272 citations
,
September 2001 in “Journal of Biological Chemistry” This study cataloged human type II hair keratins, detailing their expression and differentiation roles in hair follicles and comparing them with type I keratins to explore keratin-pairing principles.
126 citations
,
January 1987 in “Current topics in developmental biology/Current Topics in Developmental Biology” Different keratin proteins are expressed in various epithelial cells at different stages, affecting cell structure and function.
40 citations
,
November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that the S100A3 gene is exclusively expressed in hair follicle cells differentiating into hair shaft components in mice, suggesting its important role in hair formation.
34 citations
,
August 1966 in “Experimental cell research” This study examined developing hair cortex with electron microscopy and found that keratin fibrils form between specific regions in hair follicles and aggregate into twisted cables.
18 citations
,
February 1992 in “Molecular Biology Reports” This study identified and characterized a murine type II hair keratin, demonstrating its presence in specific cells of hair and tongue tissues.
61 citations
,
February 1997 in “Differentiation” Hair differentiation starts earlier than thought, involving multiple type-II keratins.
49 citations
,
July 2006 in “British Journal of Dermatology” This study observed that calcifying epithelioma of Malherbe is composed of tumor cells that differentiate into both hair cortex and outer root sheath, supporting its hair follicle origin.
40 citations
,
March 2017 in “The journal of investigative dermatology/Journal of investigative dermatology” This study visualized mitochondrial metabolism in cultured bovine hair follicles and plucked human hairs, finding that ROS and mitochondrial polarization correlate in specific hair follicle regions, particularly near keratin deposition sites.
35 citations
,
May 2022 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism” This review discusses the current understanding of androgen biosynthesis, mechanisms of action, and their roles in human biology, as well as related congenital and acquired disorders, but it reports no new research findings.
34 citations
,
December 1984 in “Journal of Cutaneous Pathology” This study observed that the thinning and structural abnormalities in monilethrix-affected hair occur at the internodes due to possible periodic dysfunction of the hair matrix, particularly in the cortex.
10 citations
,
December 2001 in “PubMed” This research suggests that both proposed pathways into hair fibers for molecule penetration are valid and complementary, with all fiber structures acting as potential routes for delivering materials.
8 citations
,
January 2016 in “Journal of fiber science and technology” This study found that cysteic acid generation during hair bleaching is diffusion-controlled, increasing with the square root of bleaching time, in both cuticles and cortex of human hair fibers.
February 2023 in “Mağallaẗ Tikrīt li-l-ʻulūm al-ṣirfaẗ/Tikrit journal of pure science” In this study, the researchers reported the detailed anatomical structure of horse skin, including the composition and organization of the epidermis, dermis, and associated glands and follicles.
January 2023 in “Open Life Sciences” This study found that VEGFR-2 activation may play a role in hair follicle differentiation, proliferation, and apoptosis by co-expressing with several key proteins in normal human scalp skin.
This study found that hair germ and epidermal basal cells differ in keratin expressions in rat hair tissues, with hair-specific keratins appearing after the differentiation of each layer.
August 1989 in “Proceedings ... annual meeting, Electron Microscopy Society of America/Proceedings, annual meeting, Electron Microscopy Society of America” This microscopy study examined the non-keratinous regions of human hair fibers, revealing detailed morphology that could help understand how external influences affect hair structure.
93 citations
,
May 1990 in “The EMBO Journal” Mice with extra sheep genes had hair that fell out and regrew in cycles.
47 citations
,
June 1996 in “International Journal of Legal Medicine” This article discusses how drug molecules integrate into hair fibers, focusing on biological transport mechanisms and physicochemical factors, but reports no new experimental findings.
31 citations
,
January 2004 in “Methods in cell biology” Hair and follicle keratins differ in structure and expression, especially in cysteine content.
132 citations
,
August 2008 in “Development” This research found that Dlx3 plays a central role in hair formation and regeneration, with its absence leading to alopecia through disrupted differentiation and signaling pathways.
48 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This article reviews the genetic and protein interactions involved in hair growth, highlighting regulatory sequences, expression patterns, and potential genetic modifications, but presents no new experimental findings.
36 citations
,
January 2018 in “Scientific reports” This study observed that dietary intake of glucoraphanin during juvenile and adolescent stages prevented cognitive deficits and abnormal gene expressions in the brain of adult offspring exposed to maternal immune activation, potentially implicating centrosome-related genes in the development of psychosis.
15 citations
,
October 2004 in “Colloids and surfaces. B, Biointerfaces” This study describes the presence of holes in hair fibers, absent in hair follicles, likely forming from daily care actions and removal of extractable substances.
12 citations
,
December 1965 in “Immunology and Cell Biology” This study found that experimentally induced calcification in rat skin led to rapid and localized mineralization in hair follicles, progressing to more extensive calcification with prior hypercalcemic treatment.
This study found that increased expression of type 2 TGF-β and type II receptor was observed in the bald vertex area of hair follicles from androgenetic alopecia patients, suggesting a role in catagen induction.
1 citations
,
May 2013 in “PubMed” This study found that glycylglycine treatment improved hair softness by enhancing hair alignment and altering internal fiber properties among Japanese women with typically coarse hair.
44 citations
,
August 2010 in “The veterinary clinics of North America. Exotic animal practice” This article reviews common endocrine neoplasms in domestic ferrets and discusses diagnosis and medical treatment options, reporting no new research findings.
356 citations
,
December 1986 in “The journal of cell biology/The Journal of cell biology” This study found that specific human hair keratins are differentially expressed in the hair follicle, suggesting a shared pathway of epithelial differentiation between hair cortex and nail plate cells.
2 citations
,
September 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study demonstrated that ablation of individual somatostatin-expressing interneurons increased activity in nearby neurons of the mouse motor cortex during motor learning.
25 citations
,
April 2012 in “Acta Biomaterialia” This study observed that NSPC predominantly differentiated into neurons when exposed to serum fractions with molecules under 100 kDa, particularly with biomaterial and fibronectin, in the presence of basic fibroblast growth factor.