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    Glossary CYP11A1

    enzyme converting cholesterol to pregnenolone, initiating steroid hormone production

    CYP11A1, also known as Cytochrome P450 Family 11 Subfamily A Member 1 or P450scc, is an enzyme crucial for the production of steroid hormones. It catalyzes the conversion of cholesterol to pregnenolone, the first step in the biosynthesis of all steroid hormones, which are vital for various bodily functions including stress response, immune function, and regulation of inflammation.

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    Research 30 of 437

    1. Intratumoral <i>De Novo</i> Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors Cancer research · 2011 · 402 citations
    2. The significance of CYP11A1 expression in skin physiology and pathology Molecular and Cellular Endocrinology · 2021 · 91 citations
    3. Association of Cyp11a Gene with Polycystic Ovarian Syndrome Patients in Lahore, Pakistan Pakistan Journal of Health Sciences · 2025
    4. Investigation of variants of the aromatase gene (CYP19A1) in female pattern hair loss British Journal of Dermatology · 2011 · 15 citations
    5. The Associations of Androgen-Related Genes CYP21A2 and CYP19A1 with Severe Acne Vulgaris in Patients from Southwest China Clinical Cosmetic and Investigational Dermatology · 2021 · 10 citations
    6. Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population Dermatology · 2015 · 7 citations
    7. MitoQ upregulates CYP19A1 to protect dermal papilla cells from DHT-induced mitochondrial dysfunction and apoptosis in androgenetic alopecia Biochemical Pharmacology · 2026
    8. Coconut oil works as a gonadal feedback testosterone booster and increases pituitary aromatase (cyp19a1b) expression levels in fugu (Takifugu rubripes) Aquaculture · 2025
    9. Exploring the role of CYP19A1 single nucleotide polymorphisms in the pathogenesis of female pattern hair loss Egyptian Journal of Dermatology and Venerology · 2025
    10. MitoQ enhances CYP19A1 expression to stimulate WNT/β-catenin signaling pathway for promoting hair growth in androgenetic alopecia European Journal of Pharmacology · 2024
    11. Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation Hormones · 2016
    12. The role of CYP19A1 and ESR2 gene polymorphisms in female androgenetic alopecia in the Polish population Postepy Dermatologii I Alergologii · 2021
    13. Steroidogenesis of the testis – new genes and pathways Annales d'endocrinologie · 2014 · 70 citations
    14. Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts The Journal of Steroid Biochemistry and Molecular Biology · 2009 · 57 citations
    15. Genetic Variants Associated with Hyperandrogenemia in PCOS Pathophysiology Genetics research international · 2018 · 29 citations
    16. Clinical-exome sequencing unveils the genetic landscape of polycystic ovarian syndrome (PCOS) focusing on lean and obese phenotypes: implications for cost-effective diagnosis and personalized treatment Scientific Reports · 2024 · 13 citations
    17. Endocrine systems of the skin Postepy Dermatologii I Alergologii · 2019 · 9 citations
    18. Acquired 11β-hydroxylase Deficiency by Inhaled Etomidate and its Analogues: A Mimic of Congenital Adrenal Hyperplasia JCEM Case Reports · 2024 · 2 citations
    19. Genetics and Epigenetics of Polycystic Ovary Syndrome IntechOpen eBooks · 2023
    20. A review of hyperandrogenism state in polycystic ovarian syndrome International journal of reproduction, contraception, obstetrics and gynecology · 2023
    21. New Target for Minoxidil in the Treatment of Androgenetic Alopecia Drug Design Development and Therapy · 2023
    22. Gene-wide association study between the aromatase gene (<i>CYP19A1</i>) and female pattern hair loss British Journal of Dermatology · 2009 · 77 citations
    23. Gene variants associated with acne vulgaris presentation and severity: a systematic review and meta-analysis BMC Medical Genomics · 2021 · 47 citations
    24. In Search of New Therapeutics—Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond International Journal of Molecular Sciences · 2020 · 44 citations
    25. Studying the genetic predisposing factors in the pathogenesis of acne vulgaris Human Immunology · 2011 · 39 citations
    26. Aromatase deficiency in a male patient - Case report and review of the literature. Bone · 2016 · 36 citations
    27. Inhibition of 17α-hydroxylase/C17,20 lyase reduces gating deficits consequent to dopaminergic activation Psychoneuroendocrinology · 2013 · 19 citations
    28. Does maternal exposure to artificial food coloring additives increase oxidative stress in the skin of rats? Human & Experimental Toxicology · 2016 · 13 citations
    29. 11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro The Journal of Steroid Biochemistry and Molecular Biology · 2019 · 7 citations
    30. Early onset female pattern hair loss: a case–control study for analyzing clinical features and genetic variants Journal of Dermatological Science · 2022 · 3 citations