74 citations
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July 1995 in “PubMed” This study suggests that reversible hypopigmentation in homocystinuric patients may result from tyrosinase inhibition by homocyst(e)ine, with in-vitro experiments showing copper sulfate reversing this inhibition.
22 citations
,
November 2010 in “Toxicological & Environmental Chemistry Reviews” In this study, higher concentrations of Pb, Cd, Cu, and Zn were found in the hair of smokers and users of hair dyes compared to non-smokers and those with undyed hair.
March 2026 in “Skin Appendage Disorders” This study reviewed multiple research articles and found that patients with telogen effluvium, primarily women, had significantly lower levels of serum ferritin and vitamin D compared to healthy controls, suggesting a role for trace element imbalances in hair loss.
This systematic review and meta-analysis found that patients with telogen effluvium, primarily females, exhibited significantly lower serum levels of ferritin and vitamin D compared to healthy controls, suggesting trace element imbalances play a crucial role in this type of hair loss.
July 2024 in “Vestnik dermatologii i venerologii” This study found that women with post-COVID alopecia showed a diffuse telogen effluvium pattern and distinct trace element imbalances, such as reduced copper and increased selenium levels, helping differentiate this condition from androgenetic alopecia.
This study observed significant differences in trace element hair-scalp concentrations associated with atherosclerosis in coronary and carotid disease patients, suggesting that zinc levels and lymphocyte count interactions may significantly influence cardiovascular disease development.
September 2020 in “Benha Veterinary Medical Journal” This study found that non-infectious skin conditions in sheep were associated with oxidative stress and changes in trace elements, vitamin A, and immunoglobulin levels.
January 2011 in “Nuclear Techniques” This study found that lead accumulated in the hair shafts of individuals exposed to mining environments, while iron, copper, and zinc levels remained stable, highlighting the significance of SRXRF micro-analysis for environmental health research.
19 citations
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January 2003 in “Polish Journal of Environmental Studies” This study found that women who delivered children with locomotor system malformations had significantly higher lead concentrations in their blood and hair compared to those who had healthy children.
5 citations
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December 2024 in “Journal of Cosmetic Dermatology” Vitamin D and zinc may help treat alopecia areata.
June 2024 in “Indian Journal of Veterinary Medicine” This case report describes a Salem black kid with alopecia and other symptoms, which was diagnosed with anaplasmosis due to Anaplasma ovis infection combined with copper deficiency, as confirmed by laboratory tests including blood smears and serum biochemistry.
June 2023 in “Research Square (Research Square)” This study demonstrated that dietary cupric citrate improved growth performance and nutrient utilization in broilers, while also altering their intestinal microbiota and increasing the pH in the duodenum and jejunum.
15 citations
,
September 1970 in “Journal of Animal Science” This study investigated how dietary copper affects hair pigmentation and mineral concentrations in calves, reporting on copper's influence but not providing definitive results.
7 citations
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January 2002 in “Biological Trace Element Research” This study found that children with pituitary dwarfism had higher zinc and copper hair concentrations and lower manganese concentrations compared to healthy children.
5 citations
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January 2022 in “Pesquisa Veterinária Brasileira” The study described an outbreak of copper deficiency in dairy goats and kids in Pernambuco, Brazil, leading to various clinical and reproductive issues in the animals, including enzootic ataxia in kids.
January 2026 in “CyberLeninK (CyberLeninka)” In this study, researchers found that combining advanced physiotherapy and specialized dermacosmetics in patients with androgenetic alopecia significantly improved metabolic markers, increasing serum zinc, copper, folic acid, and vitamin D levels more than standard treatments.
December 2012 in “Bulletin of Egyptian Society for Physiological Sciences” This study found that topical application of copper (II) albumin complex improved healing signs in rats with full thickness thermal burns, enhancing antioxidant, anti-inflammatory, and pain modulating effects.
52 citations
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December 1984 in “Journal of the American Geriatrics Society” This study found that serum and hair mineral concentrations, including copper and zinc, showed no differences between Alzheimer's patients and their healthy spouses, suggesting no diagnostic utility for Alzheimer's disease.
2 citations
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May 1981 in “Journal of Animal Science” The researchers concluded that while swine hair mineral content is influenced by dietary levels, the variability and interaction between minerals suggest it may not be a reliable indicator of an animal's overall mineral composition.
18 citations
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December 2010 in “Journal of Trace Elements in Medicine and Biology” This study suggests that alterations in copper metabolism may play a key role in the development of androgenetic alopecia in women, presenting potential targets for treatment strategies.
66 citations
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November 1997 in “Nutrition” This study found that while micronutrient abnormalities are common among patients receiving home parenteral nutrition, serious consequences from these abnormalities are rare.
1 citations
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August 2012 in “Journal of Emerging Trends in Engineering and Applied Sciences” This study found that smoking may lead to earlier onset of androgenetic alopecia in Nigerian subjects, potentially mediated by alterations in serum trace elements.
2 citations
,
July 2024 in “Skin Research and Technology” Copper may protect against alopecia areata, while certain inflammatory markers increase risk.
January 1997 in “Journal of agricultural medicine and community health” This study found that scalp hair from individuals with non-insulin dependent diabetes mellitus had significantly different contents of zinc, copper, lead, cadmium, and aluminum compared to controls.
This study found that PIXE microanalysis effectively detected and quantified trace element changes in hair shafts, revealing a marked decrease in copper after treatment for green hair syndrome.
15 citations
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April 2007 in “Journal of child neurology” This case report describes an 11-month-old boy with Menkes disease, highlighting symptoms such as developmental delays and poor therapeutic response due to significant brain and vascular abnormalities.
11 citations
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February 2018 in “Amino acids” This study found that homocysteine-keratin accumulation in human hair increases towards the tips, linked to copper/iron-catalyzed demethylation of methionine, and may contribute to keratin damage.
3 citations
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April 2023 in “Journal of Veterinary Internal Medicine” This study found that dogs with idiopathic epilepsy had altered hair concentrations of several trace elements, which may suggest a role in the disease's pathophysiology and indicate effects from antiseizure medications.
January 2024 in “Ageing & longevity” This study observed low levels of zinc, copper, iron, and selenium in the plasma and hair of Ukrainian adults, suggesting a need for better nutritional interventions; it highlighted higher hair zinc levels in individuals with COVID-19 history potentially due to more frequent zinc supplementation.
1 citations
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June 2007 in “Almustansiriya journal of pharmaceutical sciences/Al-Mustansiriyah journal of pharmaceutical sciences” This study found that a two-month antioxidant treatment significantly improved hair growth in patients with alopecia areata by enhancing antioxidant defenses and correcting trace metal imbalances.