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    Glossary Collagen Remodeling

    Collagen remodeling refers to the dynamic process by which collagen fibers in the extracellular matrix are broken down and re-synthesized, playing a crucial role in tissue repair and maintenance. In the context of hair loss, particularly androgenetic alopecia, collagen remodeling can affect the hair follicle's microenvironment, influencing hair growth and follicle health. Key distinguishing characteristics include the balance between collagen synthesis and degradation, which can be altered by factors such as aging, hormonal changes, and inflammation, ultimately impacting hair density and quality.

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    1. Cell-free adipose extract inhibits hypertrophic scar formation through collagen remodeling and antiangiogenesis Open Medicine · 2025
    2. Synergistic Effects of Fractional CO <sub>2</sub> Laser and Recombinant Humanized Type III Collagen (rhCol III) in Atrophic Acne Scar Treatment: Activation of MAPK Pathway and Enhanced Collagen Remodeling Dermatologic Therapy · 2025
    3. Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity Journal of Investigative Dermatology · 2000 · 42 citations
    4. Characterization of dermal type I collagen of C3H mouse at different stages of the hair cycle British Journal of Dermatology · 1999 · 15 citations
    5. Investigation of the efficacy of fish scale collagen peptide on wound healing through various administration routes Food Bioscience · 2025 · 6 citations
    6. From a stem-cell–centered to a niche-centered view: the core role of collagen networks in hair loss and hair follicle miniaturization Frontiers in Cell and Developmental Biology · 2026
    7. The human tri-peptide GHK and tissue remodeling Journal of biomaterials science. Polymer ed. · 2008 · 165 citations
    8. Matrix remodelling and MMP expression/activation are associated with hidradenitis suppurativa skin inflammation Experimental Dermatology · 2019 · 51 citations
    9. Effect of Decellularized Extracellular Matrix Bioscaffolds Derived from Fibroblasts on Skin Wound Healing and Remodeling Frontiers in bioengineering and biotechnology · 2022 · 8 citations
    10. Effects of LED radiation on the skin – what is new in recent research? Part II. In skin remodeling processes and hair growth Dermatology Review · 2015
    11. Pooled, Frozen, Gamma‐Irradiated Amniotic Fluid Enhances Histomorphological Remodelling in Hypertrophic Scars International Wound Journal · 2025
    12. Liposomal Helix aspersa Snail Mucus: A Biomacromolecular Platform for Attenuating Chronological Skin Aging Through Modulation of miR-34a-Associated Senescence and Extracellular Matrix Remodeling International Journal of Molecular Sciences · 2026
    13. Microneedle Radiofrequency Induces Extracellular Matrix Remodeling Through Fibroblast Activation: A Histological Study in a Porcine Model Lasers in Surgery and Medicine · 2025 · 3 citations
    14. Dietary Collagen Supplementation as a Strategy for Skin Health: A Narrative Review of Clinical Effects on Skin, Hair, Nails, and Wound Healing Nutrients · 2026
    15. Hair follicle micro-particle skin grafting induces scar remodeling via PI3K-AKT signaling: a randomized clinical trial npj Regenerative Medicine · 2026
    16. Biocomposite nanofiber matrices to support ECM remodeling by human dermal progenitors and enhanced wound closure Scientific Reports · 2017 · 87 citations
    17. The Role of Extracellular Vesicles in Cutaneous Remodeling and Hair Follicle Dynamics International Journal of Molecular Sciences · 2019 · 38 citations
    18. Protective Mechanism of Adipose-Derived Stem Cells in Remodelling of the Skin Stem Cell Niche During Photoaging Cellular Physiology and Biochemistry · 2018 · 13 citations
    19. Effects of ginsenoside Rb1 on hypertrophic scar remodeling in rabbit model European journal of pharmacology · 2015 · 10 citations
    20. Human Fibroblast‐Derived Matrix Hydrogel Accelerates Regenerative Wound Remodeling Through the Interactions with Macrophages Advanced science · 2024
    21. Engineering MMP9-Responsive Antioxidative Micelle-Hydrogel Dressings for Sequential Inflammatory Remodeling and Pro-Angiogenesis in Diabetic Wound Healing Precision medicine and engineering. · 2026
    22. A NIR-responsive PDA@RES core-shell nanoplatform accelerates chronic wound healing by remodeling mitochondrial homeostasis and reversing cellular senescence Nano Research · 2026
    23. <i>Col4a2-eGFP</i>mouse model reveals the molecular and functional dynamics of basement membrane remodelling in hair follicle morphogenesis bioRxiv (Cold Spring Harbor Laboratory) · 2023
    24. Current Status of Fractional Laser Resurfacing JAMA Facial Plastic Surgery · 2015 · 44 citations
    25. Effect of composite biodegradable biomaterials on wound healing in diabetes Frontiers in Bioengineering and Biotechnology · 2022 · 25 citations
    26. Moist exposed burn ointment accelerates diabetes-related wound healing by promoting re-epithelialization Frontiers in Medicine · 2023 · 24 citations
    27. Synergistic Sequential Emission of Fractional 10.600 and 1540 nm Lasers for Skin Resurfacing: An Ex Vivo Histological Evaluation Medicina · 2022 · 22 citations
    28. Dermabrasion Facial plastic surgery · 2014 · 19 citations
    29. The influence of CD26+ and CD26− fibroblasts on the regeneration of human dermo-epidermal skin substitutes Scientific Reports · 2022 · 11 citations
    30. Confocal microscopy can assess the efficacy of combined microneedling and skinbooster for striae rubrae Journal of Cosmetic and Laser Therapy · 2018 · 7 citations