Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study synthesizes knowledge of how dendritic cell signals, epithelial integrins, and fibroblast activity converge on TGF-β1 to maintain or disrupt skin healing, contrasting normal and fibrotic scar formation and suggesting possible integrin and immune-targeted treatments for skin fibrosis.

This review discusses the role of vitamin D receptor signaling in hair follicle biology for alopecia treatment and underscores the need for continued research, without presenting new clinical results.

This research suggests that the vitamin D receptor may regulate hair follicle cycling and provide genoprotection against skin carcinogenesis through a mechanism independent of 1,25-dihydroxyvitamin D3, based on evidence from mouse models.

This article compares two rare genetic diseases, vitamin D-dependent rickets type 1 and type 2, focusing on their similar presentations of hypocalcemia and rickets in infancy, but reports no new clinical results.

This review highlights the crucial role of vitamin D signaling in epidermal stem cells during skin wound healing, emphasizing its distinct functions from calcium metabolism and its importance in genomic regulation mediated by the vitamin D receptor.

This study observed that vitamin D receptor knockout mice exhibit impaired epidermal differentiation and progressive hair loss, suggesting the importance of the vitamin D receptor in normal skin and hair follicle development.

This review discusses the role of the unliganded vitamin D receptor in hair follicle cycling and tumor formation in mice and reports no new experimental findings.

This abstract reviews hereditary vitamin D-resistant rickets, a rare genetic condition causing severe early childhood rickets, and reports no new results; effective treatment typically requires high doses of calcium to address hypocalcemia and secondary hyperparathyroidism.

This review examines lesser-known factors contributing to polycystic ovarian syndrome and reports no new clinical results, emphasizing the need for further research into individualized treatment and prevention strategies.

This study showed that vitamin D receptor gene-deficient rats exhibit hair loss and skin abnormalities due to differences in gene and protein expression patterns, while ligand-independent VDR action is crucial for normal hair cycle maintenance and skin formation.

This study suggests that impaired VDR signaling in mice leads to dysregulated Ddit4 expression, impacting hair cycle progression and wound healing.

This study found that large excisional wounds in rats across seven strains do not regenerate new hair follicles, unlike in mice, possibly due to differences in epidermal competence and transcriptional profiles.

This study described the clinical and genetic features of two Iranian siblings with hereditary vitamin D resistant rickets, identifying a specific VDR gene mutation contributing to their symptoms.

Genetic research has advanced our understanding of skin diseases, but complex conditions require an integrative approach for deeper insight.

This study found that topical patidegib gel significantly shrank basal cell carcinomas in Gorlin syndrome patients without causing the systemic side effects common with oral hedgehog inhibitors.

This study observed that Egyptian patients with discoid lupus erythematosus have significantly lower serum vitamin D3 and antioxidant levels compared to healthy controls, suggesting potential benefits of vitamin D3 and antioxidant supplementation.

This study found that a specific mutation in the mouse RXRalpha gene significantly impacts immune responses and causes hair loss and skin cysts.

This study found that the deletion of soluble epoxide hydrolase (sEH) in mice altered the hair follicle cycle and increased hair growth through effects on hair follicle stem and matrix cells.

This review covers the structure, development, cycle, and molecular regulation of hair follicles but does not report new results, aiming to offer insights for addressing hair follicle-related diseases.

This review examines apoptotic and anti-apoptotic mechanisms in skin homeostasis and related diseases but presents no new research findings.

This study found that vitamin D regulates cholesterol metabolism and may influence prostate cancer development through mechanisms affecting prostate cell growth and sex hormone metabolism.

This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.

This article discusses the clinical presentation, histopathologic findings, and pathogenesis hypotheses of vitiligo without reporting new clinical results.

This review summarizes recent multidisciplinary advances in sebaceous gland research and highlights potential novel therapeutic strategies for skin diseases, but it reports no new clinical results.

This review explores the potential (neuro-)endocrine influences on hair follicle epithelial stem cell biology and emphasizes the need for more systematic research, but it provides no new empirical results.

This review discusses the role of the mineralocorticoid receptor in skin biology, highlighting its potential involvement in keratinocyte and hair physiology, and proposes it may affect the side effects of glucocorticoid use.

This review suggests that decreased serum 25-hydroxyvitamin D levels may play a role in different types of non-scarring alopecia, but further studies are needed to explore vitamin D supplementation as a therapeutic option.

This study suggests that controlling light exposure can influence cashmere growth by triggering hair follicles to enter their active growth phase sooner, potentially involving the CSDC2 gene as a key regulator.

In this study using data from young women in West Bengal, India, the researchers identified that leptin signaling impairment, insulin resistance, and specific gene mutations significantly contribute to PCOS, with obesity commonly manifesting in affected individuals.

This review suggests that the mTOR signaling pathway may play a significant role in hair follicle health by influencing the effects of Vitamin D receptor deficiency, potentially contributing to hair follicle damage and related hair loss conditions.