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A new mutation in the human glucocorticoid receptor reduces its function and causes resistance to glucocorticoids.

Flutamide caused damage to male rat reproductive organs and may affect fertility.

Chrousos Syndrome is caused by mutations that make the body less sensitive to glucocorticoids, leading to various symptoms and requiring high-dose treatment.

Mutations in the glucocorticoid receptor gene cause reduced sensitivity to glucocorticoids and may lead to poor response to treatment.

New findings explain how genetic changes, body clocks, and certain molecules affect tissue response to stress hormones.

The conclusion is that genetic changes in the glucocorticoid receptor can lead to conditions affecting stress response, immunity, and metabolism, requiring personalized treatment.

The review suggests thorough evaluation and genetic testing for proper diagnosis and treatment of Chrousos syndrome.

Mutations in the NR3C1 gene cause a rare condition that affects hormone signaling and can lead to various symptoms, with dexamethasone as a treatment option.

The R343H mutation in the VDR gene causes vitamin D-resistant rickets with alopecia by impairing specific gene activity.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Estrogen therapy can reduce skin aging but has cancer risks.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Androgen receptors are key for development and health, affecting conditions like prostate cancer and male pattern baldness.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

Mutations in certain receptors can cause diseases and offer new treatment options.

The androgen receptor is a promising target for breast cancer treatment, especially in triple-negative cases, but more research is needed for personalized therapies.

Targeting the actin cytoskeleton could improve skin healing and reduce scarring.

Mice with more Flightless I protein grew back their claws better after amputation.

Vitamin D receptor binds similarly to natural and synthetic ligands, affecting gene regulation.

Vitamin D is important for bones, hair, blood pressure, and breast development.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.

New treatments for male hypogonadism are effective and should be personalized.

Researchers found 15 new genetic links to skin traits in Japanese women.

Targeting glucocorticoid action might help treat type-2 diabetes, but human trials are needed.

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

Genes linked to wool fineness in sheep have been identified.

Msx and Dlx genes are crucial for development, controlling cell behaviors like growth and differentiation through their roles as gene regulators.

Different light affects cell functions and can help treat skin conditions.

Deleting MED1 in skin cells causes hair loss and skin changes.