest China Clinical Cosmetic and Investigational Dermatology · 2021 · 10 citations
    5. Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population Dermatology · 2015 · 7 citations
    6. MitoQ upregulates CYP19A1 to protect dermal papilla cells from DHT-induced mitochondrial dysfunction and apoptosis in androgenetic alopecia Biochemical Pharmacology · 2026
    7. Coconut oil works as a gonadal feedback testosterone booster and increases pituitary aromatase (cyp19a1b) expression levels in fugu (Takifugu rubripes) Aquaculture · 2025
    8. Exploring the role of CYP19A1 single nucleotide polymorphisms in the pathogenesis of female pattern hair loss Egyptian Journal of Dermatology and Venerology · 2025
    9. MitoQ enhances CYP19A1 expression to stimulate WNT/β-catenin signaling pathway for promoting hair growth in androgenetic alopecia European Journal of Pharmacology · 2024
    10. The role of CYP19A1 and ESR2 gene polymorphisms in female androgenetic alopecia in the Polish population Postepy Dermatologii I Alergologii · 2021
    11. Steroidogenesis of the testis – new genes and pathways Annales d'endocrinologie · 2014 · 70 citations
    12. Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts The Journal of Steroid Biochemistry and Molecular Biology · 2009 · 57 citations
    13. Gene variants associated with acne vulgaris presentation and severity: a systematic review and meta-analysis BMC Medical Genomics · 2021 · 47 citations
    14. Genetic Variants Associated with Hyperandrogenemia in PCOS Pathophysiology Genetics research international · 2018 · 29 citations
    15. Inhibition of 17α-hydroxylase/C17,20 lyase reduces gating deficits consequent to dopaminergic activation Psychoneuroendocrinology · 2013 · 19 citations
    16. Clinical-exome sequencing unveils the genetic landscape of polycystic ovarian syndrome (PCOS) focusing on lean and obese phenotypes: implications for cost-effective diagnosis and personalized treatment Scientific Reports · 2024 · 13 citations
    17. Endocrine systems of the skin Postepy Dermatologii I Alergologii · 2019 · 9 citations
    18. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro The Journal of Steroid Biochemistry and Molecular Biology · 2019 · 7 citations
    19. Effect of <i>Eurycoma longifolia</i> Extract on Testosterone Synthesis in TM3 Leydig Cells under Oxidative Stress 2022 · 1 citations
    20. Study on the mechanism that SNPs related to sex hormone metabolism regulate the imbalance of sex hormones and lead to BPH in rats 2025
    21. Identification of Potential Cytochrome p450c 17 Alpha Inhibitors for the Treatment of PCOS via Scaffold Hopping and Fragment-Based De-Novo Drug Design 2024
    22. New Target for Minoxidil in the Treatment of Androgenetic Alopecia Drug Design Development and Therapy · 2023
    23. Steroidogenesis in steroid related cancers University of Birmingham Institutional Research Archive (University of Birmingham) · 2016
    24. Association of Cyp11a Gene with Polycystic Ovarian Syndrome Patients in Lahore, Pakistan Pakistan Journal of Health Sciences · 2025
    25. Clinical-Exome Sequencing Unveils the Genetic Landscape of Polycystic Ovarian Syndrome (PCOS) Focusing on Lean and Obese Phenotypes: Implications for Cost-Effective Diagnosis and Personalized Treatment Research Square (Research Square) · 2024
    26. Genetics and Epigenetics of Polycystic Ovary Syndrome IntechOpen eBooks · 2023
    27. Gene-wide association study between the aromatase gene (<i>CYP19A1</i>) and female pattern hair loss British Journal of Dermatology · 2009 · 77 citations
    28. Studying the genetic predisposing factors in the pathogenesis of acne vulgaris Human Immunology · 2011 · 39 citations
    29. Aromatase deficiency in a male patient - Case report and review of the literature. Bone · 2016 · 36 citations
    30. Does maternal exposure to artificial food coloring additives increase oxidative stress in the skin of rats? Human & Experimental Toxicology · 2016 · 13 citations