19 citations
,
July 1964 in “PubMed” This study observed that undifferentiated matrix cells at the base of the hair follicle differentiate into the medulla, cortex, cuticle, and inner root sheath cell types through specific morphological changes.
15 citations
,
May 2010 in “International Journal of Cosmetic Science” This review discusses new developments in understanding the structure and properties of keratin fiber cell membrane complexes, without reporting new experimental results.
6 citations
,
June 1976 in “Journal of ultrastructure research” This study identified the presence of recognizable organelles, such as lysosomes and mitochondria, in both the keratinized fiber and the hardened inner root sheath of the Romney wool follicle.
1 citations
,
October 2017 in “ecancermedicalscience” This study observed that the molecular structure of keratins in hair fibres' discrete transition zone differs in breast cancer patients, with altered lipid ester absorption bands reverting post-cancer removal.
18 citations
,
March 2009 in “Experimental Dermatology” This study suggests that pilomatricoma can differentiate towards various hair follicle structures, including hair matrix, hair cortex, follicular infundibulum, outer root sheath, and hair bulge.
109 citations
,
June 2000 in “Development” This study reports that activating Notch signaling in the hair follicle cortex of transgenic mice caused abnormal differentiation of the medulla and cuticle, highlighting potential cell-cell interactions.
6 citations
,
December 2018 in “International Journal of Cosmetic Science” This study found that a highly resistant structure, located at the interface between the cuticle and cortex of human hair, acts as a penetration barrier, which the authors propose to name the "cuticle anchored resistant base" or CARB.
55 citations
,
February 2014 in “Journal of Structural Biology” This study observed that human hair macrofibrils predominantly exhibit a double-twist architecture with varying inter-macrofibril angles, advancing insights into their structural organization and mechanical implications.
56 citations
,
January 1996 in “Journal of Forensic Sciences” This study found that rhodamine B penetrated human hair fibers more effectively from an aqueous solution compared to a methanol/ethanol solvent, with penetration depending on hair morphology.
47 citations
,
June 1994 in “Experimental Cell Research” mHa2 and mHa3 keratins have different structures and roles in mouse hair and tongue tissues.
40 citations
,
April 1999 in “Journal of Histochemistry & Cytochemistry” In this study, the researchers identified the specific subcellular localization of the protein S100A3 in the endocuticle and cortex of human hair shafts.
19 citations
,
January 2009 in “International review of cell and molecular biology” This review explains the mechanical composition and molecular interactions that determine hair's mechanical properties, without providing any new experimental findings.
18 citations
,
November 2010 in “Journal of morphology” This research examined the ultrastructure of deer hair fibers and found significant variations in diameter, cuticle thickness, and intermediate filament arrangements among different fiber types.
6 citations
,
January 1985 in “ACTA HISTOCHEMICA ET CYTOCHEMICA” This study found that epithelial components of calcifying epithelioma of Malherbe showed lectin binding and keratin staining patterns similar to normal hair follicles, with prominent Con A staining in tumor giant cells.
1 citations
,
October 2009 in “International Journal of Cosmetic Science” This study found that a newly developed keratin active ingredient effectively prevents aging damage in hair by strengthening its structure after exposure to simulated environmental stress.
March 2010 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found that both epithelial and hair keratins are expressed in beard hair medulla cells, exhibiting unique patterns and interactions distinct from other hair follicle and epithelial cells.
67 citations
,
December 2009 in “Stem Cells” This study found that β-catenin signaling increases in newly born glial cells in the cortex after traumatic brain injury in mice, suggesting potential targets for enhancing recovery through the Wnt/β-catenin pathway.
July 2016 in “Indian journal of science and technology” In this study, researchers found that neonate hairs have a distinct microstructure with no medulla and smaller hair follicles compared to adult hairs.
34 citations
,
October 1982 in “Journal of applied polymer science” This study found that the moisture content of human hair significantly influences the type of fracture under tensile loading, with low or high humidity levels leading to smooth fractures and intermediate humidity resulting in step fractures.
17 citations
,
June 2012 in “Journal of experimental zoology. Part B, Molecular and developmental evolution” This review explores theories on the evolution of hair from synapsid scales and glands, proposing mechanisms supported by comparative studies, but reports no new experimental findings.
15 citations
,
February 1999 in “The anatomical record” This study found that defective cross-linking in hair cuticles is observable in a minority of mouse hair mutants, suggesting different proteins are involved in cross-linking across cell types.
9 citations
,
February 2016 in “Anatomical Science International” Hair proteins change location and structure as hair cells mature.
6 citations
,
January 2005 in “Han-guk hyeonmigyeong hakoeji/Applied microscopy” This study found that the 16th-century mummified hair from a female mummy in Paju was remarkably well-preserved, with the hair's ultrastructural features maintained likely due to a calcium-rich surface coat.
6 citations
,
November 1984 in “Acta Dermato Venereologica” This study investigated the immunohistochemical characteristics of keratin proteins in epidermal appendages, finding variable staining patterns in different skin structures and tumor cells, which suggests differences in keratinization.
2 citations
,
July 2019 in “Cosmetics” This study identified a unique concentric double-layered structure in both Japanese and Caucasian SHINAYAKA hair, associated with improved flexibility and elasticity, and developed a succinic acid treatment to enhance these properties.
2 citations
,
November 2006 in “Pump Industry Analyst” This study found that pilomatricomas exhibit co-expression of hair keratin hHa5 and HOXC13 in lower transitional cells, but lack LEF1 and β-catenin co-expression necessary for canonical Wnt signaling pathway-controlled cortical differentiation.
1 citations
,
January 2023 in “Indian Journal of Animal Research” The researchers developed a technique for processing and staining free hair samples using paraffin embedded blocks, revealing that routine staining does not color the enucleated cuticle, while the cortex and medulla show distinct colorations when stained.
May 2022 in “Experimental dermatology” In this study, hair shafts from trichothiodystrophy patients with ERCC2 mutations revealed abnormal cuticle structures and protein imbalances compared to normal hair shafts.
August 2007 in “Microscopy and Microanalysis” Hair fibers break by cuticle cell slipping, shape changing, cuticle fraying, and surface cracking when stretched under specific conditions.
October 2024 in “BMC Genomics” This study examined the cytodifferentiation stage of hair follicle development in cashmere goats, identifying nine cell populations and key regulatory pathways, including transcription factors and keratin genes, that may influence fiber quality and inform breeding strategies.